Search Results - "MORIWAKI, Hiroki"

Fluorine-containing drugs approved by the FDA in 2019 by Mei, Haibo, Remete, Attila Márió, Zou, Yupiao, Moriwaki, Hiroki, Fustero, Santos, Kiss, Lorand, Soloshonok, Vadim A., Han, Jianlin

“…Eleven new fluorine-containing FDA-approved pharmaceuticals are discussed. Therapeutic areas of these newly developed fluorinated pharmaceuticals include…”
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Next generation organofluorine containing blockbuster drugs by Han, Jianlin, Remete, Attila Márió, Dobson, Luca S., Kiss, Lorand, Izawa, Kunisuke, Moriwaki, Hiroki, Soloshonok, Vadim A., O’Hagan, David

“…[Display omitted] •Selected organofluorine-containing blockbuster drugs were profiled.•General aspects of the biological properties of these compounds were…”
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Muscle-Protective Effect of Carnosine against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotube by RAHMAN, Md Mizanur, ULLA, Anayt, MORIWAKI, Hiroki, YASUKAWA, Yusuke, UCHIDA, Takayuki, NIKAWA, Takeshi

“…This study investigated the protective effect of carnosine and its components (L-histidine and β-alanine [HA]) against dexamethasone (Dex)-induced muscle…”
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Asymmetric Synthesis of Tailor-Made Amino Acids Using Chiral Ni(II) Complexes of Schiff Bases. An Update of the Recent Literature by Zou, Yupiao, Han, Jianlin, Saghyan, Ashot S, Mkrtchyan, Anna F, Konno, Hiroyuki, Moriwaki, Hiroki, Izawa, Kunisuke, Soloshonok, Vadim A

“…Tailor-made amino acids are indispensable structural components of modern medicinal chemistry and drug design. Consequently, stereo-controlled preparation of…”
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Temporal variations in the linkages between plants and flower visitors and the pollination success of Primula modesta along the snowmelt gradient by Moriwaki, Hiroki, Takyu, Masaaki, Kameyama, Yoshiaki

“…Although pollination networks between plants and flower visitors are diverse and flexible, seed production of many plant species is restricted by pollen…”
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Kitamura Electrophilic Fluorination Using HF as a Source of Fluorine by Han, Jianlin, Butler, Greg, Moriwaki, Hiroki, Konno, Hiroyuki, Soloshonok, Vadim A, Kitamura, Tsugio

“…This review article focused on the innovative procedure for electrophilic fluorination using HF and in situ generation of the required electrophilic species…”
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Large‐Scale Asymmetric Synthesis of Fmoc‐(S)‐2‐Amino‐6,6,6‐Trifluorohexanoic Acid by Yin, Zizhen, Moriwaki, Hiroki, Abe, Hidenori, Miwa, Toshio, Han, Jianlin, Soloshonok, Vadim A.

“…Here we report the first large‐scale synthesis of Fmoc‐(S)‐2‐amino‐6,6,6‐trifluorohexanoic acid via asymmetric alkylation of chiral Ni(II)‐complex of glycine…”
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Asymmetric synthesis of (2S,3S)-3-Me-glutamine and (R)-allo-threonine derivatives proper for solid-phase peptide coupling by Tokairin, Yoshinori, Soloshonok, Vadim A., Moriwaki, Hiroki, Konno, Hiroyuki

“…Practical new routes for preparation of (2 S ,3 S )-3-Me-glutamine and ( R )- allo -threonine derivatives, the key structural components of cytotoxic marine…”
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Optical Resolution of Rimantadine by Han, Jianlin, Takeda, Ryosuke, Sato, Tatsunori, Moriwaki, Hiroki, Abe, Hidenori, Izawa, Kunisuke, Soloshonok, Vadim A

“…This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure ( )-rimantadine…”
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Asymmetric Mannich reactions of ( S )- N - tert -butylsulfinyl-3,3,3-trifluoroacetaldimines with yne nucleophiles by Li, Ziyi, Wang, Li, Huang, Yunqi, Mei, Haibo, Konno, Hiroyuki, Moriwaki, Hiroki, Soloshonok, Vadim A, Han, Jianlin

“…In the present work, arylethynes were studied as new C-nucleophiles in the asymmetric Mannich addition reactions with ( )- -…”
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Convenient Asymmetric Synthesis of Fmoc-(S)-6,6,6-Trifluoro-Norleucine by Mei, Haibo, Yin, Zizhen, Miwa, Toshio, Moriwaki, Hiroki, Abe, Hidenori, Han, Jianlin, Soloshonok, Vadim A

