Search Results - "MOLNAR, Kathleen S"

Signal Transduction in Histidine Kinases: Insights from New Structures by Bhate, Manasi P., Molnar, Kathleen S., Goulian, Mark, DeGrado, William F.

“…Histidine kinases (HKs) are major players in bacterial signaling. There has been an explosion of new HK crystal structures in the last 5 years. We globally…”
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Cys-Scanning Disulfide Crosslinking and Bayesian Modeling Probe the Transmembrane Signaling Mechanism of the Histidine Kinase, PhoQ by Molnar, Kathleen S., Bonomi, Massimiliano, Pellarin, Riccardo, Clinthorne, Graham D., Gonzalez, Gabriel, Goldberg, Shalom D., Goulian, Mark, Sali, Andrej, DeGrado, William F.

“…Bacteria transduce signals across the membrane using two-component systems (TCSs), consisting of a membrane-spanning sensor histidine kinase and a cytoplasmic…”
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Analysis of amyloid-like secondary structure in the Cryab-R120G knock-in mouse model of hereditary cataracts by two-dimensional infrared spectroscopy by Alperstein, Ariel M, Molnar, Kathleen S, Dicke, Sidney S, Farrell, Kieran M, Makley, Leah N, Zanni, Martin T, Andley, Usha P

“…αB-crystallin is a small heat shock protein that forms a heterooligomeric complex with αA-crystallin in the ocular lens. It is also widely distributed in…”
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Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ by Mensa, Bruk, Polizzi, Nicholas F, Molnar, Kathleen S, Natale, Andrew M, Lemmin, Thomas, DeGrado, William F

“…Transmembrane signaling proteins couple extracytosolic sensors to cytosolic effectors. Here, we examine how binding of Mg to the sensor domain of an two…”
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Specificity of immobilized porcine pepsin in H/D exchange compatible conditions by Hamuro, Yoshitomo, Coales, Stephen J., Molnar, Kathleen S., Tuske, Steven J., Morrow, Jeffrey A.

“…Statistical analysis of data from 39 proteins (13 766 amino acid residues) digested with immobilized porcine pepsin under conditions compatible with…”
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Local Conformational Stability of HIV-1 gp120 in Unliganded and CD4-Bound States as Defined by Amide Hydrogen/Deuterium Exchange by KONG, Leopold, HUANG, Chih-Chin, COALES, Stephen J, MOLNAR, Kathleen S, SKINNER, Jeff, HAMURO, Yoshitomo, KWONG, Peter D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts by Molnar, Kathleen S, Dunyak, Bryan M, Su, Bonnie, Izrayelit, Yevgeniy, McGlasson-Naumann, Brittney, Hamilton, Paul D, Qian, Mingxing, Covey, Douglas F, Gestwicki, Jason E, Makley, Leah N, Andley, Usha P

“…We previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand…”
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A Common Property of Amyotrophic Lateral Sclerosis-associated Variants by Molnar, Kathleen S., Karabacak, N.Murat, Johnson, Joshua L., Wang, Qi, Tiwari, Ashutosh, Hayward, Lawrence J., Coales, Stephen J., Hamuro, Yoshitomo, Agar, Jeffrey N.

“…At least 119 mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis by an unidentified toxic gain of…”
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Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction by Fong, Karen P., Molnar, Kathleen S., Agard, Nicholas, Litvinov, Rustem I., Kim, Oleg V., Wells, James A., Weisel, John W., DeGrado, William F., Bennett, Joel S.

