Search Results - "MONKS, B. G"

Divergent Response to LPS and Bacteria in CD14-Deficient Murine Macrophages by Moore, Kathryn J, Andersson, Lorna P, Ingalls, Robin R, Monks, Brian G, Li, Rui, Arnaout, M. Amin, Golenbock, Douglas T, Freeman, Mason W

“…Gram-negative bacteria and the LPS constituent of their outer membranes stimulate the release of inflammatory mediators believed to be responsible for the…”
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome by Espevik, Terje, Monks, Brian G, Golenbock, Douglas T, Latz, Eicke, Knetter, Cathrine F, Nilsen, Nadra J, Lien, Egil, Visintin, Alberto, Fitzgerald, Katherine A, Schoenemeyer, Annett

“…Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic…”
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Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction by Latz, Eicke, Visintin, Alberto, Lien, Egil, Fitzgerald, Kate A., Monks, Brian G., Kurt-Jones, Evelyn A., Golenbock, Douglas T., Espevik, Terje

“…Mammalian responses to LPS require the expression of Toll-like receptor 4 (TLR4), CD14, and MD-2. We expressed fluorescent TLR4 in cell lines and found that…”
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Lysines 128 and 132 Enable Lipopolysaccharide Binding to MD-2, Leading to Toll-like Receptor-4 Aggregation and Signal Transduction by Visintin, Alberto, Latz, Eicke, Monks, Brian G, Espevik, Terje, Golenbock, Douglas T

“…Three cell-surface proteins have been recognized as components of the mammalian signaling receptor for bacterial lipopolysaccharide (LPS): CD14, Toll-like…”
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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling by Schromm, A B, Lien, E, Henneke, P, Chow, J C, Yoshimura, A, Heine, H, Latz, E, Monks, B G, Schwartz, D A, Miyake, K, Golenbock, D T

“…Somatic cell mutagenesis is a powerful tool for characterizing receptor systems. We reported previously two complementation groups of mutant cell lines derived…”
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Involvement of Toll-like Receptor (TLR) 2 and TLR4 in Cell Activation by Mannuronic Acid Polymers by Flo, Trude H, Ryan, Liv, Latz, Eicke, Takeuchi, Osamu, Monks, Brian G, Lien, Egil, Halaas, Øyvind, Akira, Shizuo, Skjåk-Braek, Gudmund, Golenbock, Douglas T, Espevik, Terje

“…The alginate capsule produced by the human pathogen Pseudomonas aeruginosa is composed mainly of mannuronic acid polymers (poly-M) that have immunostimulating…”
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The functional importance of a cap site-proximal region of the human prointerleukin 1 beta gene is defined by viral protein trans-activation by HUNNINGHAKE, G. W, MONKS, B. G, GEIST, L. J, MONICK, M. M, MONROY, M. A, STINSKI, M. F, WEBB, A. C, DAYER, J.-M, AURON, P. E, FENTON, M. J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cutting Edge: Cells That Carry A Null Allele for Toll-Like Receptor 2 Are Capable of Responding to Endotoxin by Heine, Holger, Kirschning, Carsten J, Lien, Egil, Monks, Brian G, Rothe, Mike, Golenbock, Douglas T

“…Toll-like receptor (TLR) 2 and TLR4 have been implicated in the responses of cells to LPS (endotoxin). CD14-transfected Chinese hamster ovary (CHO)-K1…”
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The NF-beta A-binding element, not an overlapping NF-IL-6-binding element, is required for maximal IL-1 beta gene expression by Buras, JA, Monks, BG, Fenton, MJ

“…NF-beta A is a monocyte, neutrophil, and B cell-specific nuclear protein that is involved in regulation of the IL-1 beta gene. These studies further define the…”
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Dual effects of LPS antibodies on cellular uptake of LPS and LPS- induced proinflammatory functions by Pollack, M, Ohl, CA, Golenbock, DT, Di Padova, F, Wahl, LM, Koles, NL, Guelde, G, Monks, BG

