Search Results - "MOLLINEDO, Faustino"

Neutrophil Degranulation, Plasticity, and Cancer Metastasis by Mollinedo, Faustino

“…Neutrophils are the first responders to inflammation and infection. Recently, an elevated neutrophil-to-lymphocyte ratio has generally become a prognostic…”
Get full text

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy by Mollinedo, Faustino, Gajate, Consuelo

“…Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways…”
Get full text

Lipid rafts as major platforms for signaling regulation in cancer by Mollinedo, Faustino, Gajate, Consuelo

“…Cell signaling does not apparently occur randomly over the cell surface, but it seems to be integrated very often into cholesterol-rich membrane domains,…”
Get full text

Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release by García-Navas, Rósula, Gajate, Consuelo, Mollinedo, Faustino

“…Human neutrophils constitutively express high amounts of arginase-1, which depletes arginine from the surrounding medium and downregulates T-cell activation…”
Get full text

Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling by Gajate, Consuelo, Mollinedo, Faustino

“…Membrane lipid rafts are highly ordered membrane domains enriched in cholesterol, sphingolipids and gangliosides that have the property to segregate and…”
Get full text

Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine by Gajate, Consuelo, Mollinedo, Faustino

“…The so-called alkylphospholipid analogs (APLs) constitute a family of synthetic antitumor compounds that target cell membranes. The ether phospholipid…”
Get more information

Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine by Mollinedo, Faustino, Gajate, Consuelo

“…The ether lipid edelfosine induces apoptosis selectively in tumor cells and is the prototypic molecule of a family of synthetic antitumor compounds…”
Get full text

Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions by Gajate, Consuelo, Mollinedo, Faustino

“…Lipid raft domains, enriched in sphingolipids and cholesterol, serve as sorting platforms and hubs for signal transduction proteins, and show resistance to…”
Get more information

Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response by Mollinedo, Faustino, Gajate, Consuelo

Get full text

Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting by Dakir, EL-Habib, Gajate, Consuelo, Mollinedo, Faustino

“…Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer death among men worldwide. While the five-year survival in local and…”
Get full text

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells by Gajate, Consuelo, Gonzalez-Camacho, Fernando, Mollinedo, Faustino

“…Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis. By a…”
Get full text

Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes by García-Navas, Rósula, Munder, Markus, Mollinedo, Faustino

“…L-arginine (L-Arg) deficiency results in decreased T-cell proliferation and impaired T-cell function. Here we have found that L-Arg depletion inhibited…”
Get full text

Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells by Álvarez, Raquel, Gajate, Consuelo, Puebla, Pilar, Mollinedo, Faustino, Medarde, Manuel, Peláez, Rafael

“…Resistance to combretastatin A-4 is mediated by metabolic modification of the phenolic hydroxyl and ether groups of the 3-hydroxy-4-methoxyphenyl (B ring)…”
Get full text

Lipid raft connection between extrinsic and intrinsic apoptotic pathways by Gajate, Consuelo, Gonzalez-Camacho, Fernando, Mollinedo, Faustino

“…Apoptosis in mammalian cells is modulated by extrinsic and intrinsic signaling pathways through the formation of death receptor-mediated death-inducing…”
Get full text

Cytoskeleton-mediated Death Receptor and Ligand Concentration in Lipid Rafts Forms Apoptosis-promoting Clusters in Cancer Chemotherapy by Gajate, Consuelo, Mollinedo, Faustino

“…While investigating the mechanism of action of the novel antitumor drug Aplidin, we have discovered a potent and novel cell-killing mechanism that involves the…”
Get full text

Suppression of metastatic organ colonization and antiangiogenic activity of the orally bioavailable lipid raft-targeted alkylphospholipid edelfosine by Alonso-Pérez, Verónica, Hernández, Vanessa, Calzado, Marco A., Vicente-Blázquez, Alba, Gajate, Consuelo, Soler-Torronteras, Rafael, DeCicco-Skinner, Kathleen, Sierra, Angels, Mollinedo, Faustino

“…Metastasis is the leading cause of cancer mortality. Metastatic cancer is notoriously difficult to treat, and it accounts for the majority of cancer-related…”
Get full text

Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib by Sevilla‐Movilla, Silvia, Arellano‐Sánchez, Nohemí, Martínez‐Moreno, Mónica, Gajate, Consuelo, Sánchez‐Vencells, Anna, Valcárcel, Luis V, Agirre, Xabier, Valeri, Antonio, Martínez‐López, Joaquin, Prósper, Felipe, Mollinedo, Faustino, Teixidó, Joaquin

“…The interaction of multiple myeloma (MM) cells with the bone marrow (BM) microenvironment promotes MM cell retention, survival, and resistance to different…”
Get full text

Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy by Mollinedo, Faustino, Gajate, Consuelo

“…There is an imperative need to overcome the rather poor outcomes of current cancer chemotherapy with further development of novel targets and drugs. Direct…”
Get more information

New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure-activity relationships, and molecular modelling by Vicente-Blázquez, Alba, González, Myriam, Medarde, Manuel, Mollinedo, Faustino, Peláez, Rafael

“…Searching for improved indolesulfonamides with higher polarities, 45 new analogues with modifications on the sulfonamide nitrogen, the methoxyaniline, and/or…”
Get full text

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine by Villa-Pulgarín, Janny A, Gajate, Consuelo, Botet, Javier, Jimenez, Alberto, Justies, Nicole, Varela-M, Rubén E, Cuesta-Marbán, Álvaro, Müller, Ingrid, Modolell, Manuel, Revuelta, José L, Mollinedo, Faustino

“…Leishmaniasis is the world's second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from…”
Get full text