Search Results - "MOOK, R"

Evaluation of locked nucleic acid–modified small interfering RNA in vitro and in vivo by Mook, Olaf R, Baas, Frank, de Wissel, Marit B, Fluiter, Kees

“…RNA interference has become widely used as an experimental tool to study gene function. In addition, small interfering RNA (siRNA) may have great potential for…”
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Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21R110 by Hengeveld, Paul J., Ertem, Y. Emre, Dubois, Julie M. N., Mellink, Clemens H. M., van der Kevie-Kersemaekers, Anne-Marie, Evers, Ludo M., Heezen, Kim, Kolijn, P. Martijn, Mook, Olaf R. F., Motazacker, M. Mahdi, Nasserinejad, Kazem, Kersting, S., Westerweel, Peter E., Niemann, Carsten U., Kater, Arnon P., Langerak, Anton W., Levin, Mark-David

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Large next-generation sequencing gene panels in genetic heart disease: yield of pathogenic variants and variants of unknown significance by van Lint, F. H. M., Mook, O. R. F., Alders, M., Bikker, H., Lekanne dit Deprez, R. H., Christiaans, I.

“…Background Genetic heterogeneity is common in inherited cardiac diseases. Next-generation sequencing gene panels are therefore suitable for genetic diagnosis…”
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Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo by Laursen, Maria B, Pakula, Malgorzata M, Gao, Shan, Fluiter, Kees, Mook, Olaf R, Baas, Frank, Langklaer, Niels, Wengel, Suzy L, Wengel, Jesper, Kjems, Jørgen, Bramsen, Jesper B

“…Small interfering RNAs (siRNAs) are now established as a favourite tool to reduce gene expression by RNA interference (RNAi) in mammalian cell culture…”
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The Comprehensive Arthroscopic Management Procedure for Treatment of Glenohumeral Osteoarthritis by Mook, William R., M.D, Petri, Maximilian, M.D, Greenspoon, Joshua A., B.Sc, Millett, Peter J., M.D., M.Sc

“…Abstract Younger, high-demand patients who are less suitable for joint replacement procedures are often affected by advanced glenohumeral osteoarthritis. There…”
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Large next-generation sequencing gene panels in genetic heart disease: challenges in clinical practice by Christiaans, I., Mook, O. R. F., Alders, M., Bikker, H., Lekanne dit Deprez, R. H.

“…Background Next-generation sequencing gene panels are increasingly used for genetic diagnosis in inherited cardiac diseases. Besides pathogenic variants,…”
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TGFBR1 Variants Can Associate with Non-Syndromic Congenital Heart Disease without Aortopathy by Alaamery, Manal, Albesher, Nour, Alhabshan, Fahad, Barnett, Phil, Salim Kabbani, Mohamed, Chaikhouni, Farah, Ilgun, Aho, Mook, Olaf R. F., Alsaif, Hessa, Christoffels, Vincent M., van Tintelen, Peter, Wilde, Arthur A. M., Houweling, Arjan C., Massadeh, Salam, Postma, Alex V.

“…Background: Congenital heart diseases (CHD) are the most common congenital malformations in newborns and remain the leading cause of mortality among infants…”
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Hip Capsular Reconstruction Using Dermal Allograft by Chahla, Jorge, M.D, Dean, Chase S., M.D, Soares, Eduardo, M.D, Mook, William R., M.D, Philippon, Marc J., M.D

“…Abstract Because hip arthroscopic procedures are increasing in number, complications related to the operation itself are starting to emerge. Whereas the…”
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Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes by Drewniak, Agata, van Raam, Bram J., Geissler, Judy, Tool, Anton T.J., Mook, Olaf R.F., van den Berg, Timo K., Baas, Frank, Kuijpers, Taco W.

