Search Results - "MOLLER, E"

Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action by Hallakou-Bozec, Sophie, Kergoat, Micheline, Fouqueray, Pascale, Bolze, Sébastien, Moller, David E

“…Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the…”
Get full text

Deep phenotyping of the unselected COPSAC2010 birth cohort study by Bisgaard, H., Vissing, N. H., Carson, C. G., Bischoff, A. L., Følsgaard, N. V., Kreiner-Møller, E., Chawes, B. L. K., Stokholm, J., Pedersen, L., Bjarnadóttir, E., Thysen, A. H., Nilsson, E., Mortensen, L. J., Olsen, S. F., Schjørring, S., Krogfelt, K. A., Lauritzen, L., Brix, S., Bønnelykke, K.

“…Summary Background We hypothesize that perinatal exposures, in particular the human microbiome and maternal nutrition during pregnancy, interact with the…”
Get full text

Lamina-dependent calibrated BOLD response in human primary motor cortex by Guidi, Maria, Huber, Laurentius, Lampe, Leonie, Gauthier, Claudine J., Möller, Harald E.

“…Disentangling neural activity at different cortical depths during a functional task has recently generated growing interest, since this would allow to separate…”
Get full text

FGF21-based pharmacotherapy – potential utility for metabolic disorders by Gimeno, Ruth E, Moller, David E

“…Highlights • FGF21 is a secreted protein that reduces glucose levels, decreases body weight, and decreases serum lipids in rodents and non-human primates. •…”
Get full text

Simultaneous Quantitative MRI Mapping of T1, T2 and Magnetic Susceptibility with Multi-Echo MP2RAGE by Metere, Riccardo, Kober, Tobias, Möller, Harald E, Schäfer, Andreas

“…The knowledge of relaxation times is essential for understanding the biophysical mechanisms underlying contrast in magnetic resonance imaging. Quantitative…”
Get full text

Acute exercise and motor memory consolidation: Does exercise type play a role? by Thomas, R., Flindtgaard, M., Skriver, K., Geertsen, S. S., Christiansen, L., Korsgaard Johnsen, L., Busk, D. V. P., Bojsen‐Møller, E., Madsen, M. J., Ritz, C., Roig, M., Lundbye‐Jensen, J.

“…A single bout of high‐intensity exercise can augment off‐line gains in skills acquired during motor practice. It is currently unknown if the type of physical…”
Get full text

Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes by Hallakou‐Bozec, Sophie, Vial, Guillaume, Kergoat, Micheline, Fouqueray, Pascale, Bolze, Sébastien, Borel, Anne‐Laure, Fontaine, Eric, Moller, David E.

“…Imeglimin is an investigational first‐in‐class novel oral agent for the treatment of type 2 diabetes (T2D). Several pivotal phase III trials have been…”
Get full text

Focused ethnography as an approach in medical education research by Andreassen, Pernille, Christensen, Mette K., Møller, Jane E.

“…Context Over recent decades, the use of qualitative methodologies has increased in medical education research. These include ethnographic approaches, which…”
Get full text

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes by Gaich, Gregory, Chien, Jenny Y., Fu, Haoda, Glass, Leonard C., Deeg, Mark A., Holland, William L., Kharitonenkov, Alexei, Bumol, Thomas, Schilske, Holger K., Moller, David E.

“…Fibroblast growth factor 21 (FGF21) is a recently discovered metabolic regulator. Exogenous FGF21 produces beneficial metabolic effects in animal models;…”
Get full text

Acute effects of physical activity patterns on plasma cortisol and brain-derived neurotrophic factor in relation to corticospinal excitability by Ekblom, Maria M., Bojsen-Møller, E., Blom, V., Tarassova, O., Moberg, M., Pontén, M., Wang, R., Ekblom, O.

“…Brain-derived neurotrophic factor (BDNF) and cortisol are both capable of modulating synaptic plasticity, but it is unknown how physical activity-induced…”
Get full text

THE MECHANISMS OF ACTION OF PPARS by Berger, Joel, Moller, David E

“…The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes…”
Get full text

The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity by Bojsen-Møller, E., Ekblom, M. M., Tarassova, O., Dunstan, D. W., Ekblom, O.