“…Human phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor. This study tested the hypothesis that…”
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An upstream protein interacts with a distinct protein that binds to the cap site of the human interleukin 1 beta gene by Monks, B G, Martell, B A, Buras, J A, Fenton, M J

“…Interleukin 1 beta (IL-1 beta) is a proinflammatory cytokine that exhibits a wide variety of biological activities. Genomic sequences that mediate the…”
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Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact by Wurfel, M M, Monks, B G, Ingalls, R R, Dedrick, R L, Delude, R, Zhou, D, Lamping, N, Schumann, R R, Thieringer, R, Fenton, M J, Wright, S D, Golenbock, D

“…Gram-negative bacterial lipopolysaccharide (LPS) stimulates phagocytic leukocytes by interacting with the cell surface protein CD14. Cellular responses to LPS…”
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CD11/CD18 and CD14 Share a Common Lipid A Signaling Pathway by Ingalls, Robin R, Monks, Brian G, Savedra, Ricardo, Jr, Christ, William J, Delude, Russell L, Medvedev, Andrei E, Espevik, Terje, Golenbock, Douglas T

“…The activation of phagocytes by the lipid A moiety of LPS has been implicated in the pathogenesis of Gram-negative sepsis. While two LPS receptors, CD14 and…”
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Bacterial Lipopolysaccharide Induces Expression of the Stress Response Genes hop and H411 by Heine, Holger, Delude, Russell L., Monks, Brian G., Espevik, Terje, Golenbock, Douglas T.

“…CD14-transfected Chinese hamster ovary K1 fibroblasts (CHO/CD14) respond to lipopolysaccharide (LPS) by metabolizing arachidonic acid and with translocation of…”
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C4bp binding to porin mediates stable serum resistance of Neisseria gonorrhoeae by Ram, Sanjay, Cullinane, Meabh, Blom, Anna M, Gulati, Sunita, McQuillen, Daniel P, Boden, Ryan, Monks, Brian G, O'Connell, Catherine, Elkins, Christopher, Pangburn, Michael K, Dahlbäck, Björn, Rice, Peter A

“…Screening of 29 strains of Neisseria gonorrhoeae revealed that 16/21 serum resistant strains and 0/8 serum sensitive strains bound C4bp, suggesting that C4bp…”
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Membrane Expression of Soluble Endotoxin-binding Proteins Permits Lipopolysaccharide Signaling in Chinese Hamster Ovary Fibroblasts Independently of CD14 by Ingalls, Robin R., Monks, Brian G., Golenbock, Douglas T.

“…The activation of phagocytes by lipopolysaccharide (LPS) has been implicated in the pathogenesis of Gram-negative sepsis. Although the interaction between CD14…”
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Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae by Ram, S, Cullinane, M, Blom, A M, Gulati, S, McQuillen, D P, Monks, B G, O'Connell, C, Boden, R, Elkins, C, Pangburn, M K, Dahlbäck, B, Rice, P A

“…We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound…”
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The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I by Rothenfusser, Simon, Goutagny, Nadege, DiPerna, Gary, Gong, Mei, Monks, Brian G, Schoenemeyer, Annett, Yamamoto, Masahiro, Akira, Shizuo, Fitzgerald, Katherine A

“…The paramyxovirus Sendai (SV), is a well-established inducer of IFN-alphabeta gene expression. In this study we show that SV induces IFN-alphabeta gene…”
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MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4) by Visintin, Alberto, Halmen, Kristen A., Khan, Naseema, Monks, Brian G., Golenbock, Douglas T., Lien, Egil

“…The cell surface receptor complex formed by TLR4 and myeloid differentiation 2 (MD‐2) is engaged when cells are exposed to LPS. Recent studies suggested that…”
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The Myristoylation of TRIF-Related Adaptor Molecule Is Essential for Toll-Like Receptor 4 Signal Transduction by Rowe, Daniel C., McGettrick, Anne F., Latz, Eicke, Monks, Brian G., Gay, Nicholas J., Yamamoto, Masahiro, Akira, Shizuo, O'Neill, Luke A., Fitzgerald, Katherine A., Golenbock, Douglas T.

“…TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR)…”
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