Search Results - "MOGG, Robin"

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy by Cristescu, Razvan, Mogg, Robin, Ayers, Mark, Albright, Andrew, Murphy, Erin, Yearley, Jennifer, Sher, Xinwei, Liu, Xiao Qiao, Lu, Hongchao, Nebozhyn, Michael, Zhang, Chunsheng, Lunceford, Jared K, Joe, Andrew, Cheng, Jonathan, Webber, Andrea L, Ibrahim, Nageatte, Plimack, Elizabeth R, Ott, Patrick A, Seiwert, Tanguy Y, Ribas, Antoni, McClanahan, Terrill K, Tomassini, Joanne E, Loboda, Andrey, Kaufman, David

“…Programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) checkpoint blockade immunotherapy elicits durable antitumor effects in…”
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Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial by Buchbinder, Susan P, MD, Mehrotra, Devan V, PhD, Duerr, Ann, MD, Fitzgerald, Daniel W, MD, Mogg, Robin, MS, Li, David, PhD, Gilbert, Peter B, Prof, Lama, Javier R, MD, Marmor, Michael, Prof, del Rio, Carlos, Prof, McElrath, M Juliana, Prof, Casimiro, Danilo R, PhD, Gottesdiener, Keith M, MD, Chodakewitz, Jeffrey A, MD, Corey, Lawrence, Prof, Robertson, Michael N, MD

“…Summary Background Observational data and non-human primate challenge studies suggest that cell-mediated immune responses might provide control of HIV…”
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Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma by Haddad, Robert I, Seiwert, Tanguy Y, Chow, Laura Q M, Gupta, Shilpa, Weiss, Jared, Gluck, Iris, Eder, Joseph P, Burtness, Barbara, Tahara, Makoto, Keam, Bhumsuk, Kang, Hyunseok, Muro, Kei, Albright, Andrew, Mogg, Robin, Ayers, Mark, Huang, Lingkang, Lunceford, Jared, Cristescu, Razvan, Cheng, Jonathan, Mehra, Ranee

“…BackgroundTo characterize genomic determinants of response to pembrolizumab in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) in the…”
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Safety, tolerability, and pharmacokinetics of single‐ and multiple‐dose administration of islatravir (MK‐8591) in adults without HIV by Matthews, Randolph P., Ankrom, Wendy, Friedman, Evan, Jackson Rudd, Deanne, Liu, Yang, Mogg, Robin, Panebianco, Deborah, De Lepeleire, Inge, Petkova, Magdalena, Grobler, Jay A., Stoch, Selwyn Aubrey, Iwamoto, Marian

“…Islatravir (MK‐8591) is a nucleoside analogue in development for the treatment and prevention of HIV‐1. Two phase 1 trials were conducted during initial…”
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A template for the authoring of statistical analysis plans by Stevens, Gary, Dolley, Shawn, Mogg, Robin, Connor, Jason T.

“…A number of principal investigators may have limited access to biostatisticians, a lack of biostatistical training, or no requirement to complete a timely…”
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Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial by Dushianthan, Ahilanandan, Clark, Howard, Madsen, Jens, Mogg, Robin, Matthews, Lewis, Berry, Lee, de la Serna, Jorge Bernardino, Batchelor, James, Brealey, David, Hussell, Tracy, Porter, Joanna, Djukanovic, Ratko, Feelisch, Martin, Postle, Anthony, Grocott, Michael P W

“…SARS-Cov-2 virus preferentially binds to the Angiotensin Converting Enzyme 2 (ACE2) on alveolar epithelial type II cells, initiating an inflammatory response…”
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Biomarkers predictive of response to pembrolizumab in head and neck cancer by Pfister, David G., Haddad, Robert I., Worden, Francis P., Weiss, Jared, Mehra, Ranee, Chow, Laura Q. M., Liu, Stephen V., Kang, Hyunseok, Saba, Nabil F., Wirth, Lori J., Sukari, Ammar, Massarelli, Erminia, Ayers, Mark, Albright, Andrew, Webber, Andrea L., Mogg, Robin, Lunceford, Jared, Huang, Lingkang, Cristescu, Razvan, Cheng, Jonathan, Seiwert, Tanguy Y., Bauml, Joshua M.

