Search Results - "MONTANARO, Donatella"
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Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1
Published in Blood (09-05-2013)“…Autosomal dominant dehydrated hereditary stomatocytosis (DHSt) usually presents as a compensated hemolytic anemia with macrocytosis and abnormally shaped red…”
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MicroRNA-449a overexpression, reduced NOTCH1 signals and scarce goblet cells characterize the small intestine of celiac patients
Published in PloS one (15-12-2011)“…MiRNAs play a relevant role in regulating gene expression in a variety of physiological and pathological conditions including autoimmune disorders. MiRNAs are…”
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Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice
Published in Gene therapy (01-04-2019)“…Familial hypercholesterolemia (FH) is a genetic hyperlipidemia characterized by elevated concentrations of plasma LDL cholesterol. Statins are not always…”
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Detection of erbB2 copy number variations in plasma of patients with esophageal carcinoma
Published in BMC cancer (11-04-2011)“…Mortality is high in patients with esophageal carcinoma as tumors are rarely detected before the disease has progressed to an advanced stage. Here, we sought…”
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Meningococcal ABC-Type L-Glutamate Transporter GltT Is Necessary for the Development of Experimental Meningitis in Mice
Published in Infection and Immunity (01-09-2009)“…Experimental animal models of bacterial meningitis are useful to study the host-pathogen interactions occurring at the cerebral level and to analyze the…”
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Correction: MicroRNA-449a Overexpression, Reduced NOTCH1 Signals and Scarce Goblet Cells Characterize the Small Intestine of Celiac Patients
Published in PloS one (01-01-2012)“…The correct Figure 1 can be viewed here: thumbnail Download: * PPT PowerPoint slide * PNG larger image * TIFF original image Figures Citation: Capuano M,…”
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Thymidine kinase-mediated shut down of bone morphogenetic protein-4 expression allows regulated bone production
Published in Current gene therapy (01-06-2013)“…Bone morphogenetic Proteins (BMPs) are growth factors also involved in ossification and chondrogenesis that have generated interest for their efficiency in…”
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Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains
Published in Genomics (San Diego, Calif.) (01-06-2004)“…Nonmuscle myosin heavy chain II-A is responsible for MYH9-related disease, which is characterized by macrothrombocytopenia, granulocyte inclusions, deafness,…”
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Culture conditions allow selection of different mesenchymal progenitors from adult mouse bone marrow
Published in Tissue engineering. Part A (01-09-2009)“…The use of adult stem cells in tissue engineering approaches will benefit from the establishment of culture conditions that allow the expansion and maintenance…”
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The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome
Published in Pharmacological research (01-11-2020)“…[Display omitted] •LINC01087 is significantly downregulated in TNBCs and upregulated in the luminal BC subtypes.•Variation of the level of LINC01087 in the…”
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Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition
Published in Brain (London, England : 1878) (01-05-2018)“…The molecular events underlying dissemination of group 3 medulloblastoma remain elusive. Ferrucci et al. show that PRUNE1 overexpression enhances the canonical…”
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The T197A Knock-in Model of Cdkn1b Gene to Study the Effects of p27 Restoration In Vivo
Published in Molecular cancer therapeutics (01-02-2019)“…The CDK inhibitor, p27 , encoded by the gene can negatively modulate cell proliferation. The control of p27 activity during the cell cycle is regulated at…”
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The AKT1E17K Allele Promotes Breast Cancer in Mice
Published in Cancers (26-05-2022)“…The gain-of-function mutation in the pleckstrin homology domain of AKT1 (AKT1E17K) occurs in lung and breast cancer. Through the use of human cellular models…”
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HtrA1 loss is related to aggressive behavior parameters in sentinel node positive breast cancer
Published in Histology and histopathology (01-06-2015)“…HtrA1, a member of the High Temperature Requirement Factor A family of oxidative stress-response proteases seems to play a role as a tumor suppressor, being…”
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Characterization of Carbonic Anhydrase IX Interactome Reveals Proteins Assisting Its Nuclear Localization in Hypoxic Cells
Published in Journal of proteome research (04-01-2013)“…Carbonic anhydrase IX (CA IX) is a transmembrane protein affecting pH regulation, cell migration/invasion, and survival in hypoxic tumors. Although the…”
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Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibitio
Published in Brain (London, England : 1878) (2018)“…Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient…”
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Laparoscopic Adjustable Gastric Banding Reduces Subcutaneous Adipose Tissue and Blood Inflammation in Nondiabetic Morbidly Obese Individuals
Published in Obesity surgery (01-12-2014)“…Background Significant and sustained excess weight loss (EWL) appears to reduce the risk of obesity-related comorbidities (insulin resistance, hyperlipidemia,…”
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POZ-, AT-hook-, and Zinc Finger-containing Protein (PATZ) Interacts with Human Oncogene B Cell Lymphoma 6 (BCL6) and Is Required for Its Negative Autoregulation
Published in The Journal of biological chemistry (25-05-2012)“…The PATZ1 gene encoding a POZ/AT-hook/Kruppel zinc finger (PATZ) transcription factor, is considered a cancer-related gene because of its loss or misexpression…”
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