“…The treatment of healthy donors with granulocyte colony-stimulating factor (G-CSF) and dexamethasone results in sufficient numbers of circulating granulocytes…”
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Diagnosis and Management of Periprosthetic Shoulder Infections by Mook, William R, Garrigues, Grant E

“…➤ The unique bacterial flora of the shoulder present diagnostic and treatment challenges that are distinct from those seen with failed hip and knee…”
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The Incidence of Propionibacterium acnes in Open Shoulder Surgery: A Controlled Diagnostic Study by Mook, William R, Klement, Mitchell R, Green, Cynthia L, Hazen, Kevin C, Garrigues, Grant E

“…BACKGROUND:Propionibacterium acnes has arisen as the most common microorganism identified at the time of revision shoulder arthroplasty. There is limited…”
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A Serum-Resistant Cytofectin for Cellular Delivery of Antisense Oligodeoxynucleotides and Plasmid DNA by Lewis, Jason G., Lin, Kuei-Ying, Kothavale, Avinash, Flanagan, W. Michael, Matteucci, Mark D., DePrince, Randolph B., Mook, Robert A., Hendren, R. Wayne, Wagner, Richard W.

“…Development of antisense technology has focused in part on creating improved methods for delivering oligodeoxynucleotides (ODNs) to cells. In this report, we…”
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Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1 by CHEUNG, M, KUNTZ, K. W, SMITH, J. L, SMITH, G. K, LANSING, T. J, MOOK, R. A, POBANZ, M, SALOVICH, J. M, WILSON, B. J, ANDREWS, C. W, SHEWCHUK, L. M, EPPERLY, A. H, HASSLER, D. F, LEESNITZER, M. A

“…The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported…”
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Pearls & Oy-sters: Transient neurologic events in a patient with leptomeningeal metastases by Stretz, Christoph, Mook, Amanda R, Zhang, Yan

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Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer by Fluiter, Kees, Mook, Olaf R F, Vreijling, Jeroen, Langkjaer, Niels, Højland, Torben, Wengel, Jesper, Baas, Frank

“…Stability against nucleases, affinity for the targeted mRNA and the ability to recruit RNase H are prerequisites for antisense oligonucleotide (AON)…”
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Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2A by Mook, O R F, Baas, F, de Wissel, M B, Fluiter, K

“…Cancer is one of the diseases for which RNA interference is a potential therapeutic approach. Genes involved in the promotion or maintenance of tumor growth…”
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Clinical and Anatomic Predictors of Outcomes After the Latarjet Procedure for the Treatment of Anterior Glenohumeral Instability With Combined Glenoid and Humeral Bone Defects by Mook, William R., Petri, Maximilian, Greenspoon, Joshua A., Horan, Marilee P., Dornan, Grant J., Millett, Peter J.

“…Background: The Latarjet procedure for the treatment of recurrent anterior shoulder instability is highly successful, but reasons for failure are often…”
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Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression by Naue, Jana, Hoefsloot, Huub C.J., Mook, Olaf R.F., Rijlaarsdam-Hoekstra, Laura, van der Zwalm, Marloes C.H., Henneman, Peter, Kloosterman, Ate D., Verschure, Pernette J.

“…•An epigenetic age prediction tool for blood was developed based on MPS, and the DNA methylation levels of 13 markers.•Random forest regression (RFR) was used…”
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Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome by Alders, Mariëlle, Al-Gazali, Lihadh, Cordeiro, Isabelle, Dallapiccola, Bruno, Garavelli, Livia, Tuysuz, Beyhan, Salehi, Faranak, Haagmans, Martin A., Mook, Olaf R., Majoie, Charles B., Mannens, Marcel M., Hennekam, Raoul C.

“…The Hennekam lymphangiectasia–lymphedema syndrome is a genetically heterogeneous disorder. It can be caused by mutations in CCBE1 which are found in…”
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Multiple-Ligament Knee Injuries: A Systematic Review of the Timing of Operative Intervention and Postoperative Rehabilitation by Mook, William R, Miller, Mark D, Diduch, David R, Hertel, Jay, Boachie-Adjei, Yaw, Hart, Joseph M

“…BackgroundTraumatic knee dislocations that result in multiple-ligament knee injuries are unusual and are poorly studied. We are not aware of any prospective…”
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