Search Results - "MOLECULAR CANCER RESEARCH"

Antibody-Drug Conjugates: A Comprehensive Review by Khongorzul, Puregmaa, Ling, Cai Jia, Khan, Farhan Ullah, Ihsan, Awais Ullah, Zhang, Juan

“…Antibody-drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a…”
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A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer by Yang, Wen-Hsuan, Huang, Zhiqing, Wu, Jianli, Ding, Chien-Kuang C, Murphy, Susan K, Chi, Jen-Tsan

“…Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating novel therapeutic approaches. To…”
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Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis by Lee, Young-Sun, Lee, Dae-Hee, Choudry, Haroon A, Bartlett, David L, Lee, Yong J

“…Since its discovery in 2012, ferroptosis has been well characterized by the accumulation of lipid peroxides due to the failure of glutathione-dependent…”
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Internalization of Exosomes through Receptor-Mediated Endocytosis by Gonda, Amber, Kabagwira, Janviere, Senthil, Girish N, Wall, Nathan R

“…The tumor microenvironment is replete with factors secreted and internalized by surrounding cells. Exosomes are nano-sized, protein-embedded, membrane-bound…”
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The MEK/ERK Network as a Therapeutic Target in Human Cancer by Barbosa, Renee, Acevedo, Lucila A, Marmorstein, Ronen

“…The RAS-RAF-MEK-ERK pathway is the most well-studied of the MAPK cascades and is critical for cell proliferation, differentiation, and survival. Abnormalities…”
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Updating the Definition of Cancer by Brown, Joel S, Amend, Sarah R, Austin, Robert H, Gatenby, Robert A, Hammarlund, Emma U, Pienta, Kenneth J

“…Most definitions of cancer broadly conform to the current NCI definition: "Cancer is a disease in which some of the body's cells grow uncontrollably and spread…”
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PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow by Hopkins, Todd A, Ainsworth, William B, Ellis, Paul A, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Abraham, Vivek C, Algire, Mikkel A, Shi, Yan, Olson, Amanda M, Johnson, Eric F, Wilsbacher, Julie L, Maag, David

“…PARP inhibitors have recently been approved as monotherapies for the treatment of recurrent ovarian cancer and metastatic -associated breast cancer, and…”
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Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling by Ringuette Goulet, Cassandra, Bernard, Geneviève, Tremblay, Sarah, Chabaud, Stéphane, Bolduc, Stéphane, Pouliot, Frédéric

“…A particularly important tumor microenvironment relationship exists between cancer cells and surrounding stromal cells. Fibroblasts, in response to cancer…”
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Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis by Maji, Sayantan, Chaudhary, Pankaj, Akopova, Irina, Nguyen, Phung M, Hare, Richard J, Gryczynski, Ignacy, Vishwanatha, Jamboor K

“…Tumor-derived exosomes are emerging mediators of tumorigenesis and tissue-specific metastasis. Proteomic profiling has identified Annexin II as one of the most…”
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Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers by Salem, Mohamed E, Puccini, Alberto, Grothey, Axel, Raghavan, Derek, Goldberg, Richard M, Xiu, Joanne, Korn, W Michael, Weinberg, Benjamin A, Hwang, Jimmy J, Shields, Anthony F, Marshall, John L, Philip, Philip A, Lenz, Heinz-Josef

“…The efficacy of immunotherapy varies widely among different gastrointestinal cancers. Response to immune checkpoint inhibitors is shown to correlate with tumor…”
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Cell-free DNA (cfDNA): Clinical Significance and Utility in Cancer Shaped By Emerging Technologies by Volik, Stanislav, Alcaide, Miguel, Morin, Ryan D, Collins, Colin

“…Precision oncology is predicated upon the ability to detect specific actionable genomic alterations and to monitor their adaptive evolution during treatment to…”
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Exosomes from HNSCC Promote Angiogenesis through Reprogramming of Endothelial Cells by Ludwig, Nils, Yerneni, Saigopalakrishna S, Razzo, Beatrice M, Whiteside, Theresa L

“…For solid tumors, such as head and neck squamous cell carcinoma (HNSCC), an adequate blood supply is of critical importance for tumor development and…”
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Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation by Kumar, Pankaj, Dillon, Laura W, Shibata, Yoshiyuki, Jazaeri, Amir A, Jones, David R, Dutta, Anindya

“…Cell-free circulating linear DNA is being explored for noninvasive diagnosis and management of tumors and fetuses, the so-called liquid biopsy. Previously, we…”
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Epithelial-Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance by Gooding, Alex J, Schiemann, William P

“…Epithelial-mesenchymal transition (EMT) programs play essential functions in normal morphogenesis and organogenesis, including that occurring during mammary…”
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Hypoxic cancer-secreted exosomal miR-182-5p promotes glioblastoma angiogenesis by targeting Kruppel-like factor 2 and 4 by Xiong, Nanxiang, Li, Junjun, Yuan, Hongliang, Xu, Hao, Zhao, Hongyang

“…Glioblastoma (GBM) is the most lethal primary brain tumor and has a complex molecular profile. Hypoxia plays a critical role during tumor progression and in…”
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Understanding TERT Promoter Mutations: A Common Path to Immortality by Bell, Robert J A, Rube, H Tomas, Xavier-Magalhães, Ana, Costa, Bruno M, Mancini, Andrew, Song, Jun S, Costello, Joseph F

“…Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining telomere length, telomerase relieves a main barrier on cellular lifespan,…”
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HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers by Koneva, Lada A, Zhang, Yanxiao, Virani, Shama, Hall, Pelle B, McHugh, Jonathan B, Chepeha, Douglas B, Wolf, Gregory T, Carey, Thomas E, Rozek, Laura S, Sartor, Maureen A

“…The incidence of human papillomavirus (HPV)-related oropharynx cancer has steadily increased over the past two decades and now represents a majority of…”
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Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics by Goodspeed, Andrew, Heiser, Laura M, Gray, Joe W, Costello, James C

“…Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic alterations. Often, these changes underlie cancer development,…”
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The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2 by Yang, Wen-Hsuan, Lin, Chao-Chieh, Wu, Jianli, Chao, Pei-Ya, Chen, Kuan, Chen, Po-Han, Chi, Jen-Tsan

“…Ferroptosis is a new form of regulated cell death resulting from the accumulation of lipid-reactive oxygen species. A growing number of studies indicate…”
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Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells by Nakamura, Koji, Sawada, Kenjiro, Kinose, Yasuto, Yoshimura, Akihiko, Toda, Aska, Nakatsuka, Erika, Hashimoto, Kae, Mabuchi, Seiji, Morishige, Ken-Ichirou, Kurachi, Hirohisa, Lengyel, Ernst, Kimura, Tadashi

“…Epithelial ovarian cancer (EOC) cells metastasize within the peritoneal cavity and directly encounter human peritoneal mesothelial cells (HPMC) as the initial…”
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