Search Results - "MONDINI, Michele"

Radiotherapy–immunotherapy combinations – perspectives and challenges by Mondini, Michele, Levy, Antonin, Meziani, Lydia, Milliat, Fabien, Deutsch, Eric

“…Ionizing radiation has historically been used to treat cancer by killing tumour cells, in particular by inducing DNA damage. This view of radiotherapy (RT) as…”
Get full text

Macrophages in radiation injury: a new therapeutic target by Meziani, Lydia, Deutsch, Eric, Mondini, Michele

“…Radiotherapy can induce toxicity in healthy tissues such as radiation-induced fibrosis (RIF), and macrophages are proposed as new profibrogenic cells. In this…”
Get full text

Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade by Bergeron, Paul, Dos Santos, Morgane, Sitterle, Lisa, Tarlet, Georges, Lavigne, Jeremy, Liu, Winchygn, Gerbé de Thoré, Marine, Clémenson, Céline, Meziani, Lydia, Schott, Cathyanne, Mazzaschi, Giulia, Berthelot, Kevin, Benadjaoud, Mohamed Amine, Milliat, Fabien, Deutsch, Eric, Mondini, Michele

“…The efficacy and side effects of radiotherapy (RT) depend on parameters like dose and the volume of irradiated tissue. RT induces modulations of the tumor…”
Get full text

KRASG12C inhibition using MRTX1257: a novel radio-sensitizing partner by Laurent, Pierre-Antoine, Milic, Marina, Quevrin, Clément, Meziani, Lydia, Liu, Winchygn, Morel, Daphné, Signolle, Nicolas, Clémenson, Céline, Levy, Antonin, Mondini, Michele, Deutsch, Eric

“…Abstract Background KRAS activating mutations are considered the most frequent oncogenic drivers and are correlated with radio-resistance in multiple cancers…”
Get full text

An international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer by Levy, Antonin, Morel, Daphné, Texier, Matthieu, Sun, Roger, Durand-Labrunie, Jerome, Rodriguez-Ruiz, Maria E, Racadot, Severine, Supiot, Stéphane, Magné, Nicolas, Cyrille, Stacy, Louvel, Guillaume, Massard, Christophe, Verlingue, Loic, Bouquet, Fanny, Bustillos, Alberto, Bouarroudj, Lisa, Quevrin, Clément, Clémenson, Céline, Mondini, Michele, Meziani, Lydia, Tselikas, Lambros, Bahleda, Rastilav, Hollebecque, Antoine, Deutsch, Eric

“…Immuno-radiotherapy may improve outcomes for patients with advanced solid tumors, although optimized combination modalities remain unclear. Here, we report the…”
Get full text

The MET/AXL/FGFR Inhibitor S49076 Impairs Aurora B Activity and Improves the Antitumor Efficacy of Radiotherapy by Clémenson, Céline, Chargari, Cyrus, Liu, Winchygn, Mondini, Michele, Ferté, Charles, Burbridge, Mike F, Cattan, Valérie, Jacquet-Bescond, Anne, Deutsch, Eric

“…Several therapeutic agents targeting HGF/MET signaling are under clinical development as single agents or in combination, notably with anti-EGFR therapies in…”
Get full text

Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues by Solier, Stéphanie, Mondini, Michele, Meziani, Lydia, Jacquel, Arnaud, Lacout, Catherine, Berghe, Tom Vanden, Julé, Yvon, Martinou, Jean-Claude, Pierron, Gérard, Rivière, Julie, Deloger, Marc, Dupuy, Corinne, Slama-Schwok, Anny, Droin, Nathalie, Vandenabeele, Peter, Auberger, Patrick, Deutsch, Eric, El-Benna, Jamel, Dang, Pham My-Chan, Solary, Eric

“…Circulating monocytes are recruited in damaged tissues to generate macrophages that modulate disease progression. Colony-stimulating factor-1 (CSF-1) promotes…”
Get full text

TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy by Hamon, Pauline, Gerbé De Thoré, Marine, Classe, Marion, Signolle, Nicolas, Liu, Winchygn, Bawa, Olivia, Meziani, Lydia, Clémenson, Céline, Milliat, Fabien, Deutsch, Eric, Mondini, Michele

“…BackgroundTransforming growth factor-beta (TGFβ) can limit the efficacy of cancer treatments, including radiotherapy (RT), by inducing an immunosuppressive…”
Get full text

Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation by Meziani, Lydia, Gerbé de Thoré, Marine, Clémenson, Céline, Liu, Winchygn, Laurent, Pierre-Antoine, Mondini, Michele, Vozenin, Marie-Catherine, Deutsch, Eric

“…BackgroundIrradiation (IR) and immune checkpoint inhibitor (ICI) combination is a promising treatment modality. However, local and distance treatment failure…”
Get full text

Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference by Gregucci, Fabiana, Spada, Sheila, Barcellos-Hoff, Mary Helen, Bhardwaj, Nina, Chan Wah Hak, Charleen, Fiorentino, Alba, Guha, Chandan, Guzman, Monica L., Harrington, Kevin, Herrera, Fernanda G., Honeychurch, Jamie, Hong, Theodore, Iturri, Lorea, Jaffee, Elisabeth, Karam, Sana D., Knott, Simon R.V., Koumenis, Constantinos, Lyden, David, Marciscano, Ariel E., Melcher, Alan, Mondini, Michele, Mondino, Anna, Morris, Zachary S., Pitroda, Sean, Quezada, Sergio A., Santambrogio, Laura, Shiao, Stephen, Stagg, John, Telarovic, Irma, Timmerman, Robert, Vozenin, Marie-Catherine, Weichselbaum, Ralph, Welsh, James, Wilkins, Anna, Xu, Chris, Zappasodi, Roberta, Zou, Weiping, Bobard, Alexandre, Demaria, Sandra, Galluzzi, Lorenzo, Deutsch, Eric, Formenti, Silvia C.

