Search Results - "MOERLAND, Perry D"

MiR423-5p As a Circulating Biomarker for Heart Failure by Tijsen, Anke J, Creemers, Esther E, Moerland, Perry D, de Windt, Leon J, van der Wal, Allard C, Kok, Wouter E, Pinto, Yigal M

“…RATIONALE:Aberrant expression profiles of circulating microRNAs (miRNAs) have been described in various diseases and provide high sensitivity and specificity…”
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A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways by Molenaars, Marte, Janssens, Georges E., Williams, Evan G., Jongejan, Aldo, Lan, Jiayi, Rabot, Sylvie, Joly, Fatima, Moerland, Perry D., Schomakers, Bauke V., Lezzerini, Marco, Liu, Yasmine J., McCormick, Mark A., Kennedy, Brian K., van Weeghel, Michel, van Kampen, Antoine H.C., Aebersold, Ruedi, MacInnes, Alyson W., Houtkooper, Riekelt H.

“…Slowing down translation in either the cytosol or the mitochondria is a conserved longevity mechanism. Here, we found a non-interventional natural correlation…”
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Study Design and qPCR Data Analysis Guidelines for Reliable Circulating miRNA Biomarker Experiments: A Review by de Ronde, Maurice W J, Ruijter, Jan M, Moerland, Perry D, Creemers, Esther E, Pinto-Sietsma, Sara-Joan

“…In the past decade, the search for circulating microRNA (miRNA) biomarkers has yielded numerous associations between miRNAs and different types of disease…”
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Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation by van den Bosch, Aletta M. R., van der Poel, Marlijn, Fransen, Nina L., Vincenten, Maria C. J., Bobeldijk, Anneleen M., Jongejan, Aldo, Engelenburg, Hendrik J., Moerland, Perry D., Smolders, Joost, Huitinga, Inge, Hamann, Jörg

“…Microglia nodules (HLA-DR + cell clusters) are associated with brain pathology. In this post-mortem study, we investigated whether they represent the first…”
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Normalization panels for the reliable quantification of circulating microRNAs by RT‐qPCR by Kok, Maayke G. M., Halliani, Amalia, Moerland, Perry D., Meijers, Joost C. M., Creemers, Esther E., Pinto‐Sietsma, Sara‐Joan

“…ABSTRACT Circulating microRNAs (miRNAs) have been reported as biomarkers for disease diagnosis. RT‐qPCR is most commonly used to detect miRNAs; however, no…”
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ENCORE: a practical implementation to improve reproducibility and transparency of computational research by van Kampen, Antoine H. C., Mahamune, Utkarsh, Jongejan, Aldo, van Schaik, Barbera D. C., Balashova, Daria, Lashgari, Danial, Pras-Raves, Mia, Wever, Eric J. M., Dane, Adrie D., García-Valiente, Rodrigo, Moerland, Perry D.

“…Reproducibility of computational research is often challenging despite established guidelines and best practices. Translating these guidelines into practical…”
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The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans by van der Meer, Anne J, Scicluna, Brendon P, Moerland, Perry D, Lin, Jiang, Jacobson, Eric W, Vlasuk, George P, van der Poll, Tom

“…Sirtuin 1 influences gene expression and other cellular functions through deacetylation of histone and nonhistone proteins. We here sought to determine the…”
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Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis by Kleinrouweler, C Emily, van Uitert, Miranda, Moerland, Perry D, Ris-Stalpers, Carrie, van der Post, Joris A M, Afink, Gijs B

“…To systematically review the literature on human gene expression data of placental tissue in pre-eclampsia and to characterize a meta-signature of…”
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Large Expression Differences in Genes for Iron and Zinc Homeostasis, Stress Response, and Lignin Biosynthesis Distinguish Roots of Arabidopsis thaliana and the Related Metal Hyperaccumulator Thlaspi caerulescens by van de Mortel, Judith E., Villanueva, Laia Almar, Schat, Henk, Kwekkeboom, Jeroen, Coughlan, Sean, Moerland, Perry D., van Themaat, Emiel Ver Loren, Koornneef, Maarten, Aarts, Mark G. M.

