Synthetic Hydrated Aluminum Silicates as Oral Adsorbents of Potassium Ion

Synthetic Hydrated Aluminum Silicates as Oral Adsorbents of Potassium Ion

The adsorption of potassium ion by synthetic hydrated aluminum silicates (zeolites) was studied to examine the feasibility of application of zeolites as oral adsorbents for the treatment of hyper-kalemia. In vitro and in vivo adsorption studies indicated that one of the zeolites studied(ZPC-10A) had...

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Bibliographic Details
Published in:Chemical & pharmaceutical bulletin Vol. 34; no. 7; pp. 2973 - 2978
Main Authors: ISHIBASHI, MUMIO, YOSHIOKA, SUMIE, MONMA, JYUNKO, SUZUKI, YASUO, UCHIYAMA, MITSURU, WATANABE, TOSHIFUMI, TAKAI, SHINJI
Format: Journal Article
Language:English
Published: Tokyo The Pharmaceutical Society of Japan 1986
Maruzen
Japan Science and Technology Agency
Subjects:
Aluminum Silicates - pharmacology
Aluminum Silicates - toxicity
Animals
Biological and medical sciences
Dogs
Female
General and cellular metabolism. Vitamins
Intestinal Absorption - drug effects
Male
Medical sciences
oral adsorbent
Pharmacology. Drug treatments
Potassium - metabolism
Rats
Rats, Inbred Strains
Hyperkaliemia
In vivo
Treatment
Zeolite
Adsorbent
In vitro
Potassium Ions
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Summary:The adsorption of potassium ion by synthetic hydrated aluminum silicates (zeolites) was studied to examine the feasibility of application of zeolites as oral adsorbents for the treatment of hyper-kalemia. In vitro and in vivo adsorption studies indicated that one of the zeolites studied(ZPC-10A) had superior physical characteristics as a potassium ion adsorbent, as compared with conventional adsorbents (polystyrene sulfonates). An acute toxicity study also suggested that ZPC-10A is applicable as an oral adsorbent.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.34.2973