ANTIBACTERIAL ACTIVITY OF CEFTAZIDIME
We studied in vitro and in vivo antibacterial activity of ceftazidime (CAZ, SN401) comparing with that of cefazolin, cefmetazole, cefotaxime, cefuroxime, cefoxitin, cefoperazone, latamoxef, cefsulodin and gentamicin, and obtained the following results. 1. CAZ showed broad spectrum and high antibacte...
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| Published in: | CHEMOTHERAPY Vol. 31; no. Supplement3; pp. 136 - 145 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | Japanese |
| Published: |
Japanese Society of Chemotherapy
25-10-1983
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| Online Access: | Get full text |
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| Summary: | We studied in vitro and in vivo antibacterial activity of ceftazidime (CAZ, SN401) comparing with that of cefazolin, cefmetazole, cefotaxime, cefuroxime, cefoxitin, cefoperazone, latamoxef, cefsulodin and gentamicin, and obtained the following results. 1. CAZ showed broad spectrum and high antibacterial activity against Gram-positive and negative bacteria. 2. In particular, it showed high antibacterial activity against Gram-negative bacteria, which was almost equivalent to that of cefotaxime, cefoperazone and latamoxef, and higher than that of these drugs against S. marcescens. 3) Antibacterial activity against P.aeruginosa was comparable to that of aminoglycoside antibiotics, higher than that of cefsulodin and cefoperazone which are anti-pseudomonal cephems. 4. CAZ was highly stable to β-lactamses produced by various Gram-negative bacteria. 5. The antibacterial activity of CAZ was bactericidal and which was little affected by kinds or pH of media, inoculum size, etc. 6. In a protection test in mice, excellent effects were obtained, reflecting the high in vitro antibacterial activity of CAZ. |
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| ISSN: | 0009-3165 1884-5894 |
| DOI: | 10.11250/chemotherapy1953.31.Supplement3_136 |