Search Results - "MOCAËR, E"

Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties by Guardiola‐Lemaitre, B, De Bodinat, C, Delagrange, P, Millan, M J, Munoz, C, Mocaër, E

“…Agomelatine behaves both as a potent agonist at melatonin MT1 and MT2 receptors and as a neutral antagonist at 5‐HT2C receptors. Accumulating evidence in a…”
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Repeated restraint stress-induced atrophy of glutamatergic pyramidal neurons and decreases in glutamatergic efflux in the rat amygdala are prevented by the antidepressant agomelatine by Grillo, C.A, Risher, M, Macht, V.A, Bumgardner, A.L, Hang, A, Gabriel, C, Mocaër, E, Piroli, G.G, Fadel, J.R, Reagan, L.P

“…Highlights • Repeated restraint stress (RRS) elicits atrophy of pyramidal neurons in the rat basolateral nucleus of the amygdala (CBL). • RRS decreases acute…”
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Better sexual acceptability of agomelatine (25 and 50 mg) compared with paroxetine (20 mg) in healthy male volunteers. An 8-week, placebo-controlled study using the PRSEXDQ-SALSEX scale by Montejo, AL, Prieto, N., Terleira, A., Matias, J., Alonso, S., Paniagua, G., Naval, S., Parra, DG, Gabriel, C., Mocaër, E., Portolés, A.

“…Sexual dysfunction (SD) is a common and underestimated effect of antidepressants. Healthy volunteers are the most adequate group to study this adverse event…”
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Agomelatine reverses cognition-related behavior and hippocampal gene expression alterations induced by chronic social defeat stress in mice by Martin, V, Allaïli, N, Euvrard, M, Marday, T, Franc, B, Gabriel, C, Mocaër, E, Fossati, P, Lehericy, S, Lanfumey, L

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P.1.h.006 Anti-allodynic effects of agomelatine combined with gabapentin in neuropathic rats with infraorbital nerve constriction by Bourgoin, S, Michot, B, Deraredj, N, de Laujardière, M. Bertrand, Gabriel, C, Mocaër, E, Hamon, M

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P.2.d.005 Agomelatine reduces long-term fear memory but not acquisition or short-term fear memories – involvement of melatonergic and 5-HT2C receptors by Mocaër, E, Diaz-Mataix, L, Seguin, L, Ledoux, J.E

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P.2.a.011 Chronic mild stress-induced behavioural and epigenetic changes in mice – prevention by agomelatine treatment by Boulle, F, Massart, R, Zaidan, L, Marday, S, Gabriel, C, Mocaër, E, Hamon, M, Lanfumey, L

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P.1.h.013 Agomelatine induces antihyperalgesic effects in a rat model of neuropathic pain and produces an additive interaction with gabapentin by Chenaf, C, Chapuy, E, Courteix, C, Libert, F, Laujardière, M. Bertrandde, Gabriel, C, Mocaër, E, Eschalier, A

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P.2.d.012 Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine by Molteni, R, Macchi, F, Zecchillo, C, Gabriel, C, Mocaër, E, Racagni, G, Riva, M.A

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P02-58 - The antidepressant agomelatine reduces fear long term memory but not acquisition or short term expression of fear memories by Diaz-Mataix, L, Mocaër, E, Seguin, L, Ledoux, J.E

“…Alterations in fear learning processes may be implicated in mood disorders. Fear learning has been investigated with Pavlovian classical fear conditioning…”
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Roles of 5-HT1A receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model by CERVO, L, MOCAËR, E, BERTAGLIA, A, SAMANIN, R

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P02-57 - Chronic agomelatine administration modulates neuronal plasticity markers in the rat prefrontal cortex, hippocampus and amygdala by Ladurelle, N, Potard, C, Gabriel-Gracia, C, Mocaër, E, Beaulieu, E, Bianchi, M

“…Neuronal plasticity alterations including cytoskeletal dynamics and synaptic markers have been recently associated with the treatment of major depression. Here…”
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Circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light by Li, X. M., Beau, J., Delagrange, P., Mocaër, E., Lévi, F.

“…:  The ability of daily melatonin and the melatonin receptor antagonist, S22153, to entrain circadian system function was investigated in mice with atypical…”
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P.2.d.023 Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress by Mocaër, E, Dagyté, G, Crescente, I, Postema, F, Seguin, L, Gabriel, C, Den Boer, J.A, Koolhaas, J.M

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Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine by Boulle, F, Massart, R, Stragier, E, Païzanis, E, Zaidan, L, Marday, S, Gabriel, C, Mocaer, E, Mongeau, R, Lanfumey, L

“…Stress-induced alterations in neuronal plasticity and in hippocampal functions have been suggested to be involved in the development of mood disorders. In this…”
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P.2.c.028 Effect of a single dose (50 mg) of agomelatine on bold fMRI responses to face emotion recognition in healthy volunteers by Lees, J, McKie, S, Dadhiwala, R, Horgan, P, Dawson, G, Seguin, L, Mocaër, E, Deakin, J.F.W

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Somatodendritic 5-HT1A Autoreceptors Mediate the Anti-Aggressive Actions of 5-HT1A Receptor Agonists in Rats: An Ethopharmacological Study with S-15535, Alnespirone, and WAY-100635 by de Boer, Sietse F, Lesourd, Monique, Mocaër, Elisabeth, Koolhaas, Jaap M

“…To elucidate the relative contribution of somatodendritic 5-HT1A autoreceptors and postsynaptic 5-HT1A receptors in the specific anti-aggressive properties of…”
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Roles of 5-HT(1A) receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model by Cervo, L, Mocaër, E, Bertaglia, A, Samanin, R

“…8-OH-DPAT [8-hydroxy-2-(di-N-propylamino)tetralin], a 5-HT(1A) receptor agonist, and S 15535 (4-benzodioxan-5-yl)1-(indan-2-yl)piperazine, a partial agonist at…”
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Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice by Bretin, S., Krazem, A., Henkous, N., Froger-Colleaux, C., Mocaer, E., Louis, C., Perdaems, N., Marighetto, A., Beracochea, D.

“…Positive allosteric modulators of AMPA receptors (AMPA-PAMs) are described to facilitate cognitive processes in different memory-based models. Among them, S…”
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P.2.b.006 Effects of agomelatine and fluoxetine on hippocampal cell survival, glucocorticoid receptors and BDNF expression in a model of depression by Païzanis, E, Lelièvre, V, Saurini, F, Barden, N, Gabriel, C, Mocaër, E, Hamon, M, Lanfumey, L

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