Search Results - "MONAHAN, P."

Gene therapy in an era of emerging treatment options for hemophilia B by Monahan, P. E.

“…Summary Factor IX deficiency (hemophilia B) is less common than factor VIII deficiency (hemophilia A), and innovations in therapy for hemophilia B have…”
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Psychosocial Impact of COVID-19 Nursing Home Restrictions on Visitors of Residents With Cognitive Impairment: A Cross-Sectional Study as Part of the Engaging Remotely in Care (ERiC) Project by O'Caoimh, Rónán, O'Donovan, Mark R., Monahan, Margaret P., Dalton O'Connor, Caroline, Buckley, Catherine, Kilty, Caroline, Fitzgerald, Serena, Hartigan, Irene, Cornally, Nicola

“…Background: COVID-19 has disproportionately affected older people. Visiting restrictions introduced since the start of the pandemic in residential care…”
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Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo by MCCARTY, D. M, FU, H, MONAHAN, P. E, TOULSON, C. E, NAIK, P, SAMULSKI, R. J

“…An important limitation of recombinant adeno-associated virus (rAAV) vector efficiency is the requirement of hostcell-mediated synthesis of double-stranded DNA…”
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Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia by Li, C, Narkbunnam, N, Samulski, R J, Asokan, A, Hu, G, Jacobson, L J, Manco-Johnson, M J, Monahan, P E

“…Recombinant adeno-associated virus (rAAV) is a promising gene delivery vector and has recently been used in patients with hemophilia. One limitation of AAV…”
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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis by MCCARTY, D. M, MONAHAN, P. E, SAMULSKI, R. J

“…Adeno-associated virus (AAV) vectors package single-stranded genomes and require host-cell synthesis of the complementary strand for transduction. However,…”
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AAV vectors : is clinical success on the horizon? by MONAHAN, P. E, SAMULSKI, R. J

“…Potential applications and impact of the adeno-associated virus (AAV) as a gene transfer vector have expanded rapidly in the last decade. Recent advances in…”
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IL‐6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding‐induced arthropathy in hemophilia by Narkbunnam, N., Sun, J., Hu, G., Lin, F.‐C., Bateman, T. A., Mihara, M., Monahan, P. E.

“…Summary Background The most common morbidity that results from hemophilia is bleeding‐induced hemophilic arthropathy (HA), which once established may not be…”
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Prevalent inhibitors in haemophilia B subjects enrolled in the Universal Data Collection database by Puetz, J., Soucie, J. M., Kempton, C. L., Monahan, P. E.

“…Summary Several risk factors for inhibitors have recently been described for haemophilia A. It has been assumed that similar risk factors are also relevant for…”
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Evaluation of risks related to the use of adeno-associated virus-based vectors by Tenenbaum, L, Lehtonen, E, Monahan, P E

“…Recombinant AAV efficacy has been demonstrated in numerous gene therapy preclinical studies. As this vector is increasingly applied to human clinical trials,…”
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The effects of hypogonadism on quality of life in survivors of germ cell tumors treated with surgery alone versus surgery plus platinum-based chemotherapy by Khanal, N., Ahmed, S. S., Kalra, M., Miller, T. J., Brames, M. J., Stump, T. E., Monahan, P., Hanna, N. H., Einhorn, Lawrence H.

“…Background It is important to assess the prevalence of hypogonadism and to identify the correlation between hypogonadism and cancer treatment with quality of…”
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Inhibitor recurrence after immune tolerance induction: a multicenter retrospective cohort study by Antun, A., Monahan, P. E., Manco‐Johnson, M. J., Callaghan, M. U., Kanin, M., Knoll, C., Carpenter, S. L., Davis, J. A., Guerrera, M. F., Kruse‐Jarres, R., Ragni, M. V., Witmer, C., McCracken, C. E., Kempton, C. L.

“…Summary Background Immune tolerance induction (ITI) in patients with congenital hemophilia A is successful in up to 70%. Although there is growing…”
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Long-term phenotypic correction in factor IX knockout mice by using phiC31 integrase-mediated gene therapy by Keravala, A, Chavez, C L, Hu, G, Woodard, L E, Monahan, P E, Calos, M P

“…Hemophilia B, a hereditary bleeding disorder caused by a deficiency of coagulation factor IX (FIX), is an excellent candidate for gene therapy. However, to…”
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The expanding menagerie: animal models of hemophilia A by MONAHAN, P. E.

“…See also Booth CJ, Brooks MB, Rockwell S, Murphy JW, Rinder HM, Zelterman D, Paidas MJ, Compton SR, Marks PW. WAG‐F8m1Ycb rats harboring a factor VIII gene…”
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Ampiginous choroiditis following quadrivalent human papilloma virus vaccine by Khalifa, Y M, Monahan, P M, Acharya, N R

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Recombinant porcine factor VIII for high‐risk surgery in paediatric congenital haemophilia A with high‐titre inhibitor by Croteau, S. E., Abajas, Y. L., Wolberg, A. S., Nielsen, B. I., Marx, G. R., Baird, C. W., Neufeld, E. J., Monahan, P. E.

“…Introduction High‐titre factor VIII (FVIII) inhibitors complicate peri‐operative haemostasis. Recombinant porcine FVIII (r‐pFVIII) may provide an alternative…”
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Confirmatory test of two factors and four subtypes of bipolar disorder based on lifetime psychiatric co-morbidity by Monahan, P O, Stump, T, Coryell, W H, Harezlak, J, Marcoulides, G A, Liu, H, Steeger, C M, Mitchell, P B, Wilcox, H C, Hulvershorn, L A, Glowinski, A L, Iyer-Eimerbrink, P A, McInnis, M, Nurnberger, J I

“…The first aim was to use confirmatory factor analysis (CFA) to test a hypothesis that two factors (internalizing and externalizing) account for lifetime…”
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Adaptation of family caregivers during the acute phase of adult BMT by Fife, B L, Monahan, P O, Abonour, R, Wood, L L, Stump, T E

“…This study examined the course of adaptation as indicated by the level of emotional distress for family caregivers of adult BM recipients across the acute…”
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Joint bleeding in factor VIII deficient mice causes an acute loss of trabecular bone and calcification of joint soft tissues which is prevented with aggressive factor replacement by Lau, A. G., Sun, J., Hannah, W. B., Livingston, E. W., Heymann, D., Bateman, T. A., Monahan, P. E.

“…Summary While chronic degenerative arthropathy is the main morbidity of haemophilia, a very high prevalence of low bone density is also seen in men and boys…”
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Familial deficiency of vitamin K-dependent clotting factors by WESTON, B. W., MONAHAN, P. E.

“…Combined deficiency of vitamin K‐dependent clotting factors II, VII, IX and X (and proteins C, S, and Z) is usually an acquired clinical problem, often…”
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Abnormal hemostasis in a knock‐in mouse carrying a variant of factor IX with impaired binding to collagen type IV by GUI, T., REHEMAN, A., NI, H., GROSS, P. L., YIN, F., MONROE, D., MONAHAN, P. E., STAFFORD, D. W.

“…Background: Factor IX binds to collagen type IV, but this binding has no known consequence. Objectives: To determine the effect of reduced binding of FIX to…”
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