Search Results - "MOR, Marco"

N‑Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition by Piomelli, Daniele, Scalvini, Laura, Fotio, Yannick, Lodola, Alessio, Spadoni, Gilberto, Tarzia, Giorgio, Mor, Marco

“…N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase primarily found in the endosomal–lysosomal compartment of innate and adaptive immune…”
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The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment by Santucci, Matteo, Vignudelli, Tatiana, Ferrari, Stefania, Mor, Marco, Scalvini, Laura, Bolognesi, Maria Laura, Uliassi, Elisa, Costi, Maria Paola

“…The Hippo pathway is an important organ size control signaling network and the major regulatory mechanism of cell-contact inhibition. Yes associated protein…”
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L718Q Mutation as New Mechanism of Acquired Resistance to AZD9291 in EGFR-Mutated NSCLC by Bersanelli, Melissa, Minari, Roberta, Bordi, Paola, Gnetti, Letizia, Bozzetti, Cecilia, Squadrilli, Anna, Lagrasta, Costanza Anna Maria, Bottarelli, Lorena, Osipova, Ganna, Capelletto, Enrica, Mor, Marco, Tiseo, Marcello

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Dysphagia and mechanical ventilation in SARS-COV-2 pneumonia: It's real by Bordejé Laguna, Luisa, Marcos-Neira, Pilar, de Lagrán Zurbano, Itziar Martínez, Marco, Esther Mor, Guisasola, Carlos Pollán, Viñas Soria, Constanza Dolores, Martí, Pilar Ricart

“…Dysphagia can be a consequence of prolonged hospitalization in intensive care units (ICUs) due to severe SARS-CoV-2 pneumonia. This study aims at Identifying…”
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Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy by Ronca, Roberto, Giacomini, Arianna, Di Salle, Emanuela, Coltrini, Daniela, Pagano, Katiuscia, Ragona, Laura, Matarazzo, Sara, Rezzola, Sara, Maiolo, Daniele, Torella, Rubben, Moroni, Elisabetta, Mazzieri, Roberta, Escobar, Giulia, Mor, Marco, Colombo, Giorgio, Presta, Marco

“…The fibroblast growth factor (FGF)/FGF receptor (FGFR) system plays a crucial role in cancer by affecting tumor growth, angiogenesis, drug resistance, and…”
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Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase by Pala, Daniele, Rivara, Silvia, Mor, Marco, Milazzo, Ferdinando Maria, Roscilli, Giuseppe, Pavoni, Emiliano, Giannini, Giuseppe

“…Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes. A dysregulated heparanase…”
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Low molecular weight heparins in COVID-19 patients: beware of augmented renal clearance by Tomasa-Irriguible, Teresa Maria, Martínez-Vega, Sergi, Mor-Marco, Ester, Herraiz-Ruiz, Alba, Raguer-Pardo, Laura, Cubells-Larrosa, Carlos

“…Histologic analysis of pulmonary vessels in patients with COVID-19 has shown widespread thrombosis with alveolar capillary microthrombi [1]. A 52-year-old man…”
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Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation by Solorzano, Carlos, Zhu, Chenggang, Battista, Natalia, Astarita, Giuseppe, Lodola, Alessio, Rivara, Silvia, Mor, Marco, Russo, Roberto, Maccarrone, Mauro, Antonietti, Francesca, Duranti, Andrea, Tontini, Andrea, Cuzzocrea, Salvatore, Tarzia, Giorgio, Piomelli, Daniele

“…Identifying points of control in inflammation is essential to discovering safe and effective antiinflammatory medicines. Palmitoylethanolamide (PEA) is a…”
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NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice by Fotio, Yannick, Mabou Tagne, Alex, Squire, Erica, Lee, Hye-lim, Phillips, Connor M., Chang, Kayla, Ahmed, Faizy, Greenberg, Andrew S., Villalta, S. Armando, Scarfone, Vanessa M., Spadoni, Gilberto, Mor, Marco, Piomelli, Daniele

“…Circulating monocytes participate in pain chronification but the molecular events that cause their deployment are unclear. Using a mouse model of hyperalgesic…”
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Discovery of novel FGF trap small molecules endowed with anti-myeloma activity by Taranto, Sara, Castelli, Riccardo, Marseglia, Giuseppe, Scalvini, Laura, Vacondio, Federica, Gianoncelli, Alessandra, Ribaudo, Giovanni, Faletti, Jessica, Gazzaroli, Giorgia, Rocca, Edoardo, Ronca, Roberto, Rusnati, Marco, Sacco, Antonio, Roccaro, Aldo Maria, Presta, Marco, Mor, Marco, Giacomini, Arianna, Rivara, Silvia