“…Focal radiation therapy (RT) has attracted considerable attention as a combinatorial partner for immunotherapy (IT), largely reflecting a well-defined,…”
Get full text

Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages by Meziani, Lydia, Gerbé de Thoré, Marine, Hamon, Pauline, Bockel, Sophie, Andrade Louzada, Ruy, Clemenson, Céline, Corre, Raphaël, Liu, Wincgygn, Dupuy, Corinne, Mondini, Michele, Deutsch, Eric

“…Background Macrophages play pivotal roles in tumor progression and the response to anticancer therapies, including radiotherapy (RT). Dual oxidase (DUOX) 1 is…”
Get full text

Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesis by Mazibrada, Jasenka, Rittà, Massimo, Mondini, Michele, De Andrea, Marco, Azzimonti, Barbara, Borgogna, Cinzia, Ciotti, Marco, Orlando, Augusto, Surico, Nicola, Chiusa, Luigi, Landolfo, Santo, Gariglio, Marisa

“…Abstract Objective. The primary aim of this study was to investigate the role of angiogenesis and inflammatory cell response in cervical carcinogenesis…”
Get full text

Metabolic features of cancer cells impact immunosurveillance by Joseph, Adrien, Juncheng, Pan, Mondini, Michele, Labaied, Nizar, Loi, Mauro, Adam, Julien, Lafarge, Antoine, Astesana, Valentina, Obrist, Florine, Klein, Christophe, Bloy, Norma, Stoll, Gautier, Signolle, Nicolas, Genestie, Catherine, Damotte, Diane, Alifano, Marco, Leary, Alexandra, Pautier, Patricia, Morice, Philippe, Gouy, Sebastien, Deutsch, Eric, Chargari, Cyrus, Dieu-Nosjean, Marie-Caroline, Cremer, Isabelle, Michels, Judith, Kroemer, Guido, Castedo, Maria

“…BackgroundTumors rewire their metabolism to achieve robust anabolism and resistance against therapeutic interventions like cisplatin treatment. For example, a…”
Get full text

The multifaceted interferon-inducible p200 family proteins: from cell biology to human pathology by Gariglio, Marisa, Mondini, Michele, De Andrea, Marco, Landolfo, Santo

“…The interferon-inducible p200 family proteins consist of a group of homologous human and mouse proteins that have an N-terminal Pyrin domain and 1 or 2…”
Get more information

The interferon-inducible HIN-200 gene family in apoptosis and inflammation: Implication for autoimmunity by Mondini, Michele, Costa, Silvia, Sponza, Simone, Gugliesi, Francesca, Gariglio, Marisa, Landolfo, Santo

“…The Ifi-200/HIN-200 gene family encodes highly homologous human (IFI16, myeloid cell nuclear differentiation antigen, absent in melanoma 2, and IFIX) and…”
Get full text

Role of the Interferon-Inducible Gene IFI16 in the Etiopathogenesis of Systemic Autoimmune Disorders by MONDINI, MICHELE, VIDALI, MATTEO, AIRÒ, PAOLO, DE ANDREA, MARCO, RIBOLDI, PIERSANDRO, MERONI, PIER LUIGI, GARIGLIO, MARISA, LANDOLFO, SANTO

“…:  Interferons (IFNs) are now known to exert a multitude of immunological functions on both the innate and adaptive immunity. Given their pleiotropic effects…”
Get full text

A Novel Role of the Interferon-inducible Protein IFI16 as Inducer of Proinflammatory Molecules in Endothelial Cells by Caposio, Patrizia, Gugliesi, Francesca, Zannetti, Claudia, Sponza, Simone, Mondini, Michele, Medico, Enzo, Hiscott, John, Young, Howard A., Gribaudo, Giorgio, Gariglio, Marisa, Landolfo, Santo

“…The human IFI16 gene is an interferon-inducible gene implicated in the regulation of endothelial cell proliferation and tube morphogenesis. Immunohistochemical…”
Get full text

Keratinocyte-Specific Stat3 Heterozygosity Impairs Development of Skin Tumors in Human Papillomavirus 8 Transgenic Mice by DE ANDREA, Marco, RITTA, Massimo, PFISTER, Herbert, LANDOLFO, Santo, GARIGLIO, Marisa, LANDINI, Manuela M, BORGOGNA, Cinzia, MONDINI, Michele, KERN, Florian, EHRENREITER, Karin, BACCARINI, Manuela, PAOLO MARCUZZI, Gian, SMOLA, Sigrun

“…Human papillomaviruses (HPV) of the genus β are thought to play a role in human skin cancers, but this has been difficult to establish using epidemiologic…”
Get full text

(Chemo)Radiotherapy-Immunotherapy Combinations: Time to Get Tailored? by Mondini, Michele, Deutsch, Eric

“…Chemoradiotherapy is considered an immunogenic anticancer treatment. Data obtained during the course of chemoradiotherapy treatment of patients with cervical…”
Get full text

Dialect Effects in Speech Perception: The Role of Vowel Duration in Parisian French and Swiss French by Miller, Joanne L., Mondini, Michèle, Grosjean, François, Dommergues, Jean-Yves

“…The current experiments examined how native Parisian French and native Swiss French listeners use vowel duration in perceiving the /ɔ/-/o/ contrast. In both…”
Get full text