Search Results - "MONIAUX, NICOLAS"

Targeting gut flora to prevent progression of hepatocellular carcinoma by Darnaud, Marion, Faivre, Jamila, Moniaux, Nicolas

“…Increased translocation of intestinal bacteria is a hallmark of chronic liver disease and contributes to hepatic inflammation and fibrosis. Here we tested the…”
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Regulation of mucin expression: Mechanistic aspects and implications for cancer and inflammatory diseases by Andrianifahanana, Mahefatiana, Moniaux, Nicolas, Batra, Surinder K.

“…Mucins are large multifunctional glycoproteins whose primary functions are to protect and lubricate the surfaces of epithelial tissues lining ducts and lumens…”
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Current status of mucins in the diagnosis and therapy of cancer by Rachagani, Satyanarayana, Torres, Maria P., Moniaux, Nicolas, Batra, Surinder K.

“…Mucins are the most abundant high molecular weight glycoproteins in mucus. Their nature and glycosylation content dictates the biochemical and biophysical…”
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Simultaneous activation and blockade of autophagy to fight hepatocellular carcinoma by Shalhoub, Hala, Gonzalez, Patrick, Dos Santos, Alexandre, Guillermet-Guibert, Julie, Moniaux, Nicolas, Dupont, Nicolas, Faivre, Jamila

“…ABSTRACTAutophagy is considered a target for cancer treatment, although few compounds manipulating this process have been added to the anticancer arsenal in…”
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MUC4 Mucin Potentiates Pancreatic Tumor Cell Proliferation, Survival, and Invasive Properties and Interferes with Its Interaction to Extracellular Matrix Proteins by Chaturvedi, Pallavi, Singh, Ajay P, Moniaux, Nicolas, Senapati, Shantibhushan, Chakraborty, Subhankar, Meza, Jane L, Batra, Surinder K

“…MUC4, a transmembrane mucin, is aberrantly expressed in pancreatic adenocarcinomas while remaining undetectable in the normal pancreas. Recent studies have…”
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Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis by SINGH, Ajay P, MONIAUX, Nicolas, CHAUHAN, Subhash C, MEZA, Jane L, BATRA, Surinder K

“…The MUC4 mucin is a high molecular weight membrane-bound glycoprotein. It is aberrantly expressed in pancreatic tumors and tumor cell lines with no detectable…”
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The Reg3α (HIP/PAP) Lectin Suppresses Extracellular Oxidative Stress in a Murine Model of Acute Liver Failure by Moniaux, Nicolas, Darnaud, Marion, Garbin, Kévin, Dos Santos, Alexandre, Guettier, Catherine, Samuel, Didier, Amouyal, Gilles, Amouyal, Paul, Bréchot, Christian, Faivre, Jamila

“…Acute liver failure (ALF) is a rapidly progressive heterogeneous illness with high mortality rate and no widely accessible cure. A promising drug candidate…”
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Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice by Gonzalez, Patrick, Dos Santos, Alexandre, Darnaud, Marion, Moniaux, Nicolas, Rapoud, Delphine, Lacoste, Claire, Nguyen, Tung-Son, Moullé, Valentine S., Deshayes, Alice, Amouyal, Gilles, Amouyal, Paul, Bréchot, Christian, Cruciani-Guglielmacci, Céline, Andréelli, Fabrizio, Magnan, Christophe, Faivre, Jamila

“…Innate immune mediators of pathogen clearance, including the secreted C-type lectins REG3 of the antimicrobial peptide (AMP) family, are known to be involved…”
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A Proof of Concept, Phase II Randomized European Trial, on the Efficacy of ALF-5755, a Novel Extracellular Matrix-Targeted Antioxidant in Patients with Acute Liver Diseases by Nalpas, Bertrand, Ichaï, Philippe, Jamot, Laure, Carbonell, Nicolas, Rudler, Marika, Mathurin, Philippe, Durand, François, Gerken, Guido, Manns, Michael, Trautwein, Christian, Larrey, Dominique, Radenne, Sylvie, Duvoux, Christophe, Leroy, Vincent, Bernuau, Jacques, Faivre, Jamila, Moniaux, Nicolas, Bréchot, Christian, Amouyal, Gilles, Amouyal, Paul, Samuel, Didier

