Search Results - "MOORE, L. MERKLE"
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A new animal model of insulin-glucose dynamics in the intraperitoneal space enhances closed-loop control performance
Published in Journal of process control (01-04-2019)“…•State-of-the-art control algorithms delivering insulin subcutaneously (SC) to treat type 1 diabetes (T1D) exhibit slow diffusion and lag.•Alternative insulin…”
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Case Report: Syndrome of Remitting Seronegative Symmetrical Synovitis with Pitting Edema—A Rare but Treatable Condition in Palliative Medicine
Published in Palliative medicine reports (01-12-2022)“…The syndrome of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare diagnosis that is often missed due to lack of both definitive…”
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The kinetics of glucagon action on the liver during insulin-induced hypoglycemia
Published in American journal of physiology: endocrinology and metabolism (01-05-2020)“…Glucagon's effect on hepatic glucose production (HGP), under hyperglycemic conditions, is time dependent such that after an initial burst of HGP, it slowly…”
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1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model
Published in Diabetes (New York, N.Y.) (01-06-2019)“…With the recent interest in sympathetic modulation as a way to improve insulin sensitivity and insulin secretion, it is important to assess the safety of the…”
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Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs
Published in Diabetes, obesity & metabolism (01-01-2019)“…Aims Current therapy fails to emulate rapid (first‐phase) insulin release in relation to a meal, a key defect in types 1 and 2 diabetes. We aimed to quantify…”
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Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors
Published in Diabetes (New York, N.Y.) (01-07-2018)“…The incretin effect, which is defective in individuals with T2D, involves the secretion of GLP-1 and GIP when glucose is given orally, but not when it is…”
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Basal Oral Insulin Analog I338 Enhances Meal-Related Hepatic Glucose Disposal
Published in Diabetes (New York, N.Y.) (01-07-2018)“…Oral insulin avoids the need for injections, and insulin enters via the hepatic portal vein (Po), the normal route of secretion. We examined the effect of…”
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