Search Results - "MOLES, Anna"

Dental disease reflects differential diets and changes in consumption over time at Knossos by Moles, Anna C.

“…Knossos was an important city on Crete and within Mediterranean networks during the Hellenistic, Roman, and Late Antique periods. However, there were…”
Get full text

NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake by Alari-Pahissa, Elisenda, Ataya, Michelle, Moraitis, Ilias, Campos-Ruiz, Miriam, Altadill, Mireia, Muntasell, Aura, Moles, Anna, López-Botet, Miguel

“…Epstein Barr virus (EBV) causes a highly prevalent and lifelong infection contributing to the development of some malignancies. In addition to the key role…”
Get full text

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis by Martínez-Fábregas, Jonathan, Prescott, Alan, van Kasteren, Sander, Pedrioli, Deena Leslie, McLean, Irwin, Moles, Anna, Reinheckel, Thomas, Poli, Valeria, Watts, Colin

“…Diverse cellular processes depend on the lysosomal protease system but how cells regulate lysosomal proteolytic capacity is only partly understood. We show…”
Get full text

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse by Moles, Anna, Murphy, Lindsay, Wilson, Caroline L, Chakraborty, Jayashree Bagchi, Fox, Christopher, Park, Eek Joong, Mann, Jelena, Oakley, Fiona, Howarth, Rachel, Brain, John, Masson, Steven, Karin, Michael, Seki, Ekihiro, Mann, Derek A

“…Background & Aims Neutrophils are important immune effectors required for sterile and non-sterile inflammatory responses. However, neutrophils are associated…”
Get full text

Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity by Moles, Anna, Torres, Sandra, Baulies, Anna, Garcia-Ruiz, Carmen, Fernandez-Checa, Jose C

“…Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major indication for liver transplantion in the United States and Europe…”
Get full text

Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy by De Pasquale, Valeria, Moles, Anna, Pavone, Luigi Michele

“…Cathepsins (CTSs) are ubiquitously expressed proteases normally found in the endolysosomal compartment where they mediate protein degradation and turnover…”
Get full text

Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake by Provensi, Gustavo, Coccurello, Roberto, Umehara, Hayato, Munari, Leonardo, Giacovazzo, Giacomo, Galeotti, Nicoletta, Nosi, Daniele, Gaetani, Silvana, Romano, Adele, Moles, Anna, Blandina, Patrizio, Passani, Maria Beatrice

“…Key factors driving eating behavior are hunger and satiety, which are controlled by a complex interplay of central neurotransmitter systems and peripheral…”
Get full text

Ductular reaction promotes intrahepatic angiogenesis through Slit2–Roundabout 1 signaling by Coll, Mar, Ariño, Silvia, Martínez‐Sánchez, Celia, Garcia‐Pras, Ester, Gallego, Javier, Moles, Anna, Aguilar‐Bravo, Beatriz, Blaya, Delia, Vallverdú, Julia, Rubio‐Tomás, Teresa, Lozano, Juan Jose, Pose, Elisa, Graupera, Isabel, Fernández‐Vidal, Andrea, Pol, Albert, Bataller, Ramón, Geng, Jian‐Guo, Ginès, Pere, Fernandez, Mercedes, Sancho‐Bru, Pau

“…Background and Aims Ductular reaction (DR) expands in chronic liver diseases and correlates with disease severity. Besides its potential role in liver…”
Get full text

Searching for novel cellular targets for MASLD and HCC within the humble lysosomal cathepsins by Alejandro del Castillo-Cruz, Maria Fernández-Fernández, Anna Moles

“…Metabolic-associated steatotic liver disease (MASLD) and its pathological version, metabolic dysfunction-associated steatohepatitis (MASH), are becoming the…”
Get full text

Selection and characterization of human scFvs targeting the SARS-CoV-2 nucleocapsid protein isolated from antibody libraries of COVID-19 patients by Lisi, Simonetta, Malerba, Francesca, Quaranta, Paola, Florio, Rita, Vitaloni, Ottavia, Monaca, Elisa, Bruni Ercole, Bruno, Bitonti, Angela Rachel, del Perugia, Olga, Mignanelli, Marianna, Perrera, Paola, Sabbatella, Raffaele, Raimondi, Francesco, Piazza, Carmen Rita, Moles, Anna, Alfano, Caterina, Pistello, Mauro, Cattaneo, Antonino

“…In 2019, the novel SARS-CoV-2 coronavirus emerged in China, causing the pneumonia named COVID-19. At the beginning, all research efforts were focused on the…”
Get full text

