Search Results - "MOHAMED, Yassir A"
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The Immunomodulatory Effects of Honey and Associated Flavonoids in Cancer
Published in Nutrients (13-04-2021)“…Honey has exerted a high impact in the field of alternative medicine over many centuries. In addition to its wound healing, anti-microbial and antioxidant…”
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Viral Etiologies of Infant Bronchiolitis, Croup and Upper Respiratory Illness During 4 Consecutive Years
Published in The Pediatric infectious disease journal (01-09-2013)“…Prospective data on viral etiology and clinical characteristics of bronchiolitis and upper respiratory illness (URI) in infants are limited. This prospective…”
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Characterization of immunomodulatory responses induced by manuka honey
Published in Frontiers in immunology (02-11-2022)“…Manuka honey (MH) is known for its wound-healing, anti-microbial, anti-oxidant and anti-tumor properties. However, there is conflicting evidence regarding the…”
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Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor
Published in International journal of molecular sciences (05-09-2019)“…Aberrantly high levels of tyrosine-phosphorylated signal transducer and activator of transcription 3 (p-STAT3) are found constitutively in ~50% of human lung…”
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Oral administration of Manuka honey induces IFNγ-dependent resistance to tumor growth that correlates with beneficial modulation of gut microbiota composition
Published in Frontiers in immunology (20-02-2024)“…To investigate the potential of Manuka honey (MH) as an immunomodulatory agent in colorectal cancer (CRC) and dissect the underlying molecular and cellular…”
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Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer
Published in Frontiers in immunology (20-12-2022)“…The use of immune checkpoint inhibitors to treat cancer resulted in unprecedented and durable clinical benefits. However, the response rate among patients…”
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The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells
Published in Frontiers in oncology (14-08-2017)“…There is renewed interest in the potential use of natural compounds in cancer therapy. Previously, we demonstrated the anti-tumor properties of manuka honey…”
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Host and viral factors associated with severity of human rhinovirus–associated infant respiratory tract illness
Published in Journal of allergy and clinical immunology (01-04-2011)“…Background Risk factors for severe human rhinovirus (HRV)–associated infant illness are unknown. Objectives We sought to examine the role of HRV infection in…”
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Involvement of Acetylcholine Receptors in Cholinergic Pathway-Mediated Protection Against Autoimmune Diabetes
Published in Frontiers in immunology (15-05-2019)“…Type I diabetes (T1D) is a T cell-driven autoimmune disease that results in the killing of pancreatic β-cells and, consequently, loss of insulin production…”
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Cholinergic Activation Enhances Resistance to Oral Salmonella Infection by Modulating Innate Immune Defense Mechanisms at the Intestinal Barrier
Published in Frontiers in immunology (19-03-2018)“…Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory…”
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Induction of Hypergammaglobulinemia and Autoantibodies by Salmonella Infection in MyD88-Deficient Mice
Published in Frontiers in immunology (20-06-2018)“…Growing evidence indicates a link between persistent infections and the development of autoimmune diseases. For instance, the inability to control infection…”
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Salmonella-mediated tumor regression involves targeting of tumor myeloid suppressor cells causing a shift to M1-like phenotype and reduction in suppressive capacity
Published in Cancer Immunology, Immunotherapy (01-06-2014)“…The effectiveness of attenuated Salmonella in inhibiting tumor growth has been demonstrated in many therapeutic models, but the precise mechanisms remain…”
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Acute systemic exposure to silver-based nanoparticles induces hepatotoxicity and NLRP3-dependent inflammation
Published in Nanotoxicology (13-09-2016)“…Nanoparticles (NPs) are increasingly being commercialized for use in biomedicine. NP toxicity following acute or chronic exposure has been described, but…”
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Cholinergic Stimulation Prevents the Development of Autoimmune Diabetes: Evidence for the Modulation of Th17 Effector Cells via an IFNγ-Dependent Mechanism
Published in Frontiers in immunology (13-10-2016)“…Type I diabetes (T1D) results from T cell-mediated damage of pancreatic β-cells and loss of insulin production. The cholinergic anti-inflammatory pathway…”
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Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer
Published in JCI insight (19-05-2016)“…Despite major advances in early detection and prognosis, chemotherapy resistance is a major hurdle in the battle against breast cancer. Identifying predictive…”
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Differential outcome of infection with attenuated Salmonella in MyD88-deficient mice is dependent on the route of administration
Published in Immunobiology (1979) (01-01-2013)“…Abstract Activation of the innate immune system is a prerequisite for the induction of adaptive immunity to both infectious and non-infectious agents. TLRs are…”
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Role of acetylcholine receptors in cholinergic pathway-mediated protection against autoimmune diabetes
Published in The Journal of immunology (1950) (01-05-2019)“…Abstract Type I diabetes (T1D) is a T cell-driven autoimmune disease that results in the killing of pancreatic β-cells and, consequently, loss of insulin…”
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Obesity promotes cancer growth by enhancing the suppressive activity of intratumoral myeloid cells
Published in The Journal of immunology (1950) (01-05-2017)“…Abstract Epidemiological evidence suggests that obesity is linked to increased risk of developing several types of cancer. However, the mechanisms underlying…”
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Cholinergic stimulation enhances intestinal antimicrobial activity and prevents systemic dissemination of pathogenic bacteria
Published in The Journal of immunology (1950) (01-05-2017)“…Abstract Inflammation constitutes an important component of host defense against pathogenic bacteria. This innate immune response is crucial for clearance of…”
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