Search Results - "MOIN, Kamiar"

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer by WITHANA, Nimali P, BIUM, Galia, SLOANE, Bonnie F, ANDERSON, Robin L, BOGYO, Matthew S, PARKER, Belinda S, SAMEN, Mansoureh, SLANEY, Clare, ANBALAGAN, Arulselvi, OLIVE, Mary B, BIDWELL, Bradley N, EDGINGTON, Laura, LING WANG, MOIN, Kamiar

“…Metastasis to bone is a major cause of morbidity in breast cancer patients, emphasizing the importance of identifying molecular drivers of bone metastasis for…”
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Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins by Rothberg, Jennifer M, Bailey, Kate M, Wojtkowiak, Jonathan W, Ben-Nun, Yael, Bogyo, Matthew, Weber, Ekkehard, Moin, Kamiar, Blum, Galia, Mattingly, Raymond R, Gillies, Robert J, Sloane, Bonnie F

“…One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that…”
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Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound by Ramalho, Suelem D, Sharma, Rajgopal, White, Jessica K, Aggarwal, Neha, Chalasani, Anita, Sameni, Mansoureh, Moin, Kamiar, Vieira, Paulo C, Turro, Claudia, Kodanko, Jeremy J, Sloane, Bonnie F

“…The cysteine protease cathepsin B has been causally linked to progression and metastasis of breast cancers. We demonstrate inhibition by a dipeptidyl nitrile…”
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Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor accumulation by Trivedi, Evan R, Harney, Allison S, Olive, Mary B, Podgorski, Izabela, Moin, Kamiar, Sloane, Bonnie F, Barrett, Anthony G.M, Meade, Thomas J, Hoffman, Brian M

“…A chiral porphyrazine (pz), H₂[pz(trans-A₂B₂)] (247), has been prepared that exhibits preferential in vivo accumulation in the cells of tumors. Pz 247 exhibits…”
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Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter by Hou, Zhanjun, Kugel Desmoulin, Sita, Etnyre, Erika, Olive, Mary, Hsiung, Benjamin, Cherian, Christina, Wloszczynski, Patrick A., Moin, Kamiar, Matherly, Larry H.

“…The proton-coupled folate transporter (PCFT; SLC46A1) is a proton-folate symporter that is abundantly expressed in solid tumors and normal tissues, such as…”
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Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer by ACUFF, Heath B, SINNAMON, Mark, SLOANE, Bonnie F, MATRISIAN, Lynn M, FINGLETON, Barbara, BOONE, Braden, LEVY, Shawn E, XIWU CHEN, POZZI, Ambra, CARBONE, David P, SCHWARTZ, Donald R, MOIN, Kamiar

“…We used a customized Affymetrix protease microarray (Hu/Mu ProtIn chip) designed to distinguish human and mouse genes to analyze the expression of proteases…”
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Functional imaging of tumor proteolysis by SLOANE, Bonnie F, SAMENI, Mansoureh, PODGORSKI, Izabela, CAVALLO-MEDVED, Dora, MOIN, Kamiar

“…The roles of proteases in cancer are now known to be much broader than simply degradation of extracellular matrix during tumor invasion and metastasis…”
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Imaging Proteolysis by Living Human Breast Cancer Cells by Sameni, Mansoureh, Moin, Kamiar, Sloane, Bonnie F.

“…Malignant progression is accompanied by degradation of extracellular matrix proteins. Here we describe a novel confocal assay in which we can observe…”
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Functional Imaging of Proteolysis: Stromal and Inflammatory Cells Increase Tumor Proteolysis by Sameni, Mansoureh, Dosescu, Julie, Moin, Kamiar, Sloane, Bonnie F.

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Interaction of Human Breast Fibroblasts with Collagen I Increases Secretion of Procathepsin B by Koblinski, Jennifer E, Dosescu, Julie, Sameni, Mansoureh, Moin, Kamiar, Clark, Katherine, Sloane, Bonnie F

“…Interactions of stromal and tumor cells with the extracellular matrix may regulate expression of proteases including the lysosomal proteases cathepsins B and…”
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Hu/Mu ProtIn Oligonucleotide Microarray: Dual-Species Array for Profiling Protease and Protease Inhibitor Gene Expression in Tumors and Their Microenvironment by Schwartz, Donald R, Moin, Kamiar, Yao, Bin, Matrisian, Lynn M, Coussens, Lisa M, Bugge, Thomas H, Fingleton, Barbara, Acuff, Heath B, Sinnamon, Mark, Nassar, Hind, Platts, Adrian E, Krawetz, Stephen A, Linebaugh, Bruce E, Sloane, Bonnie F

“…Proteolysis is a critical regulatory mechanism for a wide variety of physiologic and pathologic processes. To assist in the identification of proteases, their…”
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Molecular regulation, membrane association and secretion of tumor cathepsin B by FROSCH, BARBARA A., BERQUIN, ISABELLE, EMMERT-BUCK, MICHAEL R., MOIN, KAMIAR, SLOANE, BONNIE F.