“…Background We performed an integrated biomarker evaluation in pembrolizumab‐treated patients with R/M HNSCC enrolled in KEYNOTE‐012 or KEYNOTE‐055. The…”
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End-point definition and trial design to advance tuberculosis vaccine development by Garcia-Basteiro, Alberto L, White, Richard G, Tait, Dereck, Schmidt, Alexander C, Rangaka, Molebogeng X, Quaife, Matthew, Nemes, Elisa, Mogg, Robin, Hill, Philip C, Harris, Rebecca C, Hanekom, Willem A, Frick, Mike, Fiore-Gartland, Andrew, Evans, Tom, Dagnew, Alemnew F, Churchyard, Gavin, Cobelens, Frank, Behr, Marcel A, Hatherill, Mark

“…Tuberculosis (TB) remains a leading infectious cause of death worldwide and the coronavirus disease 2019 pandemic has negatively impacted the global TB burden…”
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Genomic determinants of response to pembrolizumab in head and neck squamous cell carcinoma (HNSCC) by Haddad, Robert I., Seiwert, Tanguy Y., Chow, Laura Quan Man, Gupta, Shilpa, Weiss, Jared, Gluck, Iris, Eder, Joseph Paul, Burtness, Barbara, Tahara, Makoto, Keam, Bhumsuk, Kang, Hyunseok, Muro, Kei, Albright, Andrew, Huang, Lingkang, Ayers, Mark, Mogg, Robin, Cristescu, Razvan, Cheng, Jonathan D., Mehra, Ranee

“…Abstract only 6009 Background: Somatic mutational load (ML) is associated with response to anti CTLA-4 and PD-1/-L1 immunotherapies in select tumors, due to…”
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Tolerability of Two Sequential Electroporation Treatments Using MedPulser DNA Delivery System (DDS) in Healthy Adults by Wallace, Mark, Evans, Barbara, Woods, Sandra, Mogg, Robin, Zhang, Lei, Finnefrock, Adam C, Rabussay, Dietmar, Fons, Michael, Mallee, John, Mehrotra, Devan, Schödel, Florian, Musey, Luwy

“…Immunotherapy against infectious agents and malignant tumors requires efficient priming of effector cells through direct expression and/or efficient…”
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Pharmacogenetic analysis of OATP1B1 variants in relation to the pharmacokinetics of Grazoprevir and the efficacy of Zepatier (Elbasvir and Grazoprevir) in HCV infected subjects from previously conducted clinical studies by Guo, Zifang, Caro, Luzelena, Robertson, Michael N., Mccrea, Jacqueline, Hoover, Patricia, Wudarski, Christen, Maiuri, Kristina, Wang, Ying-Hong, Mogg, Robin, Mehrotra, Devan, Blanchard, Rebecca, Shaw, Peter M.

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Intensification of Statin Therapy Results in a Rapid Reduction in Atherosclerotic Inflammation by Tawakol, Ahmed, MD, Fayad, Zahi A., PhD, Mogg, Robin, PhD, Alon, Achilles, PharmD, Klimas, Michael T., PhD, Dansky, Hayes, MD, Subramanian, Sharath S., MD, Abdelbaky, Amr, MD, Rudd, James H.F., MD, PhD, Farkouh, Michael E., MD, MSc, Nunes, Irene O., PhD, Beals, Chan R., MD, Shankar, Sudha S., MD

“…Objectives The study sought to test whether high-dose statin treatment would result in greater reductions in plaque inflammation than low-dose statins, using…”
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Detection of HIV Vaccine-Induced Cell-Mediated Immunity in HIV-Seronegative Clinical Trial Participants Using an Optimized and Validated Enzyme-Linked Immunospot Assay by Dubey, Sheri, Clair, James, Fu, Tong-Ming, Guan, Liming, Long, Romnie, Mogg, Robin, Anderson, Kiersten, Collins, Kelly B, Gaunt, Christine, Fernandez, V Rose, Zhu, Lan, Kierstead, Lisa, Thaler, Scott, Gupta, Swati B, Straus, Walter, Mehrotra, Devan, Tobery, Timothy W, Casimiro, Danilo R, Shiver, John W

“…An effective vaccine for HIV is likely to require induction of T-cell-mediated immune responses, and the interferon-γ (IFNγ) enzyme-linked immunospot (ELISPOT)…”
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Randomized Study of Rivaroxaban vs Placebo on Disease Progression and Symptoms Resolution in High-Risk Adults With Mild Coronavirus Disease 2019 by Ananworanich, Jintanat, Mogg, Robin, Dunne, Michael W, Bassyouni, Mohamed, David, Consuela Vera, Gonzalez, Erika, Rogalski-Salter, Taryn, Shih, Heather, Silverman, Jared, Medema, Jeroen, Heaton, Penny

