Search Results - "MOOKHTIAR, K. A"

Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus by Brown, K. S., Kalinowski, S. S., Megill, J. R., Durham, S. K., Mookhtiar, K. A.

“…Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus. K S Brown , S S Kalinowski , J R Megill , S K Durham and K A Mookhtiar…”
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Yeast squalene synthase: a mechanism for addition of substrates and activation by NADPH by Mookhtiar, K.A, Kalinowski, S.S, Zhang, D, Poulter, C.D

“…Squalene synthase catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to give presqualene diphosphate (PSPP) and the subsequent reductive…”
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Orally Active Squalene Synthase Inhibitors:  Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety by Dickson, John K, Biller, Scott A, Magnin, David R, Petrillo, Edward W, Hillyer, John W, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Gregg, Richard E, Harrity, Thomas W, Jolibois, Kern G, Kalinowski, Stephen S, Kunselman, Lori K, Mookhtiar, Kasim A, Ciosek, Carl P

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Heterologous expression and characterization of rat liver glucokinase regulatory protein by Mookhtiar, K. A., Kalinowski, S. S., Brown, K. S., Tsay, Y. H., Smith-Monroy, C., Robinson, G. W.

“…Heterologous expression and characterization of rat liver glucokinase regulatory protein. K A Mookhtiar , S S Kalinowski , K S Brown , Y H Tsay , C…”
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Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus by BROWN, K. S, KALINOWSKI, S. S, MEGILL, J. R, DURHAM, S. K, MOOKHTIAR, K. A

“…Glucokinase (GK) plays a central role in the sensing of glucose in pancreatic beta-cells and parenchymal cells of the liver. Glucokinase regulatory protein is…”
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Mice Mutant for Glucokinase Regulatory Protein Exhibit Decreased Liver Glucokinase: A Sequestration Mechanism in Metabolic Regulation by Farrelly, Dennis, Brown, Karen S., Tieman, Aaron, Ren, Jianming, Lira, Sergio A., Hagan, Deborah, Gregg, Richard, Mookhtiar, Kasim A., Hariharan, Narayanan

“…The importance of glucokinase (GK; EC 2.7.1.12) in glucose homeostasis has been demonstrated by the association of GK mutations with diabetes mellitus in…”
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Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase by Mallya, Satish K, Mookhtiar, Kasim A, Gao, Yi, Brew, Keith, Dioszegi, Marianna, Birkedal-Hansen, Henning, Van Wart, Harold E

“…A series of experiments has been carried out to characterize 58-kDa human neutrophil collagenase (HNC) and compare it with human fibroblast collagenase (HFC)…”
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Glucolipsin A and B, two new glucokinase activators produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii by Qian-Cutrone, J, Ueki, T, Huang, S, Mookhtiar, K A, Ezekiel, R, Kalinowski, S S, Brown, K S, Golik, J, Lowe, S, Pirnik, D M, Hugill, R, Veitch, J A, Klohr, S E, Whitney, J L, Manly, S P

“…During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acyl CoA…”
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Inhibition of human collagenases by sulfur-based substrate analogs by Schwartz, M A, Venkataraman, S, Ghaffari, M A, Libby, A, Mookhtiar, K A, Mallya, S K, Birkedal-Hansen, H, Van Wart, H E

“…A series of sulfhydryl and novel sulfur-based substrate-analog inhibitors has been synthesized and tested against human fibroblast and neutrophil collagenases…”
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Purification to homogeneity of latent and active 58-kilodalton forms of human neutrophil collagenase by Mookhtiar, Kasim A, Van Wart, Harold E

“…Latent and active 58-kDa forms of human neutrophil collagenase (HNC) have been purified to homogeneity. Buffy coats were extracted in the presence and absence…”
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Processivity of T7 RNA polymerase requires the C-terminal Phe882-Ala883-COO- or "foot" by Mookhtiar, Kasim A, Peluso, Paul S, Muller, Daniel K, Dunn, John J, Coleman, Joseph E

“…The role of the C-terminal Phe882-Ala883 residues of bacteriophage T7 RNA polymerase in specific transcription has been investigated by means of site-directed…”
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Phosphonamidate inhibitors of human neutrophil collagenase by Mookhtiar, Kasim A, Marlowe, Charles K, Bartlett, Paul A, Van Wart, Harold E

“…A series of phosphonamidates has been synthesized and shown to inhibit human neutrophil collagenase. The compounds all have sequences patterned after the…”
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Ketone-substrate analogues of Clostridium histolyticum collagenases: tight-binding transition-state analogue inhibitors by Mookhtiar, Kasim A., Grobelny, Damian, Galardy, Richard E., Van Wart, Harold E.

“…A series of ketone-substrate analogues has been synthesized for the two classes of collagenases from Clostridium histolyticum and shown to be competitive…”
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Mode of hydrolysis of collagen-like peptides by class I and class II Clostridium histolyticum collagenases: evidence for both endopeptidase and tripeptidylcarboxypeptidase activities by Mookhtiar, Kasim, Steinbrink, D. Randall, Van Wart, Harold E

“…The action of three class I (beta, gamma, and eta) and three class II (delta, epsilon, and zeta) collagenases from Clostridium histolyticum on two series of…”
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Functional constituents of the active site of human neutrophil collagenase by Mookhtiar, K A, Wang, F, Van Wart, H E

“…A series of chemical modification reactions has been carried out to identify functional constituents of the active site of human neutrophil collagenase. The…”
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Initiation, Elongation, and Processivity of Carboxyl-Terminal Mutants of T7 RNA Polymerase by Gardner, Lisa P, Mookhtiar, Kasim A, Coleman, Joseph E

“…Bacteriophage T7 RNA polymerase is a single-subunit enzyme which has a C-terminal amino acid sequence of Phe-Ala-Phe-Ala883 (FAFA883). Closely related…”
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Heterologous expression and characterization of rat liver glucokinase regulatory protein by MOOKHTIAR, K. A, KALINOWSKI, S. S, BROWN, K. S, YIM HA TSAY, SMITH-MONROY, C, ROBINSON, G. W

“…Glucokinase is a critical component of the physiological glucose sensor found in cell types that are responsive to changes in plasma glucose levels. The acute…”
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Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo by Ciosek, C P, Magnin, D R, Harrity, T W, Logan, J V, Dickson, J K, Gordon, E M, Hamilton, K A, Jolibois, K G, Kunselman, L K, Lawrence, R M

“…Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl diphosphate to form squalene at the final branchpoint of the cholesterol…”
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Mechanism of Inhibition of Yeast Squalene Synthase by Substrate Analog Inhibitors by Kalinowski, Stephen S., Mookhtiar, Kasim A.

“…Squalene synthase catalyzes the reductive condensation of two identical substrate molecules, farnesyl diphosphate, to the hydrocarbon squalene via an…”
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Limited proteolysis of type I collagen at hyperreactive sites by class I and II Clostridium histolyticum collagenases: complementary digestion patterns by French, Mark F, Mookhtiar, Kasim A, Van Wart, Harold E

“…The initial proteolytic events in the hydrolysis of rat tendon type I collagen by the class I and II collagenases from Clostridium histolyticum have been…”
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