Search Results - "MORRELL, Craig"

Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity by Koupenova, Milka, Livada, Alison C., Morrell, Craig N.

“…Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has…”
Get full text

Emerging roles for platelets as immune and inflammatory cells by Morrell, Craig N., Aggrey, Angela A., Chapman, Lesley M., Modjeski, Kristina L.

“…Despite their small size and anucleate status, platelets have diverse roles in vascular biology. Not only are platelets the cellular mediator of thrombosis,…”
Get full text

Platelets: killers of parasites or patients? by Morrell, Craig N.

Get full text

The Platelet Napoleon Complex-Small Cells, but Big Immune Regulatory Functions by Morrell, Craig N, Pariser, Daphne N, Hilt, Zachary T, Vega Ocasio, Denisse

“…Platelets have dual physiologic roles as both cellular mediators of thrombosis and immune modulatory cells. Historically, the thrombotic function of platelets…”
Get full text

Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions by Yang, Moua, Cooley, Brian C., Li, Wei, Chen, Yiliang, Vasquez-Vivar, Jeannette, Scoggins, Na'il O., Cameron, Scott J., Morrell, Craig N., Silverstein, Roy L.

“…Atherothrombosis is a process mediated by dysregulated platelet activation that can cause life-threatening complications and is the leading cause of death by…”
Get full text

The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function by Bennett, J. Allen, Mastrangelo, Michael A., Ture, Sara K., Smith, Charles O., Loelius, Shannon G., Berg, Rachel A., Shi, Xu, Burke, Ryan M., Spinelli, Sherry L., Cameron, Scott J., Carey, Thomas E., Brookes, Paul S., Gerszten, Robert E., Sabater-Lleal, Maria, de Vries, Paul S., Huffman, Jennifer E., Smith, Nicholas L., Morrell, Craig N., Lowenstein, Charles J.

“…Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may…”
Get full text

Essential Amino Acids—Essential in Arterial Thrombosis by Hilt, Zachary T., Morrell, Craig N.

Get full text

Reactive Oxygen Species: Finding the Right Balance by Morrell, Craig N

Get full text

Platelets present antigen in the context of MHC class I by Chapman, Lesley M, Aggrey, Angela A, Field, David J, Srivastava, Kalyan, Ture, Sara, Yui, Katsuyuki, Topham, David J, Baldwin, 3rd, William M, Morrell, Craig N

“…Platelets are most recognized for their vital role as the cellular mediator of thrombosis, but platelets also have important immune functions. Platelets…”
Get full text

Lung megakaryocytes are immune modulatory cells by Pariser, Daphne N, Hilt, Zachary T, Ture, Sara K, Blick-Nitko, Sara K, Looney, Mark R, Cleary, Simon J, Roman-Pagan, Estheany, Saunders, 2nd, Jerry, Georas, Steve N, Veazey, Janelle, Madere, Ferralita, Santos, Laura Tesoro, Arne, Allison, Huynh, Nguyen Pt, Livada, Alison C, Guerrero-Martin, Selena M, Lyons, Claire, Metcalf-Pate, Kelly A, McGrath, Kathleen E, Palis, James, Morrell, Craig N

“…Although platelets are the cellular mediators of thrombosis, they are also immune cells. Platelets interact both directly and indirectly with immune cells,…”
Get full text

Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice by Maurya, Preeti, Ture, Sara K., Li, Chen, Scheible, Kristin M., McGrath, Kathleen E., Palis, James, Morrell, Craig N.

“…Thrombocytopenia is common in preterm neonates. Platelet transfusions are sometimes given to thrombocytopenic neonates with the hope of reducing the bleeding…”
Get full text

Platelet MHC class I mediates CD8+ T-cell suppression during sepsis by Guo, Li, Shen, Sikui, Rowley, Jesse W., Tolley, Neal D., Jia, Wenwen, Manne, Bhanu Kanth, McComas, Kyra N., Bolingbroke, Ben, Kosaka, Yasuhiro, Krauel, Krystin, Denorme, Frederik, Jacob, Shancy P., Eustes, Alicia S., Campbell, Robert A., Middleton, Elizabeth A., He, Xiao, Brown, Samuel M., Morrell, Craig N., Weyrich, Andrew S., Rondina, Matthew T.

“…Circulating platelets interact with leukocytes to modulate host immune and thrombotic responses. In sepsis, platelet-leukocyte interactions are increased and…”
Get full text

PAD4 and von Willebrand Factor Link Inflammation and Thrombosis by Morrell, Craig N, Hilt, Zachary T, Pariser, Daphne N, Maurya, Preeti

Get full text

Compound heterozygous RYR1‐RM mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival by Liang, Chen, Malik, Sundeep, He, Miao, Groom, Linda, Ture, Sara K., O'Connor, Thomas N., Morrell, Craig N., Dirksen, Robert T.

“…Pathogenic variants in the type I ryanodine receptor (RYR1) result in a wide range of muscle disorders referred to as RYR1‐related myopathies (RYR1‐RM). We…”
Get full text

Understanding platelets in malaria infection by Morrell, Craig N

“…PURPOSE OF REVIEWPlatelets are most identified as the cellular mediator of thrombosis. It is becoming increasingly evident that platelets also have complicated…”
Get full text

Estrogen activates endothelial exocytosis by Kim, Christine S., Yea, Kyungmoo, Morrell, Craig N., Jeong, Youngtae, Lowenstein, Charles J.

“…Estrogen therapy is used to treat patients with post-menopausal symptoms, such as hot flashes and dyspareunia. Estrogen therapy also decreases the risk of…”
Get full text

Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype by Cameron, Scott J, Mix, Doran S, Ture, Sara K, Schmidt, Rachel A, Mohan, Amy, Pariser, Daphne, Stoner, Michael C, Shah, Punit, Chen, Lijun, Zhang, Hui, Field, David J, Modjeski, Kristina L, Toth, Sandra, Morrell, Craig N

“…OBJECTIVE—Reduced blood flow and tissue oxygen tension conditions result from thrombotic and vascular diseases such as myocardial infarction, stroke, and…”
Get full text

Platelets as initiators and mediators of inflammation at the vessel wall by Shi, Guanfang, Morrell, Craig N

“…Abstract Platelets are dynamic cells with activities that extend beyond thrombosis including an important role in initiating and sustaining vascular…”
Get full text

Markers of platelet activation foR identification of late onset sEpsis in infaNTs: PARENT study protocol by O’Reilly, Daniel, Murphy, Claire Anne, Moore, Carmel Maria, Ní Áinle, Fionnuala, Gormley, Isobel Claire, Morrell, Craig N., Curley, Anna, Mc Callion, Naomi, Maguire, Patricia

“…Background Newborns are at high risk of sepsis. At present there is no definitive “rule in” blood test for sepsis at the point of clinical concern. A positive…”
Get full text

Commentary on "Desialylated Platelets Maintain Immune Quiescence through Regulating Kupffer Cells" by Li, Chen, Morrell, Craig N

Get full text