Search Results - "MOLEY, Kelle H"

Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations by Saben, Jessica L., Boudoures, Anna L., Asghar, Zeenat, Thompson, Alysha, Drury, Andrea, Zhang, Wendy, Chi, Maggie, Cusumano, Andrew, Scheaffer, Suzanne, Moley, Kelle H.

“…Maternal obesity impairs offspring health, but the responsible mechanisms are not fully established. To address this question, we fed female mice a…”
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High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects by Luzzo, Kerri M, Wang, Qiang, Purcell, Scott H, Chi, Maggie, Jimenez, Patricia T, Grindler, Natalia, Schedl, Tim, Moley, Kelle H

“…Maternal obesity is associated with poor outcomes across the reproductive spectrum including infertility, increased time to pregnancy, early pregnancy loss,…”
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Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes by Han, Longsen, Ren, Chao, Li, Ling, Li, Xiaoyan, Ge, Juan, Wang, Haichao, Miao, Yi-Liang, Guo, Xuejiang, Moley, Kelle H., Shu, Wenjie, Wang, Qiang

“…Maternal obesity can impair embryo development and offspring health, yet the mechanisms responsible remain poorly understood. In a high-fat diet (HFD)-based…”
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Obesity and female infertility: potential mediators of obesity's impact by Broughton, Darcy E., M.D, Moley, Kelle H., M.D

“…The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of American women of reproductive age. Obesity is associated with many…”
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Interferon lambda protects the female reproductive tract against Zika virus infection by Caine, Elizabeth A., Scheaffer, Suzanne M., Arora, Nitin, Zaitsev, Konstantin, Artyomov, Maxim N., Coyne, Carolyn B., Moley, Kelle H., Diamond, Michael S.

“…Although Zika virus (ZIKV) can be transmitted sexually and cause congenital birth defects, immune control mechanisms in the female reproductive tract (FRT) are…”
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Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging by Ben‐Meir, Assaf, Burstein, Eliezer, Borrego‐Alvarez, Aluet, Chong, Jasmine, Wong, Ellen, Yavorska, Tetyana, Naranian, Taline, Chi, Maggie, Wang, Ying, Bentov, Yaakov, Alexis, Jennifer, Meriano, James, Sung, Hoon‐Ki, Gasser, David L., Moley, Kelle H., Hekimi, Siegfried, Casper, Robert F., Jurisicova, Andrea

“…Summary Female reproductive capacity declines dramatically in the fourth decade of life as a result of an age‐related decrease in oocyte quality and quantity…”
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Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis by DeBosch, Brian J, Heitmeier, Monique R, Mayer, Allyson L, Higgins, Cassandra B, Crowley, Jan R, Kraft, Thomas E, Chi, Maggie, Newberry, Elizabeth P, Chen, Zhouji, Finck, Brian N, Davidson, Nicholas O, Yarasheski, Kevin E, Hruz, Paul W, Moley, Kelle H

“…Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to…”
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The facilitative glucose transporter GLUT3: 20 years of distinction by Simpson, Ian A, Dwyer, Donard, Malide, Daniela, Moley, Kelle H, Travis, Alexander, Vannucci, Susan J

“…Glucose metabolism is vital to most mammalian cells, and the passage of glucose across cell membranes is facilitated by a family of integral membrane…”
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Current knowledge of obesity's effects in the pre- and periconceptional periods and avenues for future research by Jungheim, Emily S., MD, MSCI, Moley, Kelle H., MD

“…The prevalence of obesity is growing among reproductive-age women. This is concerning because obesity has significant health-related consequences. Aside from…”
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Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy by Rhee, Julie S., Saben, Jessica L., Mayer, Allyson L., Schulte, Maureen B., Asghar, Zeenat, Stephens, Claire, Chi, Maggie M.-Y., Moley, Kelle H.

“…Abstract STUDY QUESTION What effect does diet-induced obesity have on endometrial stromal cell (ESC) decidualization? SUMMARY ANSWER Diet-induced obesity…”
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Diet-Induced Obesity Model: Abnormal Oocytes and Persistent Growth Abnormalities in the Offspring by Jungheim, Emily S, Schoeller, Erica L, Marquard, Kerri L, Louden, Erica D, Schaffer, Jean E, Moley, Kelle H

“…Associations between maternal obesity and adverse fetal outcomes are well documented, but the mechanisms involved are largely unknown. Most previous work has…”
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Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles by Frolova, Antonina I, Moley, Kelle H

“…Facilitative glucose transport molecules (glucose transporters, GLUTs) are responsible for glucose transport across cellular membranes. Of the 14 family…”
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Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization by Jungheim, Emily S., M.D., M.S.C.I, Macones, George A., M.D., M.S.C.E, Odem, Randall R., M.D, Patterson, Bruce W., Ph.D, Lanzendorf, Susan E., Ph.D, Ratts, Valerie S., M.D, Moley, Kelle H., M.D

“…Objective To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology. Design Prospective cohort study…”
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Quantitative Analysis of Glucose Transporter mRNAs in Endometrial Stromal Cells Reveals Critical Role of GLUT1 in Uterine Receptivity by Frolova, Antonina I, Moley, Kelle H

“…GLUT1 mRNA is the most abundant glucose transporter mRNA in endometrial stroma cells, and decreasing expression by short hairpin RNA leads to suppression of…”
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Effects of obesity on hormonally driven cancer in women by Moley, Kelle H, Colditz, Graham A

“…Obesity increases the risk of numerous poor health outcomes, including cancer. Obesity is especially problematic in women because both they and their offspring…”
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Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation by Schulte, Maureen M B, Tsai, Jui-he, Moley, Kelle H

“…Successful embryonic implantation is the result of a receptive endometrium, a functional embryo at the blastocyst stage and a synchronized dialog between…”
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Insulin Rescues Impaired Spermatogenesis via the Hypothalamic-Pituitary-Gonadal Axis in Akita Diabetic Mice and Restores Male Fertility by SCHOELLER, Erica L, ALBANNA, Gabriella, FROLOVA, Antonina I, MOLEY, Kelle H

“…The mechanism responsible for poor reproductive outcomes in type 1 diabetic males is not well understood. In light of new evidence that the Sertoli cells of…”
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Diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases by Zhao, Zhen, Moley, Kelle H., Gronowski, Ann M.

“…Discovery of circulating miRNAs in maternal blood has not only facilitated the understanding of their role in normal pregnancy, but also paved new avenues for…”
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Facilitative glucose transporter 9, a unique hexose and urate transporter by Doblado, Manuel, Moley, Kelle H

“…GLUT9 is a novel, facilitative glucose transporter isoform that exists as two alternative splice variants encoding two proteins that differ in their…”
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The autophagy protein, FIP200 (RB1CC1) mediates progesterone responses governing uterine receptivity and decidualization by Oestreich, Arin K, Chadchan, Sangappa B, Medvedeva, Alexandra, Lydon, John P, Jungheim, Emily S, Moley, Kelle H, Kommagani, Ramakrishna

“…Successful establishment of pregnancy depends on steroid hormone-driven cellular changes in the uterus during the peri-implantation period. To become receptive…”
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