Search Results - "MOLNAR, Eva"
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Issues, challenges, directives, and limitations concerning the improvement of environmental risk assessment of pharmaceutically active compounds
Published in Ecotoxicology and environmental safety (15-06-2021)“…Nowadays, when tons of different chemicals including pharmaceutically active compounds (PhACs) are known to be released into the environment, applying adequate…”
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The potential for nanoparticle-based drug delivery to the brain: overcoming the blood-brain barrier
Published in Expert opinion on drug delivery (01-06-2009)“…The development of blood-brain barrier (BBB)-targeting technologies is a very active field of research: targeting therapeutic actives to the central nervous…”
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In Vitro Assessment of Alkylglyceryl-Functionalized Chitosan Nanoparticles as Permeating Vectors for the Blood–Brain Barrier
Published in Biomacromolecules (09-04-2012)“…A series of O-substituted alkylglyceryl chitosans with systematically varied alkyl chain length and degree of grafting has been employed for the formulation of…”
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Ethyne Functionalized Meso -Phenothiazinyl-Phenyl-Porphyrins: Synthesis and Optical Properties of Free Base Versus Protonated Species
Published in Molecules (Basel, Switzerland) (04-10-2020)“…Synthesis, structural characterization and photophysical properties for a series of new -A B - and A B-type ethynyl functionalized -phenothiazinyl-phenyl…”
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Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: Preparation and in vitro investigation
Published in Acta biomaterialia (01-09-2015)“…[Display omitted] Poly(lactic acid), which has an inherent tendency to form colloidal systems of low polydispersity, and alkylglyceryl-modified dextran – a…”
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Measurement of factor XIII activity in plasma
Published in Clinical chemistry and laboratory medicine (01-07-2012)“…Coagulation factor XIII (FXIII) is converted by thrombin and Ca(2+) into an active transglutaminase (FXIIIa) in the final phase of coagulation cascade. Its…”
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Novel Phenothiazine-Bridged Porphyrin-(Hetero)aryl dyads: Synthesis, Optical Properties, In Vitro Cytotoxicity and Staining of Human Ovarian Tumor Cell Lines
Published in International journal of molecular sciences (30-04-2020)“…We report here the synthetic procedure applied for the preparation of new AB -type and -A B type -halogenophenothiazinyl-phenyl-porphyrin derivatives, their…”
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Species specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2)
Published in Drug metabolism and pharmacokinetics (01-06-2017)“…The purpose of this study was to characterize the uptake of carnitine, the physiological substrate, and the uptake of 3-(2,2,2-trimethylhydrazinium)propionate,…”
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Occurrence and Fate of Macrolide Antibiotics in Wastewater Treatment Plants and in the Glatt Valley Watershed, Switzerland
Published in Environmental science & technology (15-12-2003)“…An analytical method was developed for determining macrolide antibiotics in treated wastewater effluents and in ambient water based on solid-phase extraction…”
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Toward Drug Delivery into the Brain: Synthesis, Characterization, and Preliminary In Vitro Assessment of Alkylglyceryl-Functionalized Chitosan Nanoparticles
Published in Biomacromolecules (08-11-2010)“…A series of O-substituted alkylglyceryl chitosans with systematically varied degrees of grafting was prepared through synthetic steps that involved the…”
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Factor XIII levels and factor XIII B subunit polymorphisms in patients with venous thromboembolism
Published in Thrombosis research (01-10-2017)“…The association of plasma factor XIII (FXIII) level with venous thromboembolism (VTE) is still controversial and the effect of sex and FXIII B subunit…”
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Kinetic Characterization of Sulfasalazine Transport by Human ATP-Binding Cassette G2
Published in Biological & Pharmaceutical Bulletin (01-03-2009)“…The pharmacokinetics of sulfasalazine, an anti-inflammatory drug is influenced by ATP-binding cassette G2 (ABCG2) (breast cancer resistance protein (BCRP),…”
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Lovastatin interferes with the infarct size-limiting effect of ischemic preconditioning and postconditioning in rat hearts
Published in American journal of physiology. Heart and circulatory physiology (01-05-2008)“…Statins have been shown to be cardioprotective; however, their interaction with endogenous cardioprotection by ischemic preconditioning and postconditioning is…”
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Effects of pharmaceutically active compounds (PhACs) on fish body and scale shape in natural waters
Published in PeerJ (San Francisco, CA) (11-02-2021)“…In recent years, there are growing concerns about pharmaceutically active compounds (PhACs) in natural ecosystems. These compounds have been found in natural…”
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ABCG2 (Breast Cancer Resistance Protein/Mitoxantrone Resistance-Associated Protein) ATPase Assay: A Useful Tool to Detect Drug-Transporter Interactions
Published in Drug metabolism and disposition (01-09-2007)“…The ATPase assay using membrane preparations from recombinant baculovirus-infected Spodoptera frugiperda ovarian (Sf9) cells is widely used to detect the…”
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Correlation Analysis of Potential Breast Cancer Resistance Protein Probes in Different Monolayer Systems
Published in Journal of pharmaceutical sciences (01-11-2018)“…Breast cancer resistance protein (BCRP) is a point of interest in drug-drug interaction safety testing. Therefore, a consensus probe that can be applied as…”
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Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3
Published in Journal of pharmaceutical sciences (01-05-2013)“…The thiazide diuretic chlorothiazide is poorly metabolized, and is predominantly excreted via the kidneys. We have previously shown that chlorothiazide is…”
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Regulation of plasma factor XIII levels in healthy individuals; a major impact by subunit B intron K c.1952 + 144 C > G polymorphism
Published in Thrombosis research (01-12-2016)“…Abstract Background The regulation of plasma factor XIII (FXIII) levels in healthy individuals has been only partially explored. The identification of major…”
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On a class of inequality problems with lack of compactness
Published in Journal of mathematical analysis and applications (15-06-2011)“…In this paper we prove the existence of at least one solution for a variational–hemivariational inequality on a closed and convex set without using critical…”
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Pedagogising Knowledge in Multigrade Roma Schools: Potentials and Tensions of Innovation
Published in European educational research journal EERJ (01-06-2014)“…Low school achievement and frequent dropout of Hungarian Roma students from primary education is mostly an effect of inadequate curriculum content and teaching…”
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