“…Upregulation, membrane association and secretion of cathepsin B have been shown to occur in many types of tumors and to correlate positively with their…”
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Functional expression of recombinant human stefin A in mammalian and bacterial cells by Calkins, Catharine C., Dosescu, Julie, Day, Nancy A., Ren, Wei-Ping, Fridman, Rafael, Sloane, Bonnie F., Moin, Kamiar

“…Recombinant human cysteine protease inhibitor, stefin A, was expressed in both Escherichia coli and BS-C-1 monkey kidney cells utilizing pET and recombinant…”
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Carcinoma-Associated Fibroblasts Accelerate Growth and Invasiveness of Breast Cancer Cells in 3D Long-Term Breast Cancer Models by Osuala, Kingsley O., Heyza, Joshua, Zhao, Zhiguo, Xu, Yong, Moin, Kamiar, Ji, Kyungmin, Mattingly, Raymond R.

“…Background/Objectives: Carcinoma-associated fibroblasts (CAFs), a prominent cell type in the tumor microenvironment (TME), significantly contributes to cancer…”
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Cathepsin B and middle cerebral artery occlusion in the rat by SEYFRIED, D, HAN, Y, ZHENG, Z, DAY, N, MOIN, K, REMPEL, S, SLOANE, B, CHOPP, M

“…Lysosomal proteases, although tightly regulated under physiological conditions, are known to contribute to cell injury after various forms of tissue ischemia…”
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Paracrine Activation of STAT3 Drives GM-CSF Expression in Breast Carcinoma Cells, Generating a Symbiotic Signaling Network with Breast Carcinoma-Associated Fibroblasts by Osuala, Kingsley O, Chalasani, Anita, Aggarwal, Neha, Ji, Kyungmin, Moin, Kamiar

“…This study evaluated the paracrine signaling between breast carcinoma-associated fibroblasts (CAFs) and breast cancer (BCa) cells. Resolving cell-cell…”
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Spatio-temporal modeling and live-cell imaging of proteolysis in the 4D microenvironment of breast cancer by Ji, Kyungmin, Sameni, Mansoureh, Osuala, Kingsley, Moin, Kamiar, Mattingly, Raymond R., Sloane, Bonnie F.

“…Cells grown in three dimensions (3D) within natural extracellular matrices or synthetic scaffolds more closely recapitulate the phenotype of those cells within…”
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Disrupted intercellular bridges and spermatogenesis in fatty acyl‐CoA reductase 1 knockout mice: A new model of ether lipid deficiency by Pan, Bo, Yuan, Shuo, Mayernik, Linda, Yap, Yi Tian, Moin, Kamiar, Chung, Charles S., Maddipati, Krishnarao, Krawetz, Stephen A., Zhang, Zhibing, Hess, Rex A., Chen, Xuequn

“…Peroxisomal fatty acyl‐CoA reductase 1 (FAR1) is a rate‐limiting enzyme for ether lipid (EL) synthesis. Gene mutations in FAR1 cause a rare human disease…”
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Acidosis and proteolysis in the tumor microenvironment by Ji, Kyungmin, Mayernik, Linda, Moin, Kamiar, Sloane, Bonnie F.

“…The glycolytic phenotype of the Warburg effect is associated with acidification of the tumor microenvironment. In this review, we describe how acidification of…”
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Abstract 2131: Paracrine cytokine pathways mediate metastasis of breast cancer to lymphatics by Ji, Kyungmin, Zhao, Zhiguo, Moin, Kamiar, Xu, Yong, Gillies, Robert J., Mattingly, Raymond R., Sloane, Bonnie F.

“…Abstract Lymphatics, rather than blood vessels, are the primary route for breast cancer metastasis. The presence of breast cancer cells in regional lymphatics,…”
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