Search Results - "MIZOJIRI, KENJI"

Drug-protein binding and blood-brain barrier permeability by Tanaka, H, Mizojiri, K

“…The permeability surface area (PS) product, an index of permeability of the blood-brain barrier (BBB), was measured by using the in situ perfusion method. In…”
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Separate Assessment of Intestinal and Hepatic First-pass Effects Using a Rat Model with Double Cannulation of the Portal and Jugular Veins by Murakami, Tsuyoshi, Nakanishi, Machiko, Yoshimori, Takeo, Okamura, Noboru, Norikura, Ryo, Mizojiri, Kenji

“…To separately assess intestinal and hepatic first-pass effects with absorption ratio data, we have established an experimental model of rats double-cannulated…”
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High resolution localization of endothelin receptors in rat renal medulla by Yukimura, Tokihito, Notoya, Mitsuru, Mizojiri, Kenji, Mizuhira, Vinci, Matsuura, Takeshi, Ebara, Tsuneyuki, Miura, Katsuyuki, Kim, Shokei, Iwao, Hiroshi, Song, Keifu

“…High resolution localization of endothelin receptors in rat renal medulla. The cellular localization of endothelin receptors in the inner medulla of the rat…”
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Separate Assessment of Intestinal and Hepatic First-pass Effects Using a Rat Model with Double Cannulation of the Portal and Jugular Veins by Tsuyoshi MURAKAMI, Machiko NAKANISHI, Takeo YOSHIMORI, Noboru OKAMURA, Ryo NORIKURA, Kenji MIZOJIRI

“…To separately assess intestinal and hepatic first-pass effects with absorption ratio data, we have established an experimental model of rats double-cannulated…”
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The possibility of predicting tissue accumulation after repeated dosing using a single-dose tissue distribution study by Mizojiri, K, Shindo, H, Ohno, Y

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Autoradiographic Studies on the Binding Sites of 125I-Adrenomedullin in Rat Tissues by Hasegawa, Hiroshi, Mizuhira, Vinci, Notoya, Mitsuru, Inazawa, Kazuhiro, Mizojiri, Kenji, Kitamura, Kazuo, Eto, Tanenao, Kangawa, Kenji

“…Adrenomedullin (AM) is a novel hypotensive peptide isolated from the human pheochromocytoma. In the present study, 125I-AM was intravenously administered to…”
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Estimation of Drug Accumulation in Repeated-Dose Tissue Distribution Studies by MIZOJIRI, Kenji, NORIKURA, Ryo

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Effects of Lisinopril on the Structure of Renal Arterioles by Notoya, Mitsuru, Nakamura, Masuhisa, Mizojiri, Kenji

“…We investigated the effect of long-term administration of the angiotensin-converting enzyme inhibitor lisinopril on renal arterioles in spontaneously…”
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Localization of endothelin receptors in rat renal medulla by Yukimura, Tokihito, Notoya, Mitsuru, Mizojiri, Kenji, Matsuura, Takeshi, Ebara, Tsuneyuki, Miura, Katsuyuki, Kim, Shokei, Iwao, Hiroshi

“…The cellular localization of endothelin receptors in the cortex and inner medulla of the rat kidney was studied by using light and electron microscopic…”
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Gastric Emptying Rate Constants after Oral Administration of Drug Solution to Mice, Rats, and Rabbits by WATANABE, JUN, OKABE, HIROSHI, ICHIHASHI, TERUHISA, MIZOJIRI, KENJI, YAMADA, HIDEO, YAMAMOTO, RYUICHI

“…Gastric emptying rates of quinine and phenol red were investigated after oral administration of the syrup or the simple solution to mice, rats, and rabbits…”
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Isolation of Perisoxal Glucuronides and Determination of Enantiomeric Ratios of d-and l-Perisoxal Metabolites excreted in Rabbit Urine by MIZOJIRI, KENJI, YAMAMOTO, ETSUKO, NAKAJIMA, YOSHITSUGU, OKABE, HIROSHI, SUGENO, KOICHI, WATANABE, JUN

