Search Results - "MOHELL, N"

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells by Mohell, N, Alfredsson, J, Fransson, Å, Uustalu, M, Byström, S, Gullbo, J, Hallberg, A, Bykov, V J N, Björklund, U, Wiman, K G

“…Two main causes of platinum resistance are mutation in the tumor suppressor gene TP53 and drug-induced increase in intracellular glutathione concentration…”
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The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine by WEINER, D. M, MELTZER, H. Y, VANOVER, K. E, OLSSON, R, JAYATHILAKE, K, LEE, M, LEVEY, A. I, HACKSELL, U, BURSTEIN, E. S, DAVIS, R. E, BRANN, M. R, VEINBERGS, I, DONOHUE, E. M, SPALDING, T. A, SMITH, T. T, MOHELL, N, HARVEY, S. C, LAMEH, J, NASH, N

“…Clozapine is a unique antipsychotic, with efficacy against positive symptoms in treatment-resistant schizophrenic patients, and the ability to improve…”
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Carbon-11-FLB 457: A Radioligand for Extrastriatal D2 Dopamine Receptors by Halldin, Christer, Farde, Lars, Hogberg, Thomas, Mohell, Nina, Hall, Hakan, Suhara, Tetsuya, Karlsson, Per, Nakashima, Yoshifumi, Swahn, Carl-Gunnar

“…D2 dopamine receptors in extrastriatal brain regions are of central interest for research in schizophrenia and antipsychotic drugs. This article reports the…”
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Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors by Malmberg, A, Jackson, D M, Eriksson, A, Mohell, N

“…In the present study we have compared the pharmacological properties of human dopamine (DA) D2A, D2B, and D3 receptors expressed in mammalian cell lines, using…”
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The beta-adrenergic radioligand [3H]CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue by Mohell, N, Dicker, A

“…The effect of CGP-12177, originally developed as a radioligand with antagonist properties for binding studies of beta-adrenergic receptors, was investigated in…”
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Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors by Malmberg, A, Nordvall, G, Johansson, A M, Mohell, N, Hacksell, U

“…The affinities of a series of stereochemically well defined 2-aminotetralin derivatives for cloned human dopamine D2A (443 amino acids) and D3 receptors…”
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Thermogenesis in brown adipocytes is inhibited by volatile anesthetic agents. A factor contributing to hypothermia in infants? by Ohlson, K B, Mohell, N, Cannon, B, Lindahl, S G, Nedergaard, J

“…In infants, nonshivering thermogenesis from brown adipose tissue provides an important source of heat for thermoregulation. Infants are known to have a high…”
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Characterization of [3H]quinpirole binding to human dopamine D2A and D3 receptors: effects of ions and guanine nucleotides by Malmberg, A, Mohell, N

“…The in vitro receptor binding characteristics of [3H]quinpirole to cloned human dopamine D2A (long isoform) and D3 receptors were investigated and compared…”
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Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer by Fransson, Åsa, Glaessgen, Daria, Alfredsson, Jessica, Wiman, Klas G, Bajalica-Lagercrantz, Svetlana, Mohell, Nina

“…Mutation in the tumor suppressor gene TP53 is an early event in the development of high-grade serous (HGS) ovarian cancer and is identified in more than 96 %…”
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Preclinical findings with new antipsychotic agents: what makes them atypical? by Jackson, D M, Ryan, C, Evenden, J, Mohell, N

“…Many early antipsychotics such as haloperidol, while effective in treating the symptoms of schizophrenia, cause detrimental side effects and moreover induce…”
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Cold acclimation induces desensitization to adenosine in brown fat cells without changing receptor binding by Unelius, L, Mohell, N, Nedergaard, J

“…The ability of brown fat cells isolated from control and cold-acclimated hamsters to respond to adenosine was investigated. In measurements of the rate of…”
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Physiological desensitization of beta 3-adrenergic responses in brown fat cells: involvement of a postreceptor process by Unelius, L, Bronnikov, G, Mohell, N, Nedergaard, J

“…To investigate a possible physiological desensitization process for beta 3-adrenergic responses, the effect of cold acclimation of hamsters on adrenergically…”
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Alpha 1-adrenergic receptors in brown adipose tissue. Thermogenic significance and mode of action by Mohell, N

“…The main function of brown adipose tissue (BAT) is to produce heat in response to cold. Norepinephrine (NE), released from sympathetic nerve terminals,…”
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APR-246, a new class anticancer compound in phase l/lla clinical trials by Liljebris, C., Mohell, N., Olaisson, E., Uhlin, T., Wiman, K. G., Lehmann, S.

“…Abstract only…”
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Neuropeptide Y‐family receptors Y 6 and Y 7 in chicken: Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region by Bromée, Torun, Sjödin, Paula, Fredriksson, Robert, Boswell, Tim, Larsson, Tomas A., Salaneck, Erik, Zoorob, Rima, Mohell, Nina, Larhammar, Dan

“…The peptides of the neuropeptide Y (NPY) family exert their functions, including regulation of appetite and circadian rhythm, by binding to G‐protein coupled…”
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Distinction between mechanisms underlying alpha 1- and beta-adrenergic respiratory stimulation in brown fat cells by Mohell, N, Connolly, E, Nedergaard, J

“…Experimental conditions are described for selective alpha 1- and beta-adrenergic stimulation of the respiration of brown fat cells. The dual agonist…”
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APR-246, a clinical-stage mutant p53-reactivating compound, resensitizes ovarian cancer cells to platinum compounds and doxorubicin by Mohell, N, Alfredsson, J, Fransson, A, Bykov, V, von Euler, M, Wiman, K, Bjorklund, U

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Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study by Sjödin, Paula, Holmberg, Sara K S, Akerberg, Helena, Berglund, Magnus M, Mohell, Nina, Larhammar, Dan

“…Interactions of the human NPY (neuropeptide Y) receptor Y1 with the two endogenous agonists NPY and peptide YY and two non-peptide antagonists were…”
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Novel 2-Aminotetralin and 3-AminoChroman Derivatives as Selective Serotonin 5-HT7 Receptor Agonists and Antagonists by Holmberg, Pär, Sohn, Daniel, Leideborg, Robert, Caldirola, Patrizia, Zlatoidsky, Pavel, Hanson, Sverker, Mohell, Nina, Rosqvist, Susanne, Nordvall, Gunnar, Johansson, Anette M, Johansson, Rolf

“…The understanding of the physiological role of the G-protein coupled serotonin 5-HT7 receptor is largely rudimentary. Therefore, selective and potent…”
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Alpha 1-adrenergic stimulation of phosphatidylinositol turnover and respiration of brown fat cells by Mohell, N, Wallace, M, Fain, J N

“…The alpha-adrenergic agonist phenylephrine (in the presence of the beta-adrenergic antagonist alprenolol) stimulated respiration and incorporation of…”
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