Search Results - "MOK, Vincent C. T"
-
1
Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
Published in Nature communications (02-05-2023)“…The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile…”
Get full text
Journal Article -
2
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
Published in Nature communications (04-09-2020)“…The molecular signatures of cells in the brain have been revealed in unprecedented detail, yet the ageing-associated genome-wide expression changes that may…”
Get full text
Journal Article -
3
LC–MS-Based Urinary Metabolite Signatures in Idiopathic Parkinson’s Disease
Published in Journal of proteome research (02-01-2015)“…Increasing evidence has shown that abnormal metabolic phenotypes in body fluids reflect the pathogenesis and pathophysiology of Parkinson’s disease (PD). These…”
Get full text
Journal Article -
4
Author Correction: An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish
Published in Nature communications (05-05-2023)Get full text
Journal Article -
5
An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish
Published in Nature communications (14-01-2023)“…Studying chemosensory processing desires precise chemical cue presentation, behavioral response monitoring, and large-scale neuronal activity recording. Here…”
Get full text
Journal Article -
6
Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial
Published in Alzheimer's research & therapy (04-12-2019)“…Dementia has been presenting an imminent public health challenge worldwide. Studies have shown a combination of cognitive and physical trainings may have…”
Get full text
Journal Article -
7
An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer's disease
Published in Alzheimer's research & therapy (12-01-2021)“…The differential diagnosis of frontotemporal dementia (FTD) and Alzheimer's disease (AD) is difficult due to the overlaps of clinical symptoms. Structural…”
Get full text
Journal Article -
8
Evaluation of oropharyngeal deglutitive pressure dynamics in patients with Parkinson's disease
Published in American journal of physiology: Gastrointestinal and liver physiology (01-04-2022)“…In Parkinson's disease (PD), oropharyngeal dysphagia is common and clinically relevant. The neurophysiology of dysphagia in PD is complex and incompletely…”
Get more information
Journal Article -
9
Construction of brain atlases based on a multi-center MRI dataset of 2020 Chinese adults
Published in Scientific reports (18-12-2015)“…Despite the known morphological differences (e.g., brain shape and size) in the brains of populations of different origins (e.g., age and race), the Chinese…”
Get full text
Journal Article -
10
Automatic Segmentation of Acute Ischemic Stroke From DWI Using 3-D Fully Convolutional DenseNets
Published in IEEE transactions on medical imaging (01-09-2018)“…Acute ischemic stroke is recognized as a common cerebral vascular disease in aging people. Accurate diagnosis and timely treatment can effectively improve the…”
Get full text
Journal Article -
11
The validity, reliability and clinical utility of the Hong Kong Montreal Cognitive Assessment (HK-MoCA) in patients with cerebral small vessel disease
Published in Dementia and geriatric cognitive disorders (01-01-2009)“…To evaluate the psychometric properties of the Hong Kong Montreal Cognitive Assessment (HK-MoCA) in patients with cerebral small vessel disease (SVD). 40 SVD…”
Get more information
Journal Article -
12
Neuropsychiatric Symptom Clusters in Stroke and Transient Ischemic Attack by Cognitive Status and Stroke Subtype: Frequency and Relationships with Vascular Lesions, Brain Atrophy and Amyloid
Published in PloS one (15-09-2016)“…The objectives of this study are 1) to examine the frequencies of neuropsychiatric symptom clusters in patients with stroke or transient ischemic attack (TIA)…”
Get full text
Journal Article -
13
Relations between Recent Past Leisure Activities with Risks of Dementia and Cognitive Functions after Stroke
Published in PloS one (25-07-2016)“…Leisure activity participation has been shown to lower risks of cognitive decline in non-stroke populations. However, effects of leisure activities…”
Get full text
Journal Article -
14
Evolution of intracranial atherosclerotic disease under modern medical therapy
Published in Annals of neurology (01-03-2015)“…Objective Understanding how symptomatic intracranial atherosclerotic disease (ICAD) evolves with current medical therapy may inform secondary stroke…”
Get full text
Journal Article -
15
Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner
Published in Communications biology (02-06-2021)“…Pharmacological reversal of brain aging is a long-sought yet challenging strategy for the prevention and treatment of age-related neurodegeneration, due to the…”
Get full text
Journal Article -
16
Abnormal organization of white matter network in patients with no dementia after ischemic stroke
Published in PloS one (13-12-2013)“…Structural changes after ischemic stroke could affect information communication extensively in the brain network. It is likely that the defects in the white…”
Get full text
Journal Article -
17
Hemodynamics and stroke risk in intracranial atherosclerotic disease
Published in Annals of neurology (01-05-2019)“…Objective To investigate whether hemodynamic features of symptomatic intracranial atherosclerotic stenosis (sICAS) might correlate with the risk of stroke…”
Get full text
Journal Article -
18
Cerebral Microbleeds: Is Antithrombotic Therapy Safe to Administer?
Published in Stroke (1970) (01-09-2014)Get full text
Journal Article -
19
The prognosis of acute symptomatic seizures after ischaemic stroke
Published in Journal of neurology, neurosurgery and psychiatry (01-01-2017)“…ObjectiveAcute symptomatic seizure (AS) after ischaemic stroke is defined as a seizure occurring ≤7 days of the stroke. There remains a lack of information on…”
Get full text
Journal Article -
20
Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization
Published in Diabetes (New York, N.Y.) (01-05-2022)“…Endothelial nitric oxide synthase (eNOS) monomerization and uncoupling play crucial roles in mediating vascular dysfunction in diabetes, although the…”
Get full text
Journal Article