“…Perisoxal glucuronides were isolated from rabbit urine after repeated subcutaneous administration of dl-perisoxal citrate. Optical rotatory analysis of free…”
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Determination of Perisoxal and Its Phenolic Metabolites in Rat, Rabbit and Human Urine by MIZOJIRI, KENJI, YAMAMOTO, ETSUKO, NAKAJIMA, YOSHITSUGU, OKABE, HIROSHI, SUGENO, KOICHI, WATANABE, JUN

“…After a single administration of perisoxal citrate to rats (21 mg/kg, i. v.), rabbits (15 mg/kg, i. v.) and humans (200 mg/man, p. o.), urinary excretion of…”
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Absorption, Excretion, Distribution and Metabolism of Perisoxal in Rats by WATANABE, JUN, OKABE, HIROSHI, MIZOJIRI, KENJI, NAKAJIMA, YOSHITSUGU, SUGENO, KOICHI, YAMAMOTO, RYUICHI

“…The drug was well absorbed from the intestinal tract, and the bulk of it was excreted in the urine and feces. Biliary excretion was significant, and the…”
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DISPOSITION OF 7432-8 IN RATS (I) by MIZOJIRI, KENJI, TAKASHIMA, AKIRA, YUKAWA, TADAHIKO, NAKANO, MASAYUKI

“…The absorption, excretion and metabolism of 7432-S were studied in male and female rats using 14C-labeled compound. 14C-7432-S, dissolved in phosphate buffer…”
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STUDIES ON ABSORPTION, DISTRIBUTION, BIOTRANSFORMATION AND EXCRETION OF CEFACLOR: THE THIRD REPORT: BIOTRANSFORMATION OF CEFACLOR IN VARIOUS KINDS OF EXPERIMENTAL ANIMALS by SUGENO, KOICHI, MIZOJIRI, KENJI, KAWAHARA, SEIICHI

“…14C-labeled cefaclor (14C-CCL) at 50 mg/kg was orally administered to study its absorption, excretion and biotransformation in mice, rats, rabbits, dog and…”
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Disposition of S-1108, a new oral cefem antibiotic, in experimental animals (1) blood concentration and excretion of radioactivity after oral administration of [7-14C]:-S-1108 to rats and dogs by Mizojiri, Kenji, Norikura, Ryo, Yoshimori, Takeo, Sugeno, Koichi, Esumi, Yoshio, Takaichi, Matsuo, Sasaki, Naoko, Yokota, Takashi

“…The absorption, excretion and metabolism of S-1108, an ester-type prodrug of S-1006, have been examined in rats and dogs by administering 14C-labeled S-1108 or…”
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Studies on theMetabolic Fate of Mometasone furoate(MF). (II). Absorption, Distribution, Excretion after Subcutaneous Administration to Rats and Rabbits by SUGENO, Koichi, MIZOJIRI, Kenji, Esumi, Yoshio, TAKAICHI, Matsuo, MIYAKE, Takayuki, SEKI, Hideaki

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Studies on the Metabolic Fate of Mometasone furoate (MF). (1). Percutaneous Absorption, Distribution, Excretion after Topical Application to Rats and Rabbits by SUGENO, Koichi, MIZOJIRI, Kenji, ESUMI, Yoshio, TAKAICHI, Matsuo, MIYAKE, Takayuki, SEKI, Hideaki

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Interaction of Some Pharmaceuticals with Synthetic Macromolecules. III. : Studies on the Binding of Several Pharmaceuticals with Styrene-Maleic Anhydride Copolymer by SHIMA, KAZUHIRO, MIZOJIRI, KENJI, ICHIHASHI, SETSUKO, YAMAMOTO, RYUICHI

“…In the previous papers of this series, the binding tendency of styrene-maleic anhydride copolymer (SMA) with certain pharmaceuticals was discussed. In this…”
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DISPOSITION OF 6315-S (FLOMOXEF) IN RATS (I) by MIZOJIRI, KENJI, OKABE, HIROSHI, TANAKA, HIDEO, SUGENO, KOICHI

“…The distribution, metabolism and excretion of 6315-S (flomoxef) were studied in male rats using two kinds of 14C-labeled compounds (7-14C-6315-S and…”
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