Search Results - "MORARI, Joseane"
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1
Glutamic acid promotes hair growth in mice
Published in Scientific reports (29-07-2021)“…Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in peripheral tissues. Abnormal distribution of glutamic acid receptors…”
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2
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity
Published in PloS one (18-01-2012)“…In experimental models, hypothalamic inflammation is an early and determining factor in the installation and progression of obesity. Pharmacological and…”
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3
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
Published in The Journal of neuroscience (14-01-2009)“…In animal models of diet-induced obesity, the activation of an inflammatory response in the hypothalamus produces molecular and functional resistance to the…”
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4
An older diabetes-induced mice model for studying skin wound healing
Published in PloS one (17-02-2023)“…Advances in wound treatment depend on the availability of animal models that reflect key aspects of human wound healing physiology. To this date, the accepted…”
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5
Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis
Published in Journal of neuroinflammation (31-08-2021)“…Interleukin-6 (IL6) produced in the context of exercise acts in the hypothalamus reducing obesity-associated inflammation and restoring the control of food…”
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6
Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity
Published in Diabetes (New York, N.Y.) (01-11-2014)“…Hypothalamic inflammation is a common feature of experimental obesity. Dietary fats are important triggers of this process, inducing the activation of…”
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7
High-Fat Diet Induces Apoptosis of Hypothalamic Neurons
Published in PloS one (02-04-2009)“…Consumption of dietary fats is amongst the most important environmental factors leading to obesity. In rodents, the consumption of fat-rich diets blunts leptin…”
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8
Endoplasmic Reticulum Stress in Colonic Mucosa of Ulcerative Colitis Patients Is Mediated by PERK and IRE1 Pathway Activation
Published in Mediators of inflammation (09-02-2022)“…Ulcerative colitis (UC) is characterized by a chronic overproduction of proinflammatory cytokines. During an acute phase, the endoplasmic reticulum (ER) is…”
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9
Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review
Published in BioMed research international (2019)“…Interleukin-6 (IL-6) is a unique cytokine that can play both pro- and anti-inflammatory roles depending on the anatomical site and conditions under which it…”
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10
Pregnancy Protects against Abnormal Gut Permeability Promoted via the Consumption of a High-Fat Diet in Mice
Published in Nutrients (01-12-2023)“…The consumption of large amounts of dietary fats and pregnancy are independent factors that can promote changes in gut permeability and the gut microbiome…”
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11
Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface-the protective role for BDNF
Published in Journal of neuroinflammation (09-01-2018)“…The consumption of large amounts of dietary fats activates an inflammatory response in the hypothalamus, damaging key neurons involved in the regulation of…”
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12
Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity
Published in Scientific reports (04-07-2016)“…Obesity is the result of a long-term positive energy balance in which caloric intake overrides energy expenditure. This anabolic state results from the…”
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13
n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus
Published in Diabetes (New York, N.Y.) (01-03-2016)“…Apoptosis of hypothalamic neurons is believed to play an important role in the development and perpetuation of obesity. Similar to the hippocampus, the…”
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14
Protein C Pretreatment Protects Endothelial Cells from SARS-CoV-2-Induced Activation
Published in Viruses (01-07-2024)“…SARS-CoV-2 can induce vascular dysfunction and thrombotic events in patients with severe COVID-19; however, the cellular and molecular mechanisms behind these…”
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15
TLR4 Expression in Bone Marrow-Derived Cells Is Both Necessary and Sufficient to Produce the Insulin Resistance Phenotype in Diet-Induced Obesity
Published in Endocrinology (Philadelphia) (01-01-2015)“…The anomalous activation of toll-like receptor 4 (TLR4) by dietary fats is one of the most important mechanisms linking obesity to insulin resistance. TLR4 is…”
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16
Topical essential fatty acid oil on wounds: Local and systemic effects
Published in PloS one (04-01-2019)“…The use of medicinal plants and their derivatives is increasing, and approximately one-third of all traditional herbal medicines are intended for wound…”
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17
Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus)
Published in PloS one (13-12-2017)“…Wounds are a common health problem. Coffee is widely consumed and its oil contains essential fatty acids. We evaluated the local (skin) and systemic effects…”
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18
Hypothalamic S1P/S1PR1 axis controls energy homeostasis
Published in Nature communications (25-09-2014)“…Sphingosine 1-phosphate receptor 1 (S1PR1) is a G-protein-coupled receptor for sphingosine-1-phosphate (S1P) that has a role in many physiological and…”
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19
Novel Role of CETP in Macrophages: Reduction of Mitochondrial Oxidants Production and Modulation of Cell Immune-Metabolic Profile
Published in Antioxidants (31-08-2022)“…Plasma cholesteryl ester transfer protein (CETP) activity diminishes HDL-cholesterol levels and thus may increase atherosclerosis risk. Experimental evidence…”
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20
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver
Published in Journal of hepatology (01-04-2008)“…Background/Aims The anti-inflammatory cytokine, interleukin-10 (IL-10), is known to exert a protective role in hepatic damage caused by viruses, alcohol,…”
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