“…Blood clot contraction is driven by traction forces generated by the platelet cytoskeleton that are transmitted to fibrin fibers via the integrin αIIbβ3. Here…”
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Exploring N‑Arylsulfonyl‑l‑proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors by Reed, Nilgun Isik, Tang, You-Zhi, McIntosh, Joel, Wu, Yibing, Molnar, Kathleen S, Civitavecchia, Annafelicia, Sheppard, Dean, DeGrado, William F, Jo, Hyunil

“…One small molecule inhibitor of αvβ1 integrin, c8, shows antifibrotic effects in multiple in vivo mouse models. Here we synthesized c8 analogues and…”
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Common Property of Amyotrophic Lateral Sclerosis-associated Variants: DESTABILIZATION OF THE COPPER/ZINC SUPEROXIDE DISMUTASE ELECTROSTATIC LOOP by Molnar, Kathleen S, Karabacak, N. Murat, Johnson, Joshua L, Wang, Qi, Tiwari, Ashutosh, Hayward, Lawrence J, Coales, Stephen J, Hamuro, Yoshitomo, Agar, Jeffrey N

“…At least 119 mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis by an unidentified toxic gain of…”
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Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator by Luo, Lusong, Carson, Jeffrey D, Molnar, Kathleen S, Tuske, Steven J, Coales, Stephen J, Hamuro, Yoshitomo, Sung, Chiu-mei, Sudakin, Valery, Auger, Kurt R, Dhanak, Dashyant, Jackson, Jeffrey R, Huang, Pearl S, Tummino, Peter J, Copeland, Robert A

“…Human kinesin spindle protein (KSP)/hsEg5, a member of the kinesin-5 family, is essential for mitotic spindle assembly in dividing human cells and is required…”
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Hydrogen-deuterium exchange mass spectrometry for investigation of backbone dynamics of oxidized and reduced cytochrome P450cam by Hamuro, Yoshitomo, Molnar, Kathleen S, Coales, Stephen J, OuYang, Bo, Simorellis, Alana K, Pochapsky, Thomas C

“…Backbone dynamics of the camphor monoxygenase cytochrome P450(cam) (CYP101) as a function of oxidation/ligation state of the heme iron were investigated via…”
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Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry by Schuster, Michael C., Ricklin, Daniel, Papp, Krisztián, Molnar, Kathleen S., Coales, Stephen J., Hamuro, Yoshitomo, Sfyroera, Georgia, Chen, Hui, Winters, Michael S., Lambris, John D.

“…Proteolytic cleavage of component C3 to C3b is a central step in the activation of complement. Whereas C3 is largely biologically inactive, C3b is directly…”
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Hydrogen/deuterium‐exchange (H/D‐Ex) of PPARγ LBD in the presence of various modulators by Hamuro, Yoshitomo, Coales, Stephen J., Morrow, Jeffrey A., Molnar, Kathleen S., Tuske, Steven J., Southern, Mark R., Griffin, Patrick R.

“…A nuclear receptor, peroxisome proliferator‐activated receptor γ (PPARγ), is a ligand‐dependent transcription factor involved in glucose homeostasis and…”
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Kindlin-3 Undergoes Endoproteolysis in Stored Platelets and After Platelet Stimulation by Streu, Craig N., Nygren, Patrik, Billings, Paul C., Moore, David T., Molnar, Kathleen S., DeGrado, William F., Bennett, Joel S.

“…Abstract 1255 Kindlins are a family of FERM domain proteins that are essential for inside-out integrin activation. In particular, kindlin-3 is required for the…”
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Elucidating the energetics of bacterial signal transduction: Insights from PhoQ by Molnar, Kathleen S

“…Bacteria transduce signals across the membrane using two-component systems, consisting of a membrane-spanning sensor histidine kinase and a cytoplasmic…”
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Hydrogen–deuterium exchange mass spectrometry for investigation of backbone dynamics of oxidized and reduced cytochrome P450 cam by Hamuro, Yoshitomo, Molnar, Kathleen S., Coales, Stephen J., OuYang, Bo, Simorellis, Alana K., Pochapsky, Thomas C.

“…Backbone dynamics of the camphor monoxygenase cytochrome P450 cam (CYP101) as a function of oxidation/ligation state of the heme iron were investigated via…”
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Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators by Hamuro, Yoshitomo, Coales, Stephen J, Morrow, Jeffrey A, Molnar, Kathleen S, Tuske, Steven J, Southern, Mark R, Griffin, Patrick R

“…A nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), is a ligand-dependent transcription factor involved in glucose homeostasis…”
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