Search Results - "MORITA, Masahiro"

mTOR coordinates protein synthesis, mitochondrial activity and proliferation by Morita, Masahiro, Gravel, Simon-Pierre, Hulea, Laura, Larsson, Ola, Pollak, Michael, St-Pierre, Julie, Topisirovic, Ivan

“…Protein synthesis is one of the most energy consuming processes in the cell. The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase…”
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mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1 by Morita, Masahiro, Prudent, Julien, Basu, Kaustuv, Goyon, Vanessa, Katsumura, Sakie, Hulea, Laura, Pearl, Dana, Siddiqui, Nadeem, Strack, Stefan, McGuirk, Shawn, St-Pierre, Julie, Larsson, Ola, Topisirovic, Ivan, Vali, Hojatollah, McBride, Heidi M., Bergeron, John J., Sonenberg, Nahum

“…The mechanisms that link environmental and intracellular stimuli to mitochondrial functions, including fission/fusion, ATP production, metabolite biogenesis,…”
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Amorphous cellulose nanofiber supercapacitors by Fukuhara, Mikio, Kuroda, Tomoyuki, Hasegawa, Fumihiko, Hashida, Toshiyuki, Takeda, Mitsuhiro, Fujima, Nobuhisa, Morita, Masahiro, Nakatani, Takeshi

“…Despite the intense interest in cellulose nanofibers (CNFs) for biomedical and engineering applications, no research findings about the electrical energy…”
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The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression by Ito-Kureha, Taku, Miyao, Takahisa, Nishijima, Saori, Suzuki, Toru, Koizumi, Shin-ichi, Villar-Briones, Alejandro, Takahashi, Akinori, Akiyama, Nobuko, Morita, Masahiro, Naguro, Isao, Ishikawa, Hiroki, Ichijo, Hidenori, Akiyama, Taishin, Yamamoto, Tadashi

“…A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this thymic positive selection are…”
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Localized surface plasmon resonance-mediated fluorescence signals in plasmonic nanoparticle-quantum dot hybrids for ultrasensitive Zika virus RNA detection via hairpin hybridization assays by Adegoke, Oluwasesan, Morita, Masahiro, Kato, Tatsuya, Ito, Masahito, Suzuki, Tetsuro, Park, Enoch Y.

“…The current epidemic caused by the Zika virus (ZIKV) and the devastating effects of this virus on fetal development, which result in an increased incidence of…”
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mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation by Morita, Masahiro, Gravel, Simon-Pierre, Chénard, Valérie, Sikström, Kristina, Zheng, Liang, Alain, Tommy, Gandin, Valentina, Avizonis, Daina, Arguello, Meztli, Zakaria, Chadi, McLaughlan, Shannon, Nouet, Yann, Pause, Arnim, Pollak, Michael, Gottlieb, Eyal, Larsson, Ola, St-Pierre, Julie, Topisirovic, Ivan, Sonenberg, Nahum

“…mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases…”
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High-energy density cellulose nanofibre supercapacitors enabled by pseudo-solid water molecules by Fukuhara, Mikio, Yokotsuka, Tomonori, Morita, Masahiro, Ito, Tatsunori, Yada, Minoru, Nakatani, Takeshi, Hashida, Toshiyuki

“…Compared with conventional electrochemical supercapacitors and lithium-ion batteries, the novel amorphous cellulose nanofibre (ACF) supercapacitor demonstrates…”
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Amorphous cellulose nanofiber supercapacitors with voltage-charging performance by Fukuhara, Mikio, Yokotsuka, Tomonori, Hashida, Toshiyuki, Miwa, Tamon, Fujima, Nobuhisa, Morita, Masahiro, Nakatani, Takeshi, Nonomura, Fuminari

“…The electric charge storage properties of amorphous cellulose nanofiber (ACF) supercapacitors with different metal carboxylate radicals (COOM; M: Na(I),…”
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Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1 by Rouya, Christopher, Siddiqui, Nadeem, Morita, Masahiro, Duchaine, Thomas F, Fabian, Marc R, Sonenberg, Nahum

“…MicroRNAs (miRNAs) play critical roles in a variety of biological processes through widespread effects on protein synthesis. Upon association with the…”
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La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1) by Fonseca, Bruno D., Zakaria, Chadi, Jia, Jian-Jun, Graber, Tyson E., Svitkin, Yuri, Tahmasebi, Soroush, Healy, Danielle, Hoang, Huy-Dung, Jensen, Jacob M., Diao, Ilo T., Lussier, Alexandre, Dajadian, Christopher, Padmanabhan, Niranjan, Wang, Walter, Matta-Camacho, Edna, Hearnden, Jaclyn, Smith, Ewan M., Tsukumo, Yoshinori, Yanagiya, Akiko, Morita, Masahiro, Petroulakis, Emmanuel, González, Jose L., Hernández, Greco, Alain, Tommy, Damgaard, Christian K.

