Search Results - "MOLOGNI, Luca"

Inhibitors of the anaplastic lymphoma kinase by Mologni, Luca

“…Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase normally expressed in the developing nervous tissue. Genetic alterations of ALK are associated…”
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SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome by Banfi, Federica, Rubio, Alicia, Zaghi, Mattia, Massimino, Luca, Fagnocchi, Giulia, Bellini, Edoardo, Luoni, Mirko, Cancellieri, Cinzia, Bagliani, Anna, Di Resta, Chiara, Maffezzini, Camilla, Ianielli, Angelo, Ferrari, Maurizio, Piazza, Rocco, Mologni, Luca, Broccoli, Vania, Sessa, Alessandro

“…The investigation of genetic forms of juvenile neurodegeneration could shed light on the causative mechanisms of neuronal loss. Schinzel-Giedion syndrome (SGS)…”
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Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR by Foschi, Francesca, Tinivella, Annachiara, Crippa, Valentina, Pinzi, Luca, Mologni, Luca, Passarella, Daniele, Rastelli, Giulio

“…EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The…”
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Recurrent SETBP1 mutations in atypical chronic myeloid leukemia by Piazza, Rocco, Valletta, Simona, Winkelmann, Nils, Redaelli, Sara, Spinelli, Roberta, Pirola, Alessandra, Antolini, Laura, Mologni, Luca, Donadoni, Carla, Papaemmanuil, Elli, Schnittger, Susanne, Kim, Dong-Wook, Boultwood, Jacqueline, Rossi, Fabio, Gaipa, Giuseppe, De Martini, Greta P, di Celle, Paola Francia, Jang, Hyun Gyung, Fantin, Valeria, Bignell, Graham R, Magistroni, Vera, Haferlach, Torsten, Pogliani, Enrico Maria, Campbell, Peter J, Chase, Andrew J, Tapper, William J, Cross, Nicholas C P, Gambacorti-Passerini, Carlo

“…Carlo Gambacorti-Passerini and colleagues identify recurrent SETBP1 mutations in atypical chronic myeloid leukemia. The mutations, which cluster in a small…”
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Crizotinib in Advanced, Chemoresistant Anaplastic Lymphoma Kinase―Positive Lymphoma Patients by PASSERINI, Carlo Gambacorti, FARINA, Francesca, MUSSOLIN, Lara, DEEREN, Dries, KING, Michael H, STEURER, Michael, ORDEMANN, Rainer, COHEN, Amos M, GRUBE, Matthias, BERNARD, Lea, CHIRIANO, Gianpaolo, ANTOLINI, Laura, STASIA, Alessandra, PIAZZA, Rocco, REDAELLI, Sara, CECCON, Monica, MOLOGNI, Luca, MESSA, Cristina, GUERRA, Luca, GIUDICI, Giovanni, SALA, Elena

“…Anaplastic lymphoma kinase (ALK)-positive lymphomas respond to chemotherapy, but relapses, which bear a poor prognosis, occur. Crizotinib inhibits ALK in vitro…”
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STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma by Lobello, Cosimo, Tichy, Boris, Bystry, Vojtech, Radova, Lenka, Filip, Daniel, Mraz, Marek, Montes-Mojarro, Ivonne-Aidee, Prokoph, Nina, Larose, Hugo, Liang, Huan-Chang, Sharma, Geeta G., Mologni, Luca, Belada, David, Kamaradova, Katerina, Fend, Falko, Gambacorti-Passerini, Carlo, Merkel, Olaf, Turner, Suzanne D., Janikova, Andrea, Pospisilova, Sarka

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Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma by Karaca Atabay, Elif, Mecca, Carmen, Wang, Qi, Ambrogio, Chiara, Mota, Ines, Prokoph, Nina, Mura, Giulia, Martinengo, Cinzia, Patrucco, Enrico, Leonardi, Giulia, Hossa, Jessica, Pich, Achille, Mologni, Luca, Gambacorti-Passerini, Carlo, Brugières, Laurence, Geoerger, Birgit, Turner, Suzanne D., Voena, Claudia, Cheong, Taek-Chin, Chiarle, Roberto

“…Anaplastic large cell lymphomas (ALCLs) frequently carry oncogenic fusions involving the anaplastic lymphoma kinase (ALK) gene. Targeting ALK using tyrosine…”
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Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors by Ceccon, Monica, Mologni, Luca, Bisson, William, Scapozza, Leonardo, Gambacorti-Passerini, Carlo

“…The dual ALK/MET inhibitor crizotinib was recently approved for the treatment of metastatic and late-stage ALK+ NSCLC, and is currently in clinical trial for…”
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Evolutionary signatures of human cancers revealed via genomic analysis of over 35,000 patients by Fontana, Diletta, Crespiatico, Ilaria, Crippa, Valentina, Malighetti, Federica, Villa, Matteo, Angaroni, Fabrizio, De Sano, Luca, Aroldi, Andrea, Antoniotti, Marco, Caravagna, Giulio, Piazza, Rocco, Graudenzi, Alex, Mologni, Luca, Ramazzotti, Daniele

“…Recurring sequences of genomic alterations occurring across patients can highlight repeated evolutionary processes with significant implications for predicting…”
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Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target by Larose, Hugo, Prokoph, Nina, Matthews, Jamie D, Schlederer, Michaela, Högler, Sandra, Alsulami, Ali F, Ducray, Stephen P, Nuglozeh, Edem, Fazaludeen, Feroze M S, Elmouna, Ahmed, Ceccon, Monica, Mologni, Luca, Gambacorti-Passerini, Carlo, Hoefler, Gerald, Lobello, Cosimo, Pospisilova, Sarka, Janikova, Andrea, Woessmann, Wilhelm, Damm-Welk, Christine, Zimmermann, Martin, Federova, Alina, Malone, Andrea, Smith, Owen, Wasik, Mariusz, Inghirami, Giorgio, Lamant, Laurence, Blundell, Tom L, Klapper, Wolfram, Merkel, Olaf, Burke, Amos G A, Mian, Shahid, Ashankyty, Ibraheem, Kenner, Lukas, Turner, Suzanne D

