Search Results - "MONIA, B. P"

Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance by Weismann, D, Erion, D. M, Ignatova-Todorava, I, Nagai, Y, Stark, R, Hsiao, J. J, Flannery, C, Birkenfeld, A. L, May, T, Kahn, M, Zhang, D, Yu, X. X, Murray, S. F, Bhanot, S, Monia, B. P, Cline, G. W, Shulman, G. I, Samuel, V. T

“…Aims/hypothesis Insulin action is purportedly modulated by Drosophila tribbles homologue 3 (TRIB3), which in vitro prevents thymoma viral proto-oncogene (AKT)…”
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Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression by MONIA, B. P, LESNIK, E. A, GONZALEZ, C, LIMA, W. F, MCGEE, D, GUINOSSO, C. J, KAWASAKI, A. M, COOK, P. D, FREIER, S. M

“…We have used a previously described 17-mer phosphorothioate (Monia, B.P., Johnston, J.F., Ecker, D. J., Zounes, M.A., Lima, W.F., and Freier, S.M. (1992) J…”
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Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer by MCPHILLIPS, F, MULLEN, P, MONIA, B. P, RITCHIE, A. A, DORR, F. A, SMYTH, J. F, LANGDON, S. P

“…c-Raf is an essential component of the extracellular related kinase (ERK) signal transduction pathway. Immunohistochemical staining indicated that c-Raf was…”
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Bcl-xL antisense oligonucleotides radiosensitise colon cancer cells by WACHECK, V, SELZER, E, GÜNSBERG, P, LUCAS, T, MEYER, H, THALLINGER, C, MONIA, B. P, JANSEN, B

“…Advanced colon cancer is a malignancy with poor response to various treatment modalities including ionising radiation (IR) and chemotherapy. Both IR and…”
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Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes by Crooke, S T, Lemonidis, K M, Neilson, L, Griffey, R, Lesnik, E A, Monia, B P

“…1. The effects of variations in substrates on the kinetic properties of Escherichia coli RNase H were studied using antisense oligonucleotides of various types…”
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Targeted delivery of antisense oligonucleotides to pancreatic β-cells by Ämmälä, C, Drury, 3rd, W J, Knerr, L, Ahlstedt, I, Stillemark-Billton, P, Wennberg-Huldt, C, Andersson, E-M, Valeur, E, Jansson-Löfmark, R, Janzén, D, Sundström, L, Meuller, J, Claesson, J, Andersson, P, Johansson, C, Lee, R G, Prakash, T P, Seth, P P, Monia, B P, Andersson, S

“…Antisense oligonucleotide (ASO) silencing of the expression of disease-associated genes is an attractive novel therapeutic approach, but treatments are limited…”
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Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo by BELENKOV, A. I, ALAKHOV, V. Y, KABANOV, A. V, VINOGRADOV, S. V, PANASCI, L. C, MONIA, B. P, CHOW, T. Y. K

“…In an effort to improve the efficacy of antisense delivery, we evaluated polyethyleneimine (PEI, 2 kDa) alone or grafted with nonionic amphiphilic block…”
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Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway by Schulte, Theodor W., Blagosklonny, Mikhail V., Romanova, Larissa, Mushinski, J. Frederic, Monia, Brett P., Johnston, Joseph F., Nguyen, Phuongmai, Trepel, Jane, Neckers, Leonard M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant by Finley, D, Sadis, S, Monia, B P, Boucher, P, Ecker, D J, Crooke, S T, Chau, V

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Antitumor activity of a C-raf antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted subcutaneously into nude mice by GEIGER, T, MÜLLER, M, MONIA, B. P, FABBRO, D

“…A 20-mer phosphorothioate oligodeoxynucleotide (ODN) directed against human C-raf kinase (CGP 69846A or ISIS 5132) was analyzed for its antitumor activity…”
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Coagulation factor XI as a novel target for antithrombotic treatment by LÖWENBERG, E. C., MEIJERS, J. C. M., MONIA, B. P., LEVI, M.

