Search Results - "MONTINE, KATHLEEN S"

Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer’s disease by Huang, Zhi, Merrihew, Gennifer E., Larson, Eric B., Park, Jea, Plubell, Deanna, Fox, Edward J., Montine, Kathleen S., Latimer, Caitlin S., Dirk Keene, C., Zou, James Y., MacCoss, Michael J., Montine, Thomas J.

“…Resilience to Alzheimer’s disease is an uncommon combination of high disease burden without dementia that offers valuable insights into limiting clinical…”
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Whole genome deconvolution unveils Alzheimer’s resilient epigenetic signature by Berson, Eloise, Sreenivas, Anjali, Phongpreecha, Thanaphong, Perna, Amalia, Grandi, Fiorella C., Xue, Lei, Ravindra, Neal G., Payrovnaziri, Neelufar, Mataraso, Samson, Kim, Yeasul, Espinosa, Camilo, Chang, Alan L., Becker, Martin, Montine, Kathleen S., Fox, Edward J., Chang, Howard Y., Corces, M. Ryan, Aghaeepour, Nima, Montine, Thomas J.

“…Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq) accurately depicts the chromatin regulatory state and altered mechanisms guiding gene…”
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Understanding the molecular basis of resilience to Alzheimer's disease by Montine, Kathleen S, Berson, Eloïse, Phongpreecha, Thanaphong, Huang, Zhi, Aghaeepour, Nima, Zou, James Y, MacCoss, Michael J, Montine, Thomas J

“…The cellular and molecular distinction between brain aging and neurodegenerative disease begins to blur in the oldest old. Approximately 15-25% of observations…”
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Mass synaptometry: High-dimensional multi parametric assay for single synapses by Gajera, Chandresh R., Fernandez, Rosemary, Postupna, Nadia, Montine, Kathleen S., Fox, Edward J., Tebaykin, Dmitry, Angelo, Michael, Bendall, Sean C., Keene, C. Dirk, Montine, Thomas J.

“…•Mass synaptometry method for single synapse multiplexed molecular profiling.•Synapse by Time Of Flight (SynTOF) panel of 34 antibodies for wide…”
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Prostaglandin E2 Receptor Subtype 2 Regulation of Scavenger Receptor CD36 Modulates Microglial Aβ42 Phagocytosis by Li, Xianwu, Melief, Erica, Postupna, Nadia, Montine, Kathleen S, Keene, C. Dirk, Montine, Thomas J

“…Recent studies underline the potential relevance of microglial innate immune activation in Alzheimer disease. Primary mouse microglia that lack prostaglandin…”
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Cross-species comparative analysis of single presynapses by Berson, Eloïse, Gajera, Chandresh R., Phongpreecha, Thanaphong, Perna, Amalia, Bukhari, Syed A., Becker, Martin, Chang, Alan L., De Francesco, Davide, Espinosa, Camilo, Ravindra, Neal G., Postupna, Nadia, Latimer, Caitlin S., Shively, Carol A., Register, Thomas C., Craft, Suzanne, Montine, Kathleen S., Fox, Edward J., Keene, C. Dirk, Bendall, Sean C., Aghaeepour, Nima, Montine, Thomas J.

“…Comparing brain structure across species and regions enables key functional insights. Leveraging publicly available data from a novel mass cytometry-based…”
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Single-cell peripheral immunoprofiling of lewy body and Parkinson's disease in a multi-site cohort by Phongpreecha, Thanaphong, Mathi, Kavita, Cholerton, Brenna, Fox, Eddie J, Sigal, Natalia, Espinosa, Camilo, Reincke, Momsen, Chung, Philip, Hwang, Ling-Jen, Gajera, Chandresh R, Berson, Eloise, Perna, Amalia, Xie, Feng, Shu, Chi-Hung, Hazra, Debapriya, Channappa, Divya, Dunn, Jeffrey E, Kipp, Lucas B, Poston, Kathleen L, Montine, Kathleen S, Maecker, Holden T, Aghaeepour, Nima, Montine, Thomas J

“…Multiple lines of evidence support peripheral organs in the initiation or progression of Lewy body disease (LBD), a spectrum of neurodegenerative diagnoses…”
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TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study by Flanagan, Margaret E, Cholerton, Brenna, Latimer, Caitlin S, Hemmy, Laura S, Edland, Steven D, Montine, Kathleen S, White, Lon R, Montine, Thomas J

“…Transactive response binding protein-43 (TDP-43) cytoplasmic neuronal and glial aggregates (pathologic TDP-43) have been described in multiple brain diseases…”
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Quantitative estimate of cognitive resilience and its medical and genetic associations by Phongpreecha, Thanaphong, Godrich, Dana, Berson, Eloise, Espinosa, Camilo, Kim, Yeasul, Cholerton, Brenna, Chang, Alan L, Mataraso, Samson, Bukhari, Syed A, Perna, Amalia, Yakabi, Koya, Montine, Kathleen S, Poston, Kathleen L, Mormino, Elizabeth, White, Lon, Beecham, Gary, Aghaeepour, Nima, Montine, Thomas J

