Search Results - "MO, Ruowei"

Small-molecule WNK inhibition regulates cardiovascular and renal function by Yamada, Ken, Park, Hyi-Man, Rigel, Dean F, DiPetrillo, Keith, Whalen, Erin J, Anisowicz, Anthony, Beil, Michael, Berstler, James, Brocklehurst, Cara Emily, Burdick, Debra A, Caplan, Shari L, Capparelli, Michael P, Chen, Guanjing, Chen, Wei, Dale, Bethany, Deng, Lin, Fu, Fumin, Hamamatsu, Norio, Harasaki, Kouki, Herr, Tracey, Hoffmann, Peter, Hu, Qi-Ying, Huang, Waan-Jeng, Idamakanti, Neeraja, Imase, Hidetomo, Iwaki, Yuki, Jain, Monish, Jeyaseelan, Jey, Kato, Mitsunori, Kaushik, Virendar K, Kohls, Darcy, Kunjathoor, Vidya, LaSala, Daniel, Lee, Jongchan, Liu, Jing, Luo, Yang, Ma, Fupeng, Mo, Ruowei, Mowbray, Sarah, Mogi, Muneto, Ossola, Flavio, Pandey, Pramod, Patel, Sejal J, Raghavan, Swetha, Salem, Bahaa, Shanado, Yuka H, Trakshel, Gary M, Turner, Gordon, Wakai, Hiromichi, Wang, Chunhua, Weldon, Stephen, Wielicki, Jennifer B, Xie, Xiaoling, Xu, Lingfei, Yagi, Yukiko I, Yasoshima, Kayo, Yin, Jianning, Yowe, David, Zhang, Ji-Hu, Zheng, Gang, Monovich, Lauren

“…A selective inhibitor of the With-No-Lysine (K) (WNK) kinase family reduces blood pressure and increases electrolyte excretion in hypertensive rats. The…”
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γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists by Cherney, Robert J., Mo, Ruowei, Meyer, Dayton T., Voss, Matthew E., Yang, Michael G., Santella, Joseph B., Duncia, John V., Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Zhao, Qihong, Mandlekar, Sandhya, Cvijic, Mary Ellen, Barrish, Joel C., Decicco, Carl P., Carter, Percy H.

“…We describe the design, synthesis, and evaluation, of γ-lactams as glycinamide replacements within a series of di- and trisubstituted cyclohexane CCR2…”
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Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists by Cherney, Robert J., Mo, Ruowei, Meyer, Dayton T., Voss, Matthew E., Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Tebben, Andrew J., Carter, Percy H., Decicco, Carl P.

“…Potent sulfone-containing di- and trisubstituted cyclohexanes were synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the…”
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Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists by Cherney, Robert J., Brogan, John B., Mo, Ruowei, Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Molino, Bruce F., Carter, Percy H., Decicco, Carl P.

“…A series of trisubstituted cyclohexanes was designed, synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the identification…”
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Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore by MCNULTY, James, MAO, Justin, GIBE, Romelo, MO, Ruowei, WOLF, Sonja, PETTIT, George R, HERALD, Delbert L, BOYD, Michael R

“…Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were…”
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Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists by Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Nelson, David J, Lo, Yvonne C, Yang, Gengjie, Scherle, Peggy A, Mandlekar, Sandhya, Wasserman, Zelda R, Jezak, Heather, Solomon, Kimberly A, Tebben, Andrew J, Carter, Percy H, Decicco, Carl P

“…We describe the design, synthesis, and evaluation of novel disubstituted cyclohexanes as potent CCR2 antagonists. Exploratory SAR studies led to the…”
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Merging Biocatalysis, Flow, and Surfactant Chemistry: Innovative Synthesis of an FXI (Factor XI) Inhibitor by Wu, Bin, Zhang, Sisi, Hong, Tao, Zhou, Yizong, Wang, Hui, Shi, Min, Yang, Hongwei, Tian, Xiangguang, Guo, Jing, Bian, Jianwei, Roache, James, Delgado, Pete, Mo, Ruowei, Fridrich, Cary, Gao, Feng, Wang, Jianhua

“…The scalable synthesis of an FXI (Factor XI) inhibitor employing multiple emerging technologies is described. The reduction of ketone to chiral alcohol was…”
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Discovery of a brain-sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation by Peukert, Stefan, Gulgeze Efthymiou, Hatice Belgin, Mo, Ruowei, Peng, Yunshan, Ma, Fupeng, Barbe, Guillaume, Bebernitz, Gregory, Fridrich, Cary, Buono, Chiara, Williams, Eric T., Daniels, Thomas, Li, Lisha, Zhang, Xia, Adachi, Yuichiro, Abe, Mie, Taggart, Andrew K.P.

