Search Results - "MONTEFIORI, David"

Measuring HIV neutralization in a luciferase reporter gene assay by Montefiori, David C

“…Neutralizing antibody (NAb) assays for human immunodeficiency virus (HIV) are used to study the immune response in infected individuals, to examine monoclonal…”
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Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351 by Shen, Xiaoying, Tang, Haili, Pajon, Rolando, Smith, Gale, Glenn, Gregory M, Shi, Wei, Korber, Bette, Montefiori, David C

“…An analysis of cross-reactive viral binding and neutralization of emerging SARS-CoV-2 variants suggests that the mRNA-1273 and NVX-CoV2373 vaccines elicit…”
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A Bivalent Omicron-Containing Booster Vaccine against Covid-19 by Chalkias, Spyros, Harper, Charles, Vrbicky, Keith, Walsh, Stephen R., Essink, Brandon, Brosz, Adam, McGhee, Nichole, Tomassini, Joanne E., Chen, Xing, Chang, Ying, Sutherland, Andrea, Montefiori, David C., Girard, Bethany, Edwards, Darin K., Feng, Jing, Zhou, Honghong, Baden, Lindsey R., Miller, Jacqueline M., Das, Rituparna

“…When given as a second booster, a bivalent vaccine including sequences from the Wuhan-Hu-1 and omicron BA.1 viral strains induced higher levels of neutralizing…”
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SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines by Shen, Xiaoying, Tang, Haili, McDanal, Charlene, Wagh, Kshitij, Fischer, William, Theiler, James, Yoon, Hyejin, Li, Dapeng, Haynes, Barton F., Sanders, Kevin O., Gnanakaran, Sandrasegaram, Hengartner, Nick, Pajon, Rolando, Smith, Gale, Glenn, Gregory M., Korber, Bette, Montefiori, David C.

“…All current vaccines for COVID-19 utilize ancestral SARS-CoV-2 spike with the goal of generating protective neutralizing antibodies. The recent emergence and…”
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D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization by Weissman, Drew, Alameh, Mohamad-Gabriel, de Silva, Thushan, Collini, Paul, Hornsby, Hailey, Brown, Rebecca, LaBranche, Celia C., Edwards, Robert J., Sutherland, Laura, Santra, Sampa, Mansouri, Katayoun, Gobeil, Sophie, McDanal, Charlene, Pardi, Norbert, Hengartner, Nick, Lin, Paulo J.C., Tam, Ying, Shaw, Pamela A., Lewis, Mark G., Boesler, Carsten, Şahin, Uğur, Acharya, Priyamvada, Haynes, Barton F., Korber, Bette, Montefiori, David C.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired a D614G mutation early in the pandemic that confers greater infectivity…”
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SnapShot: SARS-CoV-2 antibodies by Montefiori, David C., Acharya, Priyamvada

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Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections by Wagh, Kshitij, Seaman, Michael S, Zingg, Marshall, Fitzsimons, Tomas, Barouch, Dan H, Burton, Dennis R, Connors, Mark, Ho, David D, Mascola, John R, Nussenzweig, Michel C, Ravetch, Jeffrey, Gautam, Rajeev, Martin, Malcolm A, Montefiori, David C, Korber, Bette

“…ClinicalTrials.gov NCT02960581…”
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The role of antibodies in HIV vaccines by Mascola, John R, Montefiori, David C

“…Licensed vaccines against viral diseases generate antibodies that neutralize the infecting virus and protect against infection or disease. Similarly, an…”
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Structural diversity of the SARS-CoV-2 Omicron spike by Gobeil, Sophie M.-C., Henderson, Rory, Stalls, Victoria, Janowska, Katarzyna, Huang, Xiao, May, Aaron, Speakman, Micah, Beaudoin, Esther, Manne, Kartik, Li, Dapeng, Parks, Rob, Barr, Maggie, Deyton, Margaret, Martin, Mitchell, Mansouri, Katayoun, Edwards, Robert J., Eaton, Amanda, Montefiori, David C., Sempowski, Gregory D., Saunders, Kevin O., Wiehe, Kevin, Williams, Wilton, Korber, Bette, Haynes, Barton F., Acharya, Priyamvada

“…Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential…”
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Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection by Wagh, Kshitij, Bhattacharya, Tanmoy, Williamson, Carolyn, Robles, Alex, Bayne, Madeleine, Garrity, Jetta, Rist, Michael, Rademeyer, Cecilia, Yoon, Hyejin, Lapedes, Alan, Gao, Hongmei, Greene, Kelli, Louder, Mark K, Kong, Rui, Karim, Salim Abdool, Burton, Dennis R, Barouch, Dan H, Nussenzweig, Michel C, Mascola, John R, Morris, Lynn, Montefiori, David C, Korber, Bette, Seaman, Michael S

“…The identification of a new generation of potent broadly neutralizing HIV-1 antibodies (bnAbs) has generated substantial interest in their potential use for…”
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Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection by HRABER, Peter, SEAMAN, Michael S, BAILER, Robert T, MASCOLA, John R, MONTEFIORI, David C, KORBER, Bette T

