Search Results - "MORGANROTH, J"

Cardiac Repolarization and the Safety of New Drugs Defined by Electrocardiography by Morganroth, J

“…A compelling assessment of both short‐ and long‐term cardiac safety is increasingly emphasized before regulatory marketing approval. In that context, cardiac…”
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Response to "Design of the 'Thorough QT Study'" by Morganroth, J

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Evaluation and Management of Cardiac Safety Using the Electrocardiogram in Oncology Clinical Trials: Focus on Cardiac Repolarization (QTc Interval) by Morganroth, J, Shah, R R, Scott, J W

“…Non‐antiarrhythmic drugs have been reported to prolong the QTc interval and induce potentially fatal ventricular tachyarrhythmias. An increasing number of…”
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Effects of the Selective α -Adrenoceptor Antagonist Silodosin on ECGs of Healthy Men in a Randomized, Double-Blind, Placebo- and Moxifloxacin-Controlled Study

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A Thorough Electrocardiogram Study of Edoxaban, a Novel Factor Xa Inhibitor by Mendell, J., Basavapathruni, R., Swearingen, D., Draves, A., Zhang, G., Morganroth, J.

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Consensus group on new-generation antihistamines (CONGA): present status and recommendations by Holgate, S. T., Canonica, G. W., Simons, F. E. R., Taglialatela, M., Tharp, M., Timmerman, H., Yanai, K.

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Overview of electrocardiographic and cardiovascular safety data for sparfloxacin by Jaillon, P., Morganroth, J., Brumpt, I., Talbot, G.

“…During the preclinical development of sparfloxacin, prolongation of the electrocardiographic QT interval was observed in dogs. Subsequently, the effect of…”
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Relations of QTc prolongation on the electrocardiogram to torsades de pointes : definitions and mechanisms by MORGANROTH, J

“…Antiarrhythmic drug-induced ventricular tachyarrhythmias have traditionally been identified on the basis of prolongation of the QT interval and the appearance…”
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Electrocardiographic Identification of Drug-Induced QT Prolongation: Assessment by Different Recording and Measurement Methods by Sarapa, Nenad, Morganroth, Joel, Couderc, Jean-Philippe, Francom, Steven F., Darpo, Borje, Fleishaker, Joseph C., McEnroe, Janet D., Chen, William T., Zareba, Wojciech, Moss, Arthur J.

“…Background: Careful assessment of QT interval prolongation is required before novel drugs are approved by regulatory authorities. The choice of the most…”
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Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval by Gillen, Michael S., Miller, Barry, Chaikin, Philip, Morganroth, Joel

“…Aims  The objective of this study was to compare the effects of high doses of ebastine with terfenadine and placebo on QTc. Methods  Thirty‐two subjects were…”
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Quinidine-Related Mortality in the Short-to-Medium-Term Treatment of Ventricular Arrhythmias: A Meta-Analysis by Morganroth, Joel, Goin, James E

“…BACKGROUNDThe interim results of the Cardiac Arrhythmia Suppression Trial requires physicians to use a higher threshold for employing antiarrhythmic agents in…”
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A review of the cardiac systemic side-effects of antihistamines: ebastine by Moss, A. J., Chaikin, P., Garcia, J. D., Gillen, M., Roberts, D. J., Morganroth, J.

“…The cardiac safety of ebastine, a long‐acting, non‐sedating antihistamine, has been thoroughly assessed in phase I–III clinical studies. Ebastine alone at the…”
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1156 POSTER High dose palonosetron does not alter ECG parameters including QTc interval in healthy subjects: results of a dose-response, double blind, randomized, parallel E14 study of palonosetron vs. moxifloxacin or placebo by Morganroth, J, Parisi, S, Moresino, C, Thorn, M, Cullen, M.T

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Evaluation of the effect on cardiac repolarization (QTc interval) of oncologic drugs by Morganroth, J

“…The 12-lead electrocardiograph (ECG) is the standard safety measurement used in clinical trials to identify drug-induced cardiac adverse effects. Drug-induced…”
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Mechanisms and risk factors for proarrhythmia with type Ia compared with Ic antiarrhythmic drug therapy by Levine, J H, Morganroth, J, Kadish, A H

“…Proarrhythmia defined as the exacerbation of existing arrhythmias or the genesis of new arrhythmias de novo may result from any antiarrhythmic agent. The two…”
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Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: Distinguishing a drug effect from spontaneous variability by Pratt, Craig M., Ruberg, Stephen, Morganroth, Joel, McNutt, Bruce, Woodward, James, Harris, Stuart, Ruskin, Jeremy, Moyé, Lemuel

“…The primary goal of this investigation was to describe the effect of terfenadine on the QT interval corrected for heart rate (QTc) of the scalar…”
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A definitive or thorough phase 1 QT ECG trial as a requirement for drug safety assessment by Morganroth, Joel

“…Prolongation of the QT interval by noncardiac drugs is the commonest cause of drug delays in development, nonapprovals and withdrawal from after marketing. The…”
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Spontaneous variability of complex ventricular arrhythmias detected by long-term electrocardiographic recording by Michelson, E L, Morganroth, J

“…Variations in the frequency of complex ventricular arrhythmias were evaluated by consecutive 24-hour long-term electrocardiographic recordings over 4 days…”
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Limitations of routine long-term electrocardiographic monitoring to assess ventricular ectopic frequency by Morganroth, J, Michelson, E L, Horowitz, L N, Josephson, M E, Pearlman, A S, Dunkman, W B

“…Variations in the frequency of ventricular premature depolarizations (VPDs) were evaluated with three consecutive 24-hour long-term electrocardiography monitor…”
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Effect of propranolol on ventricular arrhythmia. The beta-blocker heart attack trial experience by Lichstein, E, Morganroth, J, Harrist, R, Hubble, E

“…The Beta-Blocker Heart Attack Trial (BHAT) was a multicenter, randomized, double-blind, placebo-controlled trial that tested the effectiveness of propranolol…”
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