“…[Display omitted] Atrial fibrillation (AF) is the most common cardiac arrhythmia, and a significant risk factor for ischemic stroke and heart failure. Marketed…”
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Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672 by Yang, Michael G, Xiao, Zili, Cherney, Robert J, Tebben, Andrew J, Batt, Douglas G, Brown, Gregory D, Chen, Jing, Cvijic, Mary Ellen, Dabros, Marta, Duncia, John V, Galella, Michael, Gardner, Daniel S, Khandelwal, Purnima, Ko, Soo S, Malley, Mary F, Mo, Ruowei, Pang, Jian, Rose, Anne V, Santella, Joseph B, Shi, Hong, Srivastava, Anurag, Traeger, Sarah C, Wang, Bei, Xu, Songmei, Zhao, Rulin, Barrish, Joel C, Mandlekar, Sandhya, Zhao, Qihong, Carter, Percy H

“…We encountered a dilemma in the course of studying a series of antagonists of the G-protein coupled receptor CC chemokine receptor-2 (CCR2): compounds with…”
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Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists by Cherney, Robert J., Mo, Ruowei, Yang, Michael G., Xiao, Zili, Zhao, Qihong, Mandlekar, Sandhya, Cvijic, Mary Ellen, Charo, Israel F., Barrish, Joel C., Decicco, Carl P., Carter, Percy H.

“…We describe novel alkylsulfones as potent CCR2 antagonists with reduced hERG channel activity and improved pharmacokinetics over our previously described…”
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Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5 by Carter, Percy H, Brown, Gregory D, Cherney, Robert J, Batt, Douglas G, Chen, Jing, Clark, Cheryl M, Cvijic, Mary Ellen, Duncia, John V, Ko, Soo S, Mandlekar, Sandhya, Mo, Ruowei, Nelson, David J, Pang, Jian, Rose, Anne V, Santella, Joseph B, Tebben, Andrew J, Traeger, Sarah C, Xu, Songmei, Zhao, Qihong, Barrish, Joel C

“…We describe the hybridization of our previously reported acyclic and cyclic CC chemokine receptor 2 (CCR2) antagonists to lead to a new series of dual…”
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Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists by Cherney, Robert J., Mo, Ruowei, Meyer, Dayton T., Pechulis, Anthony D., Guaciaro, Michael A., Lo, Yvonne C., Yang, Gengjie, Miller, Persymphonie B., Scherle, Peggy A., Zhao, Qihong, Cvijic, Mary Ellen, Barrish, Joel C., Decicco, Carl P., Carter, Percy H.

“…We describe the design, synthesis, and evaluation of benzimidazoles as benzamide replacements within a series of trisubstituted cyclohexane CCR2 antagonists…”
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Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2) by Yang, Michael G., Xiao, Zili, Shi, Qing, Cherney, Robert J., Tebben, Andrew J., De Lucca, George V., Santella, Joseph B., Mo, Ruowei, Cvijic, Mary Ellen, Zhao, Qihong, Barrish, Joel C., Carter, Percy H.

“…We report the synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamides (4) as CCR2 inhibitors for the potential treatment of inflammatory diseases…”
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g-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists by Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Voss, Matthew E, Yang, Michael G, Santella, Joseph B, Duncia, John V, Lo, Yvonne C, Yang, Gengjie, Miller, Persymphonie B, Scherle, Peggy A, Zhao, Qihong, Mandlekar, Sandhya, Cvijic, Mary Ellen, Barrish, Joel C, Decicco, Carl P, Carter, Percy H

“…We describe the design, synthesis, and evaluation, of g-lactams as glycinamide replacements within a series of di- and trisubstituted cyclohexane CCR2…”
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Potent and selective aggrecanase inhibitors containing cyclic P1 substituents by Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Wang, Li, Yao, Wenqing, Wasserman, Zelda R, Liu, Rui-Qin, Covington, Maryanne B, Tortorella, Micky D, Arner, Elizabeth C, Qian, Mingxin, Christ, David D, Trzaskos, James M, Newton, Robert C, Magolda, Ron L, Decicco, Carl P

“…Anti-succinate hydroxamates with cyclic P1 motifs were synthesized as aggrecanase inhibitors. The N-methanesulfonyl piperidine 23 and the N-trifluoroacetyl…”
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Sultam Hydroxamates as Novel Matrix Metalloproteinase Inhibitors by Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Hardman, Karl D, Liu, Rui-Qin, Covington, Maryanne B, Qian, Mingxin, Wasserman, Zelda R, Christ, David D, Trzaskos, James M, Newton, Robert C, Decicco, Carl P

“…In this communication we describe the design, synthesis, and evaluation of novel sultam hydroxamates 4 as MMP-2, -9, and -13 inhibitors. Compound 26 was found…”
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