Search Results - "MOORE, MELISSA J."

Redefining the Translational Status of 80S Monosomes by Heyer, Erin E., Moore, Melissa J.

“…Fully assembled ribosomes exist in two populations: polysomes and monosomes. While the former has been studied extensively, to what extent translation occurs…”
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The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion by Singh, Guramrit, Pratt, Gabriel, Yeo, Gene W, Moore, Melissa J

“…Throughout their lifetimes, messenger RNAs (mRNAs) associate with proteins to form ribonucleoproteins (mRNPs). Since the discovery of the first mRNP component…”
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The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus by Singh, Guramrit, Kucukural, Alper, Cenik, Can, Leszyk, John D., Shaffer, Scott A., Weng, Zhiping, Moore, Melissa J.

“…In addition to sculpting eukaryotic transcripts by removing introns, pre-mRNA splicing greatly impacts protein composition of the emerging mRNP. The exon…”
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Impact of lipid nanoparticle size on mRNA vaccine immunogenicity by Hassett, Kimberly J., Higgins, Jaclyn, Woods, Angela, Levy, Becca, Xia, Yan, Hsiao, Chiaowen Joyce, Acosta, Edward, Almarsson, Örn, Moore, Melissa J., Brito, Luis A.

“…Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and have shown promise for vaccine applications. Yet there are no published…”
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An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes by Li, Xin Zhiguo, Roy, Christian K., Dong, Xianjun, Bolcun-Filas, Ewelina, Wang, Jie, Han, Bo W., Xu, Jia, Moore, Melissa J., Schimenti, John C., Weng, Zhiping, Zamore, Phillip D.

“…Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transposons and enable gamete maturation. Mammalian…”
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DEBrowser: interactive differential expression analysis and visualization tool for count data by Kucukural, Alper, Yukselen, Onur, Ozata, Deniz M, Moore, Melissa J, Garber, Manuel

“…Sequencing data has become a standard measure of diverse cellular activities. For example, gene expression is accurately measured by RNA sequencing (RNA-Seq)…”
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mRNA structure regulates protein expression through changes in functional half-life by Mauger, David M., Cabral, B. Joseph, Presnyak, Vladimir, Su, Stephen V., Reid, David W., Goodman, Brooke, Link, Kristian, Khatwani, Nikhil, Reynders, John, Moore, Melissa J., McFadyen, Iain J.

“…Messenger RNAs (mRNAs) encode information in both their primary sequence and their higher order structure. The independent contributions of factors like codon…”
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The spliceosome: a flexible, reversible macromolecular machine by Hoskins, Aaron A., Moore, Melissa J.

“…With more than a hundred individual RNA and protein parts and a highly dynamic assembly and disassembly pathway, the spliceosome is arguably the most…”
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From Birth to Death: The Complex Lives of Eukaryotic mRNAs by Moore, Melissa J

“…Recent work indicates that the posttranscriptional control of eukaryotic gene expression is much more elaborate and extensive than previously thought, with…”
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Post-transcriptional regulation of gene expression in innate immunity by Carpenter, Susan, Ricci, Emiliano P., Mercier, Blandine C., Moore, Melissa J., Fitzgerald, Katherine A.

“…Key Points This Review summarizes post-transcriptional regulation in the innate immune response. We discuss the regulatory mechanisms that function at the…”
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Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides by Salomon, William E., Jolly, Samson M., Moore, Melissa J., Zamore, Phillip D., Serebrov, Victor

“…Argonaute proteins repress gene expression and defend against foreign nucleic acids using short RNAs or DNAs to specify the correct target RNA or DNA sequence…”
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Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals by Sharma, Upasna, Conine, Colin C., Shea, Jeremy M., Boskovic, Ana, Derr, Alan G., Bing, Xin Y., Belleannee, Clemence, Kucukural, Alper, Serra, Ryan W., Sun, Fengyun, Song, Lina, Carone, Benjamin R., Ricci, Emiliano P., Li, Xin Z., Fauquier, Lucas, Moore, Melissa J., Sullivan, Robert, Mello, Craig C., Garber, Manuel, Rando, Oliver J.

“…Several recent studies link parental environments to phenotypes in subsequent generations. In this work, we investigate the mechanism by which paternal diet…”
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Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines by Hassett, Kimberly J., Benenato, Kerry E., Jacquinet, Eric, Lee, Aisha, Woods, Angela, Yuzhakov, Olga, Himansu, Sunny, Deterling, Jessica, Geilich, Benjamin M., Ketova, Tatiana, Mihai, Cosmin, Lynn, Andy, McFadyen, Iain, Moore, Melissa J., Senn, Joseph J., Stanton, Matthew G., Almarsson, Örn, Ciaramella, Giuseppe, Brito, Luis A.

“…mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and…”
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A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes by Carpenter, Susan, Aiello, Daniel, Atianand, Maninjay K., Ricci, Emiliano P., Gandhi, Pallavi, Hall, Lisa L., Byron, Meg, Monks, Brian, Henry-Bezy, Meabh, Lawrence, Jeanne B., O'Neill, Luke A. J., Moore, Melissa J., Caffrey, Daniel R., Fitzgerald, Katherine A.

“…An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving…”
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The spliceosome: disorder and dynamics defined by Chen, Weijun, Moore, Melissa J

“…•Evolutionarily young spliceosomal proteins have high intrinsic disorder.•Spliceosome assembly is reversible and can occur by multiple pathways.•Reversible…”
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A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation by Atianand, Maninjay K., Hu, Wenqian, Satpathy, Ansuman T., Shen, Ying, Ricci, Emiliano P., Alvarez-Dominguez, Juan R., Bhatta, Ankit, Schattgen, Stefan A., McGowan, Jason D., Blin, Juliana, Braun, Joerg E., Gandhi, Pallavi, Moore, Melissa J., Chang, Howard Y., Lodish, Harvey F., Caffrey, Daniel R., Fitzgerald, Katherine A.

“…Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression. Although lincRNAs are expressed in immune cells, their functions in…”
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RNAi modulation of placental sFLT1 for the treatment of preeclampsia by Turanov, Anton A, Lo, Agnes, Hassler, Matthew R, Makris, Angela, Ashar-Patel, Ami, Alterman, Julia F, Coles, Andrew H, Haraszti, Reka A, Roux, Loic, Godinho, Bruno M D C, Echeverria, Dimas, Pears, Suzanne, Iliopoulos, Jim, Shanmugalingam, Renuka, Ogle, Robert, Zsengeller, Zsuzsanna K, Hennessy, Annemarie, Karumanchi, S Ananth, Moore, Melissa J, Khvorova, Anastasia

“…Preeclampsia, a hypertension condition with no approved therapies, is treated in monkeys by gene silencing in the placenta. Preeclampsia is a placentally…”
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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo by Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Davis, Sarah M, Morrissey, David V, Zamore, Phillip D, Karumanchi, S Ananth, Moore, Melissa J, Aronin, Neil, Khvorova, Anastasia

“…Abstract Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable…”
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Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes by Sephton, Chantelle F., Cenik, Can, Kucukural, Alper, Dammer, Eric B., Cenik, Basar, Han, YuHong, Dewey, Colleen M., Roth, Frederick P., Herz, Joachim, Peng, Junmin, Moore, Melissa J., Yu, Gang

“…TAR DNA-binding protein 43 (TDP-43) is associated with a spectrum of neurodegenerative diseases. Although TDP-43 resembles heterogeneous nuclear…”
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Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways by Kovalak, Carrie, Donovan, Scott, Bicknell, Alicia A, Metkar, Mihir, Moore, Melissa J

“…Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through…”
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