“…The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of protein synthesis. The best studied targets of mTORC1 in translation are the…”
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Fabrication of optically transparent cotton fiber composite by Abe, Kentaro, Morita, Masahiro, Yano, Hiroyuki

“…In this study, we fabricated optically transparent cotton fibers composite by resin impregnation without having to prepare cellulose nanofibers. Although the…”
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High-energy storage capacity of cellulose nanofiber supercapacitors using bound water by Fukuhara, Mikio, Yokotsuka, Tomonori, Takashina, Takuya, Fujima, Nobuhisa, Morita, Masahiro, Ito, Tatsunori, Nakatani, Takeshi, Hashida, Toshiyuki

“…The performance of electric double-layer capacitors and lithium-ion batteries deteriorates with increasing humidity. The desirable effect of bound water on the…”
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Age‐dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution by Adjei‐Mosi, Jennifer, Sun, Qing, Smithson, Steven Blake, Shealy, Gavyn Lee, Amerineni, Krupa Dhruvitha, Liang, Zerong, Chen, Hanqing, Wang, Mei, Ping, Qinggong, Han, Jingyan, Morita, Masahiro, Kamat, Amrita, Musi, Nicolas, Zang, Mengwei

“…Our studies indicate that the longevity factor SIRT1 is implicated in metabolic disease; however, whether and how hepatocyte‐specific SIRT1 signaling is…”
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Clinicopathological analysis of hepatic immune-related adverse events in comparison with autoimmune hepatitis and graft-versus host disease by Hagiwara, Satoru, Watanabe, Tomohiro, Kudo, Masatoshi, Minaga, Kosuke, Komeda, Yoriaki, Kamata, Ken, Kimura, Masatomo, Hayashi, Hidetoshi, Nakagawa, Kazuhiko, Ueshima, Kazuomi, Minami, Yasunori, Aoki, Tomoko, Takita, Masahiro, Morita, Masahiro, Cishina, Hirokazu, Ida, Hiroshi, Park, Ah-Mee, Nishida, Naoshi

“…Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) are widely used to treat advanced…”
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Role of phlebotomy in the treatment of liver damage related to erythropoietic porphyria by Hagiwara, Satoru, Nishida, Naoshi, Ida, Hiroshi, Ueshima, Kazuomi, Minami, Yasunori, Takita, Masahiro, Aoki, Tomoko, Morita, Masahiro, Chishina, Hirokazu, Komeda, Yoriaki, Yoshida, Akihiro, Park, Ah-Mee, Sato, Masako, Kawada, Akira, Nakano, Hajime, Nakagawa, Hiroshi, Kudo, Masatoshi

“…Liver damage affects the prognosis of patients with erythropoietic protoporphyria (EPP). However, there is no radical cure for EPP patients with severe liver…”
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Distinct perturbation of the translatome by the antidiabetic drug metformin by Larsson, Ola, Morita, Masahiro, Topisirovic, Ivan, Alain, Tommy, Blouin, Marie-Jose, Pollak, Michael, Sonenberg, Nahum

“…Metformin has been reported to lower cancer incidence among type Il diabetics. Metformin exhibits antiproliferative and antineoplastic effects associated with…”
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Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis by Li, Guannan, Chen, Hanqing, Shen, Feng, Smithson, Steven Blake, Shealy, Gavyn Lee, Ping, Qinggong, Liang, Zerong, Han, Jingyan, Adams, Andrew C, Li, Yu, Feng, Dechun, Gao, Bin, Morita, Masahiro, Han, Xianlin, Huang, Tim H, Musi, Nicolas, Zang, Mengwei

“…Lipid accumulation induced by alcohol consumption is not only an early pathophysiological response but also a prerequisite for the progression of…”
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eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies by Alain, Tommy, Morita, Masahiro, Fonseca, Bruno D, Yanagiya, Akiko, Siddiqui, Nadeem, Bhat, Mamatha, Zammit, Domenick, Marcus, Victoria, Metrakos, Peter, Voyer, Lucie-Anne, Gandin, Valentina, Liu, Yi, Topisirovic, Ivan, Sonenberg, Nahum

“…Active-site mTOR inhibitors (asTORi) hold great promise for targeting dysregulated mTOR signaling in cancer. Because of the multifaceted nature of mTORC1…”
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Clinical implication of immune checkpoint inhibitor on the chronic hepatitis B virus infection by Hagiwara, Satoru, Nishida, Naoshi, Ida, Hiroshi, Ueshima, Kazuomi, Minami, Yasunori, Takita, Masahiro, Aoki, Tomoko, Morita, Masahiro, Chishina, Hirokazu, Komeda, Yoriaki, Yoshida, Akihiro, Hayashi, Hidetoshi, Nakagawa, Kazuhiko, Kudo, Masatoshi

“…Aim The risk of hepatitis B virus (HBV) reactivation with immune checkpoint inhibitors (ICIs) is an important issue that has not yet been fully investigated…”
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Diagnostic criteria for Patulous Eustachian Tube: A proposal by the Japan Otological Society by Kobayashi, Toshimitsu, Morita, Masahiro, Yoshioka, Satoshi, Mizuta, Kunihiro, Ohta, Shigeto, Kikuchi, Toshiaki, Hayashi, Tatsuya, Kaneko, Akihiro, Yamaguchi, Nobumasa, Hashimoto, Sho, Kojima, Hiromi, Murakami, Shingo, Takahashi, Haruo

“…Patulous Eustachian Tube (PET) is of increasing importance in otology. However, despite the abundance of diseases requiring a differential diagnosis from PET,…”
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