“…Fibroblast growth factors (FGFs) act as proangiogenic and mitogenic cytokines in several cancers, including multiple myeloma (MM). Indeed, corrupted FGF…”
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Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models by Sasso, Oscar, Moreno-Sanz, Guillermo, Martucci, Cataldo, Realini, Natalia, Dionisi, Mauro, Mengatto, Luisa, Duranti, Andrea, Tarozzo, Glauco, Tarzia, Giorgio, Mor, Marco, Bertorelli, Rosalia, Reggiani, Angelo, Piomelli, Daniele

“…The N-acylethanolamine acid amidase inhibitor ARN077 exerts profound antinociceptive effects in animal pain models by enhancing endogenous lipid signaling at…”
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Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3- b ]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor by Mugnaini, Claudia, Kostrzewa, Magdalena, Casini, Marta, Kumar, Poulami, Catallo, Valeria, Allarà, Marco, Guastaferro, Laura, Brizzi, Antonella, Paolino, Marco, Tafi, Andrea, Kapatais, Christelos, Giorgi, Gianluca, Vacondio, Federica, Mor, Marco, Corelli, Federico, Ligresti, Alessia

“…Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently,…”
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Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models by La Monica, Silvia, Vacondio, Federica, Eltayeb, Kamal, Lodola, Alessio, Volta, Francesco, Viglioli, Martina, Ferlenghi, Francesca, Galvani, Francesca, Galetti, Maricla, Bonelli, Mara, Fumarola, Claudia, Cavazzoni, Andrea, Flammini, Lisa, Verzè, Michela, Minari, Roberta, Petronini, Pier Giorgio, Tiseo, Marcello, Mor, Marco, Alfieri, Roberta

“…The EGFR tyrosine kinase inhibitor osimertinib has been approved for the first-line treatment of EGFR -mutated Non-Small Cell Lung Cancer (NSCLC) patients…”
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Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase by Ghidini, Andrea, Scalvini, Laura, Palese, Francesca, Lodola, Alessio, Mor, Marco, Piomelli, Daniele

“…N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) hydrolase that catalyses the intracellular deactivation of the endogenous analgesic…”
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Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors by Castelli, Riccardo, Giacomini, Arianna, Anselmi, Mattia, Bozza, Nicole, Vacondio, Federica, Rivara, Silvia, Matarazzo, Sara, Presta, Marco, Mor, Marco, Ronca, Roberto

“…NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. It was identified by virtual…”
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Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation by Fegley, Darren, Gaetani, Silvana, Duranti, Andrea, Tontini, Andrea, Mor, Marco, Tarzia, Giorgio, Piomelli, Daniele

“…Fatty acid amide hydrolase (FAAH) is an intracellular serine enzyme that catalyzes the hydrolysis of bioactive fatty acid ethanolamides such as anandamide and…”
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Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria by Elisi, Gian Marco, Bedini, Annalida, Scalvini, Laura, Carmi, Caterina, Bartolucci, Silvia, Lucini, Valeria, Scaglione, Francesco, Mor, Marco, Rivara, Silvia, Spadoni, Gilberto

“…-anilinoethylamides are a class of melatoninergic agents with the aniline portion mimicking the indole ring of the natural ligand and the ethylamide chain…”
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A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations by Lodola, Alessio, Branduardi, Davide, De Vivo, Marco, Capoferri, Luigi, Mor, Marco, Piomelli, Daniele, Cavalli, Andrea

“…The N-terminal nucleophile (Ntn) hydrolases are a superfamily of enzymes specialized in the hydrolytic cleavage of amide bonds. Even though several members of…”
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Modulation of anxiety through blockade of anandamide hydrolysis by Piomelli, Daniele, Kathuria, Satish, Gaetani, Silvana, Fegley, Darren, Valiño, Fernando, Duranti, Andrea, Tontini, Andrea, Mor, Marco, Tarzia, Giorgio, Rana, Giovanna La, Calignano, Antonio, Giustino, Arcangela, Tattoli, Maria, Palmery, Maura, Cuomo, Vincenzo

“…The psychoactive constituent of cannabis, Delta(9)-tetrahydrocannabinol, produces in humans subjective responses mediated by CB1 cannabinoid receptors,…”
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Amino Acid Conjugates of Lithocholic Acid As Antagonists of the EphA2 Receptor by Incerti, Matteo, Tognolini, Massimiliano, Russo, Simonetta, Pala, Daniele, Giorgio, Carmine, Hassan-Mohamed, Iftiin, Noberini, Roberta, Pasquale, Elena B, Vicini, Paola, Piersanti, Silvia, Rivara, Silvia, Barocelli, Elisabetta, Mor, Marco, Lodola, Alessio

“…The Eph receptor–ephrin system is an emerging target for the development of novel antiangiogenetic agents. We recently identified lithocholic acid (LCA) as a…”
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