“…We have proposed that cognitive resilience (CR) counteracts brain damage from Alzheimer's disease (AD) or AD-related dementias such that older individuals who…”
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Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics by Montine, Thomas J, Sonnen, Joshua A, Montine, Kathleen S, Crane, Paul K, Larson, Eric B

“…The Adult Changes in Thought (ACT) study is a longitudinal population-based prospective cohort study of brain aging and incident dementia in the Seattle…”
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Single-cell spatial proteomic imaging for human neuropathology by Vijayaragavan, Kausalia, Cannon, Bryan J, Tebaykin, Dmitry, Bossé, Marc, Baranski, Alex, Oliveria, J P, Bukhari, Syed A, Mrdjen, Dunja, Corces, M Ryan, McCaffrey, Erin F, Greenwald, Noah F, Sigal, Yari, Marquez, Diana, Khair, Zumana, Bruce, Trevor, Goldston, Mako, Bharadwaj, Anusha, Montine, Kathleen S, Angelo, R Michael, Montine, Thomas J, Bendall, Sean C

“…Neurodegenerative disorders are characterized by phenotypic changes and hallmark proteopathies. Quantifying these in archival human brain tissues remains…”
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Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein by Wang, Qin, Woltjer, Randall L, Cimino, P. J, Pan, Catherine, Montine, Kathleen S, Zhang, Jing, Montine, Thomas J

“…ABSTRACT We performed proteomic analysis of neurofibrillary tangles (NFTs) obtained by laser capture microdissection from pyramidal neurons in hippocampal…”
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Biomarkers for cognitive impairment and dementia in elderly people by Sonnen, Joshua A, MD, Montine, Kathleen S, PhD, Quinn, Joseph F, MD, Kaye, Jeffrey A, MD, Breitner, John CS, MD, Montine, Thomas J, MD

“…Summary The threat of a looming pandemic of dementia in elderly people highlights the compelling need for the development and validation of biomarkers that can…”
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Unveiling Resilience to Alzheimer’s Disease: Insights From Brain Regional Proteomic Markers by Huang, Zhi, Merrihew, Gennifer E, Larson, Eric B, Park, Jea, Plubell, Deanna, Fox, Edward J, Montine, Kathleen S, Keene, C Dirk, Latimer, Caitlin S, Zou, James Y, MacCoss, Michael J, Montine, Thomas J

“…Studying proteomics data of the human brain could offer numerous insights into unraveling the signature of resilience to Alzheimer’s disease. In our previous…”
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Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation by Cudaback, Eiron, Li, Xianwu, Yang, Yue, Yoo, Thomas, Montine, Kathleen S, Craft, Suzanne, Montine, Thomas J, Keene, Christopher Dirk

“…Inheritance of the human ε4 allele of the apolipoprotein (apo) E gene (APOE) significantly increases the risk of developing Alzheimer's disease (AD), in…”
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Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein by Jin, Jinghua, Shie, Feng-Shiun, Liu, Jun, Wang, Yan, Davis, Jeanne, Schantz, Aimee M, Montine, Kathleen S, Montine, Thomas J, Zhang, Jing

“…The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of…”
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Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity by Shie, Feng-Shiun, Montine, Kathleen S., Breyer, Richard M., Montine, Thomas J.

“…Prostaglandin (PG) E2 acts via four functionally antagonistic E‐prostanoid (EP) receptors that are expressed on multiple cell types in the nervous system;…”
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Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases by Montine, Kathleen S, Quinn, Joseph F, Zhang, Jing, Fessel, Joshua P, Roberts, L.Jackson, Morrow, Jason D, Montine, Thomas J

“…Lipid peroxidation is a major outcome of free radical-mediated injury to brain, where it directly damages membranes and generates a number of oxidized…”
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Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases by Corces, M. Ryan, Shcherbina, Anna, Kundu, Soumya, Gloudemans, Michael J., Frésard, Laure, Granja, Jeffrey M., Louie, Bryan H., Eulalio, Tiffany, Shams, Shadi, Bagdatli, S. Tansu, Mumbach, Maxwell R., Liu, Boxiang, Montine, Kathleen S., Greenleaf, William J., Kundaje, Anshul, Montgomery, Stephen B., Chang, Howard Y., Montine, Thomas J.

“…Genome-wide association studies of neurological diseases have identified thousands of variants associated with disease phenotypes. However, most of these…”
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An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues by Corces, M Ryan, Trevino, Alexandro E, Hamilton, Emily G, Greenside, Peyton G, Sinnott-Armstrong, Nicholas A, Vesuna, Sam, Satpathy, Ansuman T, Rubin, Adam J, Montine, Kathleen S, Wu, Beijing, Kathiria, Arwa, Cho, Seung Woo, Mumbach, Maxwell R, Carter, Ava C, Kasowski, Maya, Orloff, Lisa A, Risca, Viviana I, Kundaje, Anshul, Khavari, Paul A, Montine, Thomas J, Greenleaf, William J, Chang, Howard Y

“…The Omni-ATAC protocol improves the signal-to-background ratio in chromatin accessibility profiles and is suitable for a range of cell lines and primary cell…”
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