“…In this work we report a convenient asymmetric synthesis of Fmoc-(S)-6,6,6-trifluoro-norleucine via alkylation reaction of chiral glycine equivalent. The…”
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Development of Hamari Ligands for Practical Asymmetric Synthesis of Tailor-Made Amino Acids by Han, Jianlin, Romoff, Todd T, Moriwaki, Hiroki, Konno, Hiroyuki, Soloshonok, Vadim A

“…Enantiomerically pure tailor-made amino acids are in extremely high demand in nearly every sector of the health-related industries. In particular, the rapidly…”
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Practical Method for Preparation of (S)‑2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution by Mei, Haibo, Han, Jianlin, Takeda, Ryosuke, Sakamoto, Tsubasa, Miwa, Toshio, Minamitsuji, Yutaka, Moriwaki, Hiroki, Abe, Hidenori, Soloshonok, Vadim A

“…This work reports an operationally convenient ∼20 g scale synthesis of (S)-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic…”
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Asymmetric Synthesis of 4,4‐(Difluoro)glutamic Acid via Chiral Ni(II)‐Complexes of Dehydroalanine Schiff Bases. Effect of the Chiral Ligands Structure on the Stereochemical Outcome by Tokairin, Yoshinori, Shigeno, Yuhei, Han, Jianlin, Röschenthaler, Gerd‐Volker, Konno, Hiroyuki, Moriwaki, Hiroki, Soloshonok, Vadim A.

“…Four differently substituted chiral Ni(II)‐complexes of dehydroalanine Schiff base were prepared and reacted with BrCF2COOEt/Cu under the standard reaction…”
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Tandem Alkylation–Second-Order Asymmetric Transformation Protocol for the Preparation of Phenylalanine-Type Tailor-Made α‑Amino Acids by Takeda, Ryosuke, Kawashima, Aki, Yamamoto, Junya, Sato, Tatsunori, Moriwaki, Hiroki, Izawa, Kunisuke, Abe, Hidenori, Soloshonok, Vadim A

“…In this work, we disclose an advanced general process for the synthesis of tailor-made α-amino acids (α-AAs) via tandem alkylation–second-order asymmetric…”
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Inexpensive chemical method for preparation of enantiomerically pure phenylalanine by Moriwaki, Hiroki, Resch, Daniel, Li, Hengguang, Ojima, Iwao, Takeda, Ryosuke, Aceña, José Luis, Soloshonok, Vadim

“…Here, we report the most inexpensive procedure for chemical synthesis of enantiomerically pure phenylalanine. As a source of chirality, we use the ultimately…”
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Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with (R)-2-(N-{2-[N-alkyl-N-(1-phenylethyl)amino]acetyl}amino)benzophenone; a case of configurationally stable stereogenic nitrogen by Moriwaki, Hiroki, Resch, Daniel, Li, Hengguang, Ojima, Iwao, Takeda, Ryosuke, Aceña, José Luis, Soloshonok, Vadim A

“…A family of chiral ligands derived from α-phenylethylamine and 2-aminobenzophenone were prepared by alkylation of the nitrogen atom. Upon reaction with glycine…”
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Chemical Aspects of Human and Environmental Overload with Fluorine by Han, Jianlin, Kiss, Loránd, Mei, Haibo, Remete, Attila Márió, Ponikvar-Svet, Maja, Sedgwick, Daniel Mark, Roman, Raquel, Fustero, Santos, Moriwaki, Hiroki, Soloshonok, Vadim A

“…Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing compounds in modern technology and daily life, the explosive…”
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Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes by Wang, Yibing, Song, Xiaohan, Wang, Jiang, Moriwaki, Hiroki, Soloshonok, Vadim A., Liu, Hong

“…This review article critically discusses examples of asymmetric synthesis of tailor-made α-amino acids via homologation of Ni(II) complexes of glycine and…”
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Eclipta thermalis, a previously common weed, threatened by the expansion of the exotic congener E. alba in Japanese rice paddies by Kameyama, Yoshiaki, Moriwaki, Hiroki, Suzuki, Yuto, Fujiyoshi, Masaaki

“…Rice paddies are wetland ecosystems recognized as important habitats for many organisms; however, the hybridization‐related extinction risk of native plant…”
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