“…Patients diagnosed with Anaplastic Large Cell Lymphoma (ALCL) are still treated with toxic multi-agent chemotherapy and as many as 25-50% of patients relapse…”
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Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells by Mologni, Luca, Brussolo, Stefania, Ceccon, Monica, Gambacorti-Passerini, Carlo

“…Activation of Wnt signalling due to inability to degrade β-catenin is found in >85% of colorectal cancers. Approximately half of colon cancers express a…”
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TWIST1 Upregulation Is a Potential Target for Reversing Resistance to the CDK4/6 Inhibitor in Metastatic Luminal Breast Cancer Cells by Cordani, Nicoletta, Mologni, Luca, Piazza, Rocco, Tettamanti, Pietro, Cogliati, Viola, Mauri, Mario, Villa, Matteo, Malighetti, Federica, Di Bella, Camillo, Jaconi, Marta, Cerrito, Maria Grazia, Cavaletti, Guido, Lavitrano, Marialuisa, Cazzaniga, Marina Elena

“…Cyclin-dependent kinase (CDK) 4/6 inhibitors have significantly improved progression-free survival in hormone-receptor-positive (HR+),…”
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Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition by Zaghi, Mattia, Banfi, Federica, Massimino, Luca, Volpin, Monica, Bellini, Edoardo, Brusco, Simone, Merelli, Ivan, Barone, Cristiana, Bruni, Michela, Bossini, Linda, Lamparelli, Luigi Antonio, Pintado, Laura, D’Aliberti, Deborah, Spinelli, Silvia, Mologni, Luca, Colasante, Gaia, Ungaro, Federica, Cioni, Jean-Michel, Azzoni, Emanuele, Piazza, Rocco, Montini, Eugenio, Broccoli, Vania, Sessa, Alessandro

“…Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering with the net…”
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Activity of second‐generation ALK inhibitors against crizotinib‐resistant mutants in an NPM‐ALK model compared to EML4‐ALK by Fontana, Diletta, Ceccon, Monica, Gambacorti‐Passerini, Carlo, Mologni, Luca

“…Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor involved in both solid and hematological tumors. About 80% of ALK‐positive anaplastic large‐cell…”
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Conditioned Medium of Mesenchymal Stromal Cells Loaded with Paclitaxel Is Effective in Preclinical Models of Triple-Negative Breast Cancer (TNBC) by Cordani, Nicoletta, Lisini, Daniela, Coccè, Valentina, Paglia, Giuseppe, Meanti, Ramona, Cerrito, Maria Grazia, Tettamanti, Pietro, Bonaffini, Luca, Paino, Francesca, Alessandri, Giulio, Marcianti, Angela, Giannì, Aldo, Villa, Chiara, Mauri, Mario, Mologni, Luca, Torsello, Antonio, Pessina, Augusto, Cazzaniga, Marina Elena

“…Triple-negative breast cancer (TNBC) is a very aggressive disease even in its early stages and is characterized by a severe prognosis. Neoadjuvant chemotherapy…”
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Three novel patient-derived BCR/ABL mutants show different sensitivity to second and third generation tyrosine kinase inhibitors by Redaelli, Sara, Mologni, Luca, Rostagno, Roberta, Piazza, Rocco, Magistroni, Vera, Ceccon, Monica, Viltadi, Michela, Flynn, Daniel, Gambacorti-Passerini, Carlo

“…BCR/ABL (Breakpoint Cluster Region protein/Abelson tyrosine-protein kinase 1) kinase domain (KD) mutations represent the most frequently described mechanism of…”
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Somatic mutations identified at diagnosis by exome sequencing can predict response to imatinib in chronic phase chronic myeloid leukemia (CML) patients by Mologni, Luca, Piazza, Rocco, Khandelwal, Praveen, Pirola, Alessandra, Gambacorti-Passerini, Carlo

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BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells by Sala, Elisa, Mologni, Luca, Truffa, Silvia, Gaetano, Carlo, Bollag, Gideon E, Gambacorti-Passerini, Carlo

“…BRAF-activating mutations have been reported in several types of cancer, including melanoma (∼70% of cases), thyroid (30-70%), ovarian (15-30%), and colorectal…”
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Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells by Mologni, Luca, Costanza, Mariantonia, Sharma, Geeta Geeta, Viltadi, Michela, Massimino, Luca, Citterio, Stefania, Purgante, Stefania, Raman, Hima, Pirola, Alessandra, Zucchetti, Massimo, Piazza, Rocco, Gambacorti-Passerini, Carlo

“…BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell…”
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Epigenetic Silencing of the Proapoptotic Gene BIM in Anaplastic Large Cell Lymphoma through an MeCP2/SIN3a Deacetylating Complex by Piazza, Rocco, Magistroni, Vera, Mogavero, Angela, Andreoni, Federica, Ambrogio, Chiara, Chiarle, Roberto, Mologni, Luca, Bachmann, Petra S, Lock, Richard B, Collini, Paola, Pelosi, Giuseppe, Gambacorti-Passerini, Carlo

“…Abstract BIM is a proapoptotic member of the Bcl-2 family. Here, we investigated the epigenetic status of the BIM locus in NPM/ALK+ anaplastic large cell…”
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