“…The micronutrient zinc has an essential role in physiological and metabolic processes in plants as a cofactor or structural element in 300 catalytic and…”
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Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia by van Uitert, Miranda, Moerland, Perry D, Enquobahrie, Daniel A, Laivuori, Hannele, van der Post, Joris A M, Ris-Stalpers, Carrie, Afink, Gijs B

“…Studies using the placental transcriptome to identify key molecules relevant for preeclampsia are hampered by a relatively small sample size. In addition, they…”
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Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer by Soleimani Dodaran, Maryam, Borgoni, Simone, Sofyalı, Emre, Verschure, Pernette J, Wiemann, Stefan, Moerland, Perry D, van Kampen, Antoine H C

“…Estrogen receptor (ER) positive breast cancer is often effectively treated with drugs that inhibit ER signaling, i.e., tamoxifen (TAM) and aromatase inhibitors…”
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Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response by de Vries, Luuk E, Jongejan, Aldo, Monteiro Fortes, Jennifer, Balesar, Rawien, Rozemuller, Annemieke J M, Moerland, Perry D, Huitinga, Inge, Swaab, Dick F, Verhaagen, Joost

“…Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer's disease (AD). This phenomenon…”
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Comparative gene expression study and pathway analysis of the human iris- and the retinal pigment epithelium by Bennis, Anna, Ten Brink, Jacoline B, Moerland, Perry D, Heine, Vivi M, Bergen, Arthur A

“…The retinal pigment epithelium (RPE) is a neural monolayer lining the back of the eye. Degeneration of the RPE leads to severe vision loss in, so far…”
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The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model by van Hagen, Martijn, Piebes, Diewertje G E, de Leeuw, Wim C, Vuist, Ilona M, van Roon-Mom, Willeke M C, Moerland, Perry D, Verschure, Pernette J

“…Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the Huntingtin (HTT) gene. Proteolytic cleavage of mutant…”
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Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis by Duijvis, Nicolette W, Moerland, Perry D, Kunne, Cindy, Slaman, Monique M W, van Dooren, Faas H, Vogels, Esther W, de Jonge, Wouter J, Meijer, Sybren L, Fluiter, Kees, Te Velde, Anje A

“…MicroRNAs (miRNAs) are epigenetically involved in regulating gene expression. They may be of importance in the pathogenesis of inflammatory bowel disease…”
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Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis by Hsiao, Cheng-Chih, Engelenburg, Hendrik J., Jongejan, Aldo, Zhu, Jing, Zhang, Baohong, Mingueneau, Michael, Moerland, Perry D., Huitinga, Inge, Smolders, Joost, Hamann, Jörg

“…The human brain is populated by perivascular T cells with a tissue-resident memory T (TRM)-cell phenotype, which in multiple sclerosis (MS) associate with…”
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SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma by Leeksma, Alexander C., Derks, Ingrid A. M., Garrick, Brett, Jongejan, Aldo, Colombo, Martino, Bloedjes, Timon, Trowe, Torsten, Leisten, Jim C., Howarth, Michelle, Malek, Mehnaz, Mortensen, Deborah S., Blease, Kate, Groza, Mathew C., Narla, Rama Krishna, Loos, Remco, Kersten, Marie‐José, Moerland, Perry D., Guikema, Jeroen E. J., Kater, Arnon P., Eldering, Eric, Filvaroff, Ellen H.

“…Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein…”
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Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction by Lodder, Elisabeth M, Scicluna, Brendon P, Milano, Annalisa, Sun, Albert Y, Tang, Hao, Remme, Carol Ann, Moerland, Perry D, Tanck, Michael W T, Pitt, Geoffrey S, Marchuk, Douglas A, Bezzina, Connie R

“…Atrio-ventricular conduction disease is a common feature in Mendelian rhythm disorders associated with sudden cardiac death and is characterized by…”
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Notch controls the magnitude of T helper cell responses by promoting cellular longevity by Helbig, Christina, Gentek, Rebecca, Backer, Ronald A., de Souza, Yevan, Derks, Ingrid A. M., Eldering, Eric, Wagner, Koen, Jankovic, Dragana, Gridley, Thomas, Moerland, Perry D., Flavell, Richard A., Amsen, Derk

“…Generation of effective immune responses requires expansion of rare antigen-specific CD4⁺ T cells. The magnitude of the responding population is ultimately…”
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Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340 and miRNA624 by Sondermeijer, Brigitte M, Bakker, Annemieke, Halliani, Amalia, de Ronde, Maurice W J, Marquart, Arnoud A, Tijsen, Anke J, Mulders, Ties A, Kok, Maayke G M, Battjes, Suzanne, Maiwald, Steffi, Sivapalaratnam, Suthesh, Trip, Mieke D, Moerland, Perry D, Meijers, Joost C M, Creemers, Esther E, Pinto-Sietsma, Sara-Joan

“…Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies…”
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