Search Results - "MOKRA, Daniela"

New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis by Adamcakova, Jana, Mokra, Daniela

“…Inhalation of silica particles is an environmental and occupational cause of silicosis, a type of pneumoconiosis. Development of the lung silicosis is a unique…”
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Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis by Mokra, Daniela, Joskova, Marta, Mokry, Juraj

“…(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular…”
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Corticosteroids in Acute Lung Injury: The Dilemma Continues by Mokra, Daniela, Mikolka, Pavol, Kosutova, Petra, Mokry, Juraj

“…Acute lung injury (ALI) represents a serious heterogenous pulmonary disorder with high mortality. Despite improved understanding of the pathophysiology, the…”
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Phosphodiesterase Inhibitors in Acute Lung Injury: What Are the Perspectives? by Mokra, Daniela, Mokry, Juraj

“…Despite progress in understanding the pathophysiology of acute lung damage, currently approved treatment possibilities are limited to lung-protective…”
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Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases? by Mokra, Daniela, Adamcakova, Jana, Mokry, Juraj

“…(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions. EGCG acts as a strong antioxidant which…”
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Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics by Barosova, Romana, Baranovicova, Eva, Hanusrichterova, Juliana, Mokra, Daniela

“…Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in…”
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Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS by Kosutova, Petra, Mikolka, Pavol, Mokra, Daniela, Calkovska, Andrea

“…Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation, epithelial and endothelial…”
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Inhibitors of phosphodiesterases in the treatment of cough by Mokry, Juraj, Urbanova, Anna, Kertys, Martin, Mokra, Daniela

“…•Xanthine derivatives inhibit PDEs non-selectively leading to bronchodilation, anti-inflammatory, and antitussive effects.•The inhibition of PDEs leads to…”
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Sex-Based Differences in Bronchial Asthma: What Are the Mechanisms behind Them? by Mokra, Daniela, Barosova, Romana, Mokry, Juraj

“…Sex-based differences in bronchial asthma can already be observed in childhood, at which time allergic atopic asthma is more frequently found in boys than in…”
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Editorial: Phosphodiesterases as Drug Targets in Airway and Inflammatory Diseases by Mokry, Juraj, Giembycz, Mark, Mokra, Daniela

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What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis? by Adamcakova Jana, Mokra Daniela

“…Lung silicosis is a serious pulmonary disease caused by an exposure of lung to inhaled silicon dioxide (SiO2) or silica. Although pathomechanisms of the…”
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Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis by Adamcakova, Jana, Balentova, Sona, Barosova, Romana, Hanusrichterova, Juliana, Mikolka, Pavol, Prso, Kristian, Mokry, Juraj, Tatarkova, Zuzana, Kalenska, Dagmar, Mokra, Daniela

“…Inhalation of silica particles causes inflammatory changes leading to fibrotizing silicosis. Considering a lack of effective therapy, and a growing information…”
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Advances in the Use of N-Acetylcysteine in Chronic Respiratory Diseases by Mokra, Daniela, Mokry, Juraj, Barosova, Romana, Hanusrichterova, Juliana

“…N-acetylcysteine (NAC) is widely used because of its mucolytic effects, taking part in the therapeutic protocols of cystic fibrosis. NAC is also administered…”
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Effects of PDE3 Inhibitor Olprinone on the Respiratory Parameters, Inflammation, and Apoptosis in an Experimental Model of Acute Respiratory Distress Syndrome by Kosutova, Petra, Mikolka, Pavol, Balentova, Sona, Adamkov, Marian, Calkovska, Andrea, Mokra, Daniela

“…This study aimed to investigate whether a selective phosphodiesterase-3 (PDE3) inhibitor olprinone can positively influence the inflammation, apoptosis, and…”
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Nitric-Oxide-Releasing Dexamethasone Derivative NCX-1005 Improves Lung Function and Attenuates Inflammation in Experimental Lavage-Induced ARDS by Kosutova, Petra, Kolomaznik, Maros, Calkovska, Andrea, Mokra, Daniela, Mikolka, Pavol

“…Acute respiratory distress syndrome (ARDS) is a common complication of critical illness and remains a major source of morbidity and mortality in the intensive…”
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How to overcome surfactant dysfunction in meconium aspiration syndrome? by Mokra, Daniela, Calkovska, Andrea

“…Highlights • Meconium is the earliest stools of a mammalian infant (or fetus). • Meconium-stained amniotic fluid occurs in about 10–15% of all pregnancies. •…”
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Recombinant Human Superoxide Dismutase and N -Acetylcysteine Addition to Exogenous Surfactant in the Treatment of Meconium Aspiration Syndrome by Kopincova, Jana, Kolomaznik, Maros, Mikolka, Pavol, Kosutova, Petra, Topercerova, Juliana, Matasova, Jr, Katarina, Calkovska, Andrea, Mokra, Daniela

“…This study aimed to evaluate the molecular background of -acetylcysteine (NAC) and recombinant human superoxide dismutase (rhSOD) antioxidant action when…”
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The Effect of Modified Porcine Surfactant Alone or in Combination with Polymyxin B on Lung Homeostasis in LPS-Challenged and Mechanically Ventilated Adult Rats by Kolomaznik, Maros, Kopincova, Jana, Nova, Zuzana, Topercerova, Juliana, Zila, Ivan, Mikolka, Pavol, Kosutova, Petra, Matasova, Jr, Katarina, Skovierova, Henrieta, Grendar, Marian, Mokra, Daniela, Calkovska, Andrea

“…The study aimed to prove the hypothesis that exogenous surfactant and an antibiotic polymyxin B (PxB) can more effectively reduce lipopolysaccharide…”
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Experimental Models of Pulmonary Fibrosis and their Translational Potential by Adamcakova Jana, Palova Romana, Mokra Daniela

“…Pulmonary fibrosis, represented mainly by idiopathic pulmonary fibrosis, develops chronic and progressive changes in lung parenchyma with high mortality and…”
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Effects of early dexamethasone treatment on several markers of inflammation and fibrosis in an animal model of lung silicosis in rats – A pilot study by Adamcakova Jana, Balentova Sona, Hanusrichterova Juliana, Barosova Romana, Mikolka Pavol, Prso Kristian, Mokry Juraj, Kalenska Dagmar, Kunertova Lenka, Mokra Daniela

“…Lung silicosis is primarily caused by inhalation of particles of silicon oxide (silica). Despite a huge progress in understanding the interactions among the…”
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