“…Paired associative stimulation (PAS) can induce plasticity in the motor cortex, as measured by changes in corticospinal excitability (CSE). This effect is…”
Get full text

Temporal trends in incidence and patient characteristics in cardiogenic shock following acute myocardial infarction from 2010 to 2017: a Danish cohort study by Helgestad, Ole K.L., Josiassen, Jakob, Hassager, Christian, Jensen, Lisette O., Holmvang, Lene, Sørensen, Anne, Frydland, Martin, Lassen, Annmarie T., Udesen, Nanna L.J., Schmidt, Henrik, Ravn, Hanne B., Møller, Jacob E.

“…Aim We sought to describe the contemporary annual incidence of cardiogenic shock (CS) following acute myocardial infarction (AMICS), the proportion of patients…”
Get full text

Early diastolic strain rate in relation to systolic and diastolic function and prognosis in acute myocardial infarction: a two-dimensional speckle-tracking study by Ersbøll, Mads, Andersen, Mads J, Valeur, Nana, Mogensen, Ulrik M, Fakhri, Yama, Fahkri, Yama, Thune, Jens J, Møller, Jacob E, Hassager, Christian, Søgaard, Peter, Køber, Lars

“…Diastolic dysfunction in acute myocardial infarction (MI) is associated with adverse outcome. Recently, the ratio of early mitral inflow velocity (E) to global…”
Get full text

Fibroblast Growth Factor 21 Corrects Obesity in Mice by Coskun, Tamer, Bina, Holly A, Schneider, Michael A, Dunbar, James D, Hu, Charlie C, Chen, Yanyun, Moller, David E, Kharitonenkov, Alexei

“…Fibroblast growth factor 21 (FGF21) is a metabolic regulator that provides efficient and durable glycemic and lipid control in various animal models. However,…”
Get full text

Metabolic syndrome: a clinical and molecular perspective by Moller, David E, Kaufman, Keith D

“…The metabolic syndrome is a cluster of interrelated common clinical disorders, including obesity, insulin resistance, glucose intolerance, hypertension, and…”
Get full text

Real diffusion-weighted MRI enabling true signal averaging and increased diffusion contrast by Eichner, Cornelius, Cauley, Stephen F., Cohen-Adad, Julien, Möller, Harald E., Turner, Robert, Setsompop, Kawin, Wald, Lawrence L.

“…This project aims to characterize the impact of underlying noise distributions on diffusion-weighted imaging. The noise floor is a well-known problem for…”
Get full text

Genetic associations with viral respiratory illnesses and asthma control in children by Loisel, D. A., Du, G., Ahluwalia, T. S., Tisler, C. J., Evans, M. D., Myers, R. A., Gangnon, R. E., Kreiner-Møller, E., Bønnelykke, K., Bisgaard, H., Jackson, D. J., Lemanske Jr, R. F., Nicolae, D. L., Gern, J. E., Ober, C.

“…Summary Background Viral respiratory infections can cause acute wheezing illnesses in children and exacerbations of asthma. Objective We sought to identify…”
Get full text

Incidence of cancer in patients with chronic heart failure: a long-term follow-up study by Banke, Ann, Schou, Morten, Videbæk, Lars, Møller, Jacob E., Torp-Pedersen, Christian, Gustafsson, Finn, Dahl, Jordi S., Køber, Lars, Hildebrandt, Per R., Gislason, Gunnar H.

“…Aims With improvement in survival of chronic heart failure (HF), the clinical importance of co‐morbidity is increasing. The aim of this study was to assess the…”
Get full text

Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 by Kharitonenkov, Alexei, Beals, John M, Micanovic, Radmila, Strifler, Beth A, Rathnachalam, Radhakrishnan, Wroblewski, Victor J, Li, Shun, Koester, Anja, Ford, Amy M, Coskun, Tamer, Dunbar, James D, Cheng, Christine C, Frye, Christopher C, Bumol, Thomas F, Moller, David E

“…Fibroblast growth factor 21 is a novel hormonal regulator with the potential to treat a broad variety of metabolic abnormalities, such as type 2 diabetes,…”
Get full text