“…No efficient medical treatment is available for severe acute hepatitis (SAH) except N-acetylcysteine for acetaminophen-induced acute liver failure. The human…”
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Human hepatocarcinoma‐intestine‐pancreas/pancreatitis‐associated protein cures fas‐induced acute liver failure in mice by attenuating free‐radical damage in injured livers by Moniaux, Nicolas, Song, Haiyan, Darnaud, Marion, Garbin, Kévin, Gigou, Michelle, Mitchell, Claudia, Samuel, Didier, Jamot, Laure, Amouyal, Paul, Amouyal, Gilles, Bréchot, Christian, Faivre, Jamila

“…Acute liver failure (ALF) is a rare syndrome with a difficult clinical management and a high mortality rate. During ALF, several molecular pathways governing…”
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Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer by Jain, Maneesh, Venkatraman, Ganesh, Moniaux, Nicolas, Kaur, Sukhwinder, Kumar, Sushil, Chakraborty, Subhankar, Varshney, Grish C, Batra, Surinder K

“…The MUC4 mucin is a high molecular weight, membrane-bound, and highly glycosylated protein. It is a multi-domain protein that is putatively cleaved into a…”
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The human RNA polymerase II-associated factor 1 (hPaf1): a new regulator of cell-cycle progression by Moniaux, Nicolas, Nemos, Christophe, Deb, Shonali, Zhu, Bing, Dornreiter, Irena, Hollingsworth, Michael A, Batra, Surinder K

“…The human PAF (hPAF) complex is part of the RNA polymerase II transcription apparatus and regulates multiple steps in gene expression. Further, the yeast…”
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Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas by Singh, Ajay P., Chauhan, Subhash C., Bafna, Sangeeta, Johansson, Sonny L., Smith, Lynette M., Moniaux, Nicolas, Lin, Ming-Fong, Batra, Surinder K.

“…BACKGROUND Mucins are considered important markers for early diagnosis and targeted therapy due to their aberrant and unique expression pattern during…”
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Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways by Andrianifahanana, Mahefatiana, Agrawal, Anshu, Singh, Ajay P, Moniaux, Nicolas, van Seuningen, Isabelle, Aubert, Jean-Pierre, Meza, Jane, Batra, Surinder K

“…The transmembrane mucin, MUC4, is aberrantly expressed with a high incidence in human pancreatic adenocarcinomas and plays an important role in the…”
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Human MUC4 Mucin cDNA and Its Variants in Pancreatic Carcinoma by Choudhury, Amit, Moniaux, Nicolas, Winpenny, John P., Hollingsworth, Michael A., Aubert, Jean-Pierre, Batra, Surinder K.

“…The human MUC4 gene is not expressed in normal pancreas; however, its dysregulation results in high levels of expression in pancreatic tumors. To investigate…”
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Characterization of Human Mucin MUC17 by Moniaux, Nicolas, Junker, Wade M., Singh, Ajay P., Jones, Andria M., Batra, Surinder K.

“…With increasing interest on mucins as diagnostic and therapeutic targets in cancers and other diseases, it is becoming imperative to characterize novel mucins…”
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Structural organization and classification of the human mucin genes by Moniaux, Nicolas

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Key role of sinusoidal endothelial cells in the triggering of liver regeneration by Moniaux, Nicolas, Faivre, Jamila

“…COMMENTARY ON: Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Ding BS, Nolan DJ, Butler JM, James D, Babazadeh…”
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A reengineered liver for transplantation by Moniaux, Nicolas, Faivre, Jamila

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Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis by Darnaud, Marion, Dos Santos, Alexandre, Gonzalez, Patrick, Augui, Sandrine, Lacoste, Claire, Desterke, Christophe, De Hertogh, Gert, Valentino, Emma, Braun, Emilie, Zheng, Jinzi, Boisgard, Raphael, Neut, Christel, Dubuquoy, Laurent, Chiappini, Franck, Samuel, Didier, Lepage, Patricia, Guerrieri, Francesca, Doré, Joel, Bréchot, Christian, Moniaux, Nicolas, Faivre, Jamila

“…Paneth cell dysfunction causes deficiencies in intestinal C-type lectins and antimicrobial peptides, which leads to dysbiosis of the intestinal microbiota,…”
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