“…Abstract Background Severe acute respiratory syndrome coronavirus 2 infection may be associated with a prothrombotic state, predisposing patients for a…”
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Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study by Giaccone, Giuseppe, Kim, Chul, Thompson, Jillian, McGuire, Colleen, Kallakury, Bhaskar, Chahine, Joeffrey J, Manning, Maria, Mogg, Robin, Blumenschein, Wendy M, Tan, Ming T, Subramaniam, Deepa S, Liu, Stephen V, Kaplan, Ian M, McCutcheon, Justine N

“…Treatment options are limited for patients with thymic carcinoma. These aggressive tumours are not typically associated with paraneoplastic autoimmune…”
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A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma by Huang, Alexander C., Orlowski, Robert J., Xu, Xiaowei, Mick, Rosemarie, George, Sangeeth M., Yan, Patrick K., Manne, Sasikanth, Kraya, Adam A., Wubbenhorst, Bradley, Dorfman, Liza, D’Andrea, Kurt, Wenz, Brandon M., Liu, Shujing, Chilukuri, Lakshmi, Kozlov, Andrew, Carberry, Mary, Giles, Lydia, Kier, Melanie W., Quagliarello, Felix, McGettigan, Suzanne, Kreider, Kristin, Annamalai, Lakshmanan, Zhao, Qing, Mogg, Robin, Xu, Wei, Blumenschein, Wendy M., Yearley, Jennifer H., Linette, Gerald P., Amaravadi, Ravi K., Schuchter, Lynn M., Herati, Ramin S., Bengsch, Bertram, Nathanson, Katherine L., Farwell, Michael D., Karakousis, Giorgos C., Wherry, E. John, Mitchell, Tara C.

“…Immunologic responses to anti-PD-1 therapy in melanoma patients occur rapidly with pharmacodynamic T cell responses detectable in blood by 3 weeks. It is…”
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Intensification of Statin Therapy Results in a Rapid Reduction in Atherosclerotic Inflammation: Results of a Multicenter Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Feasibility Study by TAWAKOL, Ahmed, FAYAD, Zahi A, NUNES, Irene O, BEALS, Chan R, SHANKAR, Sudha S, MOGG, Robin, ALON, Achilles, KLIMAS, Michael T, DANSKY, Hayes, SUBRAMANIAN, Sharath S, ABDELBAKY, Amr, RUDD, James H. F, FARKOUH, Michael E

“…The study sought to test whether high-dose statin treatment would result in greater reductions in plaque inflammation than low-dose statins, using…”
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How COVID-19 has fundamentally changed clinical research in global health by Park, Jay J H, Mogg, Robin, Smith, Gerald E, Nakimuli-Mpungu, Etheldreda, Jehan, Fyezah, Rayner, Craig R, Condo, Jeanine, Decloedt, Eric H, Nachega, Jean B, Reis, Gilmar, Mills, Edward J

“…COVID-19 has had negative repercussions on the entire global population. Despite there being a common goal that should have unified resources and efforts,…”
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Should baseline be a covariate or dependent variable in analyses of change from baseline in clinical trials? by Liu, Guanghan F., Lu, Kaifeng, Mogg, Robin, Mallick, Madhuja, Mehrotra, Devan V.

“…In randomized clinical trials, a pre‐treatment measurement is often taken at baseline, and post‐treatment effects are measured at several time points…”
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Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition With Pembrolizumab Outcomes in Advanced Melanoma: Pooled Analysis of 3 Clinical Trials by Puzanov, Igor, Ribas, Antoni, Robert, Caroline, Schachter, Jacob, Nyakas, Marta, Daud, Adil, Arance, Ana, Carlino, Matteo S, O'Day, Steven J, Long, Georgina V, Margolin, Kim A, Dummer, Reinhard, Schadendorf, Dirk, Lutzky, Jose, Ascierto, Paolo A, Tarhini, Ahmad, Lin, Jianxin, Mogg, Robin, Homet Moreno, Blanca, Ibrahim, Nageatte, Hamid, Omid

“…The optimal sequencing of immune checkpoint inhibitors and targeted therapy for BRAF V600E/K-mutant melanoma is not well established. To assess the association…”
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