“…Studies of neutralizing antibodies in HIV-1 infected individuals provide insights into the quality of the response that should be possible to elicit with…”
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Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis by Choi, Angela, Koch, Matthew, Wu, Kai, Chu, Laurence, Ma, LingZhi, Hill, Anna, Nunna, Naveen, Huang, Wenmei, Oestreicher, Judy, Colpitts, Tonya, Bennett, Hamilton, Legault, Holly, Paila, Yamuna, Nestorova, Biliana, Ding, Baoyu, Montefiori, David, Pajon, Rolando, Miller, Jacqueline M., Leav, Brett, Carfi, Andrea, McPhee, Roderick, Edwards, Darin K.

“…The emergence of SARS-CoV-2 variants of concern (VOCs) and variants of interest (VOIs) with decreased susceptibility to neutralization has generated interest…”
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Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C by Klasse, P J, LaBranche, Celia C, Ketas, Thomas J, Ozorowski, Gabriel, Cupo, Albert, Pugach, Pavel, Ringe, Rajesh P, Golabek, Michael, van Gils, Marit J, Guttman, Miklos, Lee, Kelly K, Wilson, Ian A, Butera, Salvatore T, Ward, Andrew B, Montefiori, David C, Sanders, Rogier W, Moore, John P

“…We have investigated the immunogenicity in rabbits of native-like, soluble, recombinant SOSIP.664 trimers based on the env genes of four isolates of human…”
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Antibody‐virus co‐evolution in HIV infection: paths for HIV vaccine development by Bonsignori, Mattia, Liao, Hua‐Xin, Gao, Feng, Williams, Wilton B., Alam, S. Munir, Montefiori, David C., Haynes, Barton F.

“…Summary Induction of HIV‐1 broadly neutralizing antibodies (bnAbs) to date has only been observed in the setting of HIV‐1 infection, and then only years after…”
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Neutralization tiers of HIV-1 by Montefiori, David C, Roederer, Mario, Morris, Lynn, Seaman, Michael S

“…PURPOSE OF REVIEWHIV-1 isolates are often classified on the basis of neutralization ‘tier’ phenotype. Tier classification has important implications for the…”
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The SARS-CoV-2 Spike variant D614G favors an open conformational state by Mansbach, Rachael A, Chakraborty, Srirupa, Nguyen, Kien, Montefiori, David C, Korber, Bette, Gnanakaran, S

“…The COVID-19 (coronavirus disease 2019) pandemic underwent a rapid transition with the emergence of a dominant viral variant (from the "D-form" to the…”
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Bispecific Antibodies Against HIV by Montefiori, David C.

“…Synergistic bispecific antibodies against HIV exhibit extraordinary potency and breadth of neutralization as promising candidates for treatment and prevention…”
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A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice by Martinez, David R, Schäfer, Alexandra, Gobeil, Sophie, Li, Dapeng, De la Cruz, Gabriela, Parks, Robert, Lu, Xiaozhi, Barr, Maggie, Stalls, Victoria, Janowska, Katarzyna, Beaudoin, Esther, Manne, Kartik, Mansouri, Katayoun, Edwards, Robert J, Cronin, Kenneth, Yount, Boyd, Anasti, Kara, Montgomery, Stephanie A, Tang, Juanjie, Golding, Hana, Shen, Shaunna, Zhou, Tongqing, Kwong, Peter D, Graham, Barney S, Mascola, John R, Montefiori, David C, Alam, S Munir, Sempowski, Gregory, Sempowski, Gregory D, Khurana, Surender, Wiehe, Kevin, Saunders, Kevin O, Acharya, Priyamvada, Haynes, Barton F, Baric, Ralph S

“…Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2), including SARS-CoV-2 variants of concern, can cause deadly infections. The…”
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Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1 by Sarzotti-Kelsoe, Marcella, Bailer, Robert T., Turk, Ellen, Lin, Chen-li, Bilska, Miroslawa, Greene, Kelli M., Gao, Hongmei, Todd, Christopher A., Ozaki, Daniel A., Seaman, Michael S., Mascola, John R., Montefiori, David C.

“…The TZM-bl assay measures antibody-mediated neutralization of HIV-1 as a function of reductions in HIV-1 Tat-regulated firefly luciferase (Luc) reporter gene…”
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Towards a population-based threshold of protection for COVID-19 vaccines by Goldblatt, David, Fiore-Gartland, Andrew, Johnson, Marina, Hunt, Adam, Bengt, Christopher, Zavadska, Dace, Snipe, Hilda Darta, Brown, Jeremy S., Workman, Lesley, Zar, Heather J., Montefiori, David, Shen, Xiaoying, Dull, Peter, Plotkin, Stanley, Siber, George, Ambrosino, Donna

“…Correlates of protection for COVID-19 vaccines are urgently needed to license additional vaccines. We measured immune responses to four COVID-19 vaccines of…”
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