Author Correction: Selection and characterization of human scFvs targeting the SARS-CoV-2 nucleocapsid protein isolated from antibody libraries of COVID-19 patients by Lisi, Simonetta, Malerba, Francesca, Quaranta, Paola, Florio, Rita, Vitaloni, Ottavia, Monaca, Elisa, Ercole, Bruno Bruni, Bitonti, Angela Rachel, del Perugia, Olga, Mignanelli, Marianna, Perrera, Paola, Sabbatella, Rafaele, Raimondi, Francesco, Piazza, Carmen Rita, Moles, Anna, Alfano, Caterina, Pistello, Mauro, Cattaneo, Antonino

Get full text

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease by Ebrahimkhani, Mohammad R, Oakley, Fiona, Murphy, Lindsay B, Mann, Jelena, Moles, Anna, Perugorria, Maria J, Ellis, Elizabeth, Lakey, Anne F, Burt, Alastair D, Douglass, Angela, Wright, Matthew C, White, Steven A, Jaffré, Fabrice, Maroteaux, Luc, Mann, Derek A

“…Wound healing involves a transient regeneration of tissue, but, if this process continues unabated, pathology occurs in the form of fibrosis, which can prevent…”
Get full text

Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs by Voellenkle, Christine, Rooij, Jeroen van, Guffanti, Alessandro, Brini, Elena, Fasanaro, Pasquale, Isaia, Eleonora, Croft, Larry, David, Matei, Capogrossi, Maurizio C, Moles, Anna, Felsani, Armando, Martelli, Fabio

“…In order to understand the role of microRNAs (miRNAs) in vascular physiopathology, we took advantage of deep-sequencing techniques to accurately and…”
Get full text

Transient exposure to low levels of insecticide affects metabolic networks of honeybee larvae by Derecka, Kamila, Blythe, Martin J, Malla, Sunir, Genereux, Diane P, Guffanti, Alessandro, Pavan, Paolo, Moles, Anna, Snart, Charles, Ryder, Thomas, Ortori, Catharine A, Barrett, David A, Schuster, Eugene, Stöger, Reinhard

“…The survival of a species depends on its capacity to adjust to changing environmental conditions, and new stressors. Such new, anthropogenic stressors include…”
Get full text

Stable isotopes reveal dietary shifts associated with social change in Hellenistic, Roman and Late Antique Knossos by Moles, Anna C., Reade, Hazel, Jourdan, Anne-Lise, Stevens, Rhiannon E.

“…•Diet at ancient Knossos, Crete, in Greece changed in line with major social changes.•Stable isotope analysis of human remains highlights dietary changes.•Most…”
Get full text

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease by Fox, Christopher, Cocchiaro, Pasquale, Oakley, Fiona, Howarth, Rachel, Callaghan, Krystena, Leslie, Jack, Luli, Saimir, Wood, Katrina M., Genovese, Federica, Sheerin, Neil S., Moles, Anna

“…During chronic kidney disease (CKD) there is a dysregulation of extracellular matrix (ECM) homeostasis leading to renal fibrosis. Lysosomal proteases such as…”
Get full text

Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis by Paloma Ruiz-Blázquez, Júlia Cacho-Pujol, Anna Moles

“…Lysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as…”
Get full text

Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members by Megiorni, Francesca, Cialfi, Samantha, McDowell, Heather P, Felsani, Armando, Camero, Simona, Guffanti, Alessandro, Pizer, Barry, Clerico, Anna, De Grazia, Alessandra, Pizzuti, Antonio, Moles, Anna, Dominici, Carlo

“…Rhabdomyosarcoma (RMS) is a highly malignant tumour accounting for nearly half of soft tissue sarcomas in children. MicroRNAs (miRNAs) represent a class of…”
Get full text

The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease by Cocchiaro, Pasquale, De Pasquale, Valeria, Della Morte, Rossella, Tafuri, Simona, Avallone, Luigi, Pizard, Anne, Moles, Anna, Pavone, Luigi Michele

“…Kidney disease is worldwide the 12th leading cause of death affecting 8-16% of the entire population. Kidney disease encompasses acute (short-lasting episode)…”
Get full text

Postnatal aversive experience impairs sensitivity to natural rewards and increases susceptibility to negative events in adult life by Ventura, Rossella, Coccurello, Roberto, Andolina, Diego, Latagliata, Emanuele Claudio, Zanettini, Claudio, Lampis, Valentina, Battaglia, Marco, D'Amato, Francesca R, Moles, Anna

“…Evidence shows that maternal care and postnatal traumatic events can exert powerful effects on brain circuitry development but little is known about the impact…”
Get full text