“…Coagulation factor (F)XI was first described as a member of the contact pathway of coagulation. However, the ‘classic’ theory of the extrinsic and intrinsic…”
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Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides by MONIA, B. P, JOHNSTON, J. F, ECKER, D. J, ZOUNES, M. A, LIMA, W. F, FREIER, S. M

“…A biological reporter gene assay was employed to determine the crucial parameters for maximizing selective targeting of a Ha-ras codon 12 point mutation…”
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c-raf-1 Depletion and Tumor Responses in Patients Treated with the c-raf-1 Antisense Oligodeoxynucleotide ISIS 5132 (CGP 69846A) by O'DWYER, P. J, STEVENSON, J. P, GALLAGHER, M, CASSELLA, A, VASILEVSKAYA, I, MONIA, B. P, HOIMLUND, J, DORR, F. A, YAO, K.-S

“…Abnormally regulated signaling through proliferative signal transduction pathways characterizes many of the common solid tumors. The best described of these…”
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PKC-ε Is Required for Mechano-sensitive Activation of ERK1/2 in Endothelial Cells by Traub, Oren, Monia, Brett P., Dean, Nicholas M., Berk, Bradford C.

“…Mechano-sensitive regulation of endothelial cells (EC) function by shear stress is critical for flow-induced vasodilation and gene expression. Previous studies…”
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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients by Nagata, Yoichi, Lan, Keng-Hsueh, Zhou, Xiaoyan, Tan, Ming, Esteva, Francisco J., Sahin, Aysegul A., Klos, Kristine S., Li, Ping, Monia, Brett P., Nguyen, Nina T., Hortobagyi, Gabriel N., Hung, Mien-Chie, Yu, Dihua

“…The ErbB2-targeting antibody, trastuzumab (Herceptin), has remarkable therapeutic efficacy in certain patients with ErbB2-overexpressing tumors. The overall…”
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Biophysical and antisense properties of oligodeoxynucleotides containing 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2′-deoxyadenosines by Balow, Guity, Mohan, Venkatraman, Lesnik, Elena A., Johnston, Joseph F., Monia, Brett P., Acevedo, Oscar L.

“…The synthesis of 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2′-deoxyadenosines is described. The nucleosides were synthesized, functionalized into the…”
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Implication of RNA structure on antisense oligonucleotide hybridization kinetics by Lima, Walt F, Monia, Brett P, Ecker, David J, Freier, Susan M

“…A 47-nucleotide transcript of the activated Ha-ras gene was prepared and determined, by enzymatic structure mapping, to form a stable hairpin structure. Six…”
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2‘-O-Aminopropyl Ribonucleotides:  A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides by Griffey, Richard H., Monia, Brett P., Cummins, Lendall L., Freier, Susan, Greig, Michael J., Guinosso, Charles J., Lesnik, Elena, Manalili, Sherilynn M., Mohan, Venkatraman, Owens, Steven, Ross, Bruce R., Sasmor, Henri, Wancewicz, Ed, Weiler, Kurt, Wheeler, Patrick D., Cook, P. Dan

“…Oligonucleotides containing 2‘-O-aminopropyl-substituted RNA have been synthesized. The 2‘-O-(aminopropyl)adenosine (APA), 2‘-O-(aminopropyl)cytidine (APC),…”
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Preclinical Evaluation of the Effects of a Novel Antisense Compound Targeting C-raf Kinase in Mice and Monkeys by Monteith, D. K., Geary, R. S., Leeds, J. M., Johnston, J., Monia, B. P., Levin, A. A.

“…CGP 69846A (ISIS 5132) is an antisense phosphorothioate oligodeoxynucleotide which targets human C-raf kinase and is currently being developed as an…”
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Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors by Altmann, K H, Fabbro, D, Dean, N M, Geiger, T, Monia, B P, Müller, M, Nicklin, P

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