Search Results - "MIYATSUKA, Takeshi"

Chronology of endocrine differentiation and beta-cell neogenesis [Review] by Miyatsuka, Takeshi

“…Diabetes is a chronic and incurable disease, which results from absolute or relative insulin insufficiency. Therefore, pancreatic beta cells, which are the…”
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Heterogeneity of Islet Cells during Embryogenesis and Differentiation by Sasaki, Shugo, Miyatsuka, Takeshi

“…Diabetes is caused by insufficient insulin secretion due to β-cell dysfunction and/or β-cell loss. Therefore, the restoration of functional β-cells by the…”
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Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis by Osonoi, Yusuke, Mita, Tomoya, Azuma, Kosuke, Nakajima, Kenichi, Masuyama, Atsushi, Goto, Hiromasa, Nishida, Yuya, Miyatsuka, Takeshi, Fujitani, Yoshio, Koike, Masato, Mitsumata, Masako, Watada, Hirotaka

“…Macroautophagy/autophagy is considered as an evolutionarily conserved cellular catabolic process. In this study, we aimed to elucidate the role of autophagy in…”
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Golgi membrane-associated degradation pathway in yeast and mammals by Yamaguchi, Hirofumi, Arakawa, Satoko, Kanaseki, Toku, Miyatsuka, Takeshi, Fujitani, Yoshio, Watada, Hirotaka, Tsujimoto, Yoshihide, Shimizu, Shigeomi

“…Autophagy is a cellular process that degrades subcellular constituents, and is conserved from yeast to mammals. Although autophagy is believed to be essential…”
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Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system by Sasaki, Shugo, Lee, Michelle Y. Y., Wakabayashi, Yuka, Suzuki, Luka, Winata, Helena, Himuro, Miwa, Matsuoka, Taka-aki, Shimomura, Iichiro, Watada, Hirotaka, Lynn, Francis C., Miyatsuka, Takeshi

“…Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine progenitors in ductal regions, it remains unclear precisely where beta…”
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Prolonged impacts of sodium glucose cotransporter-2 inhibitors on metabolic dysfunction-associated steatotic liver disease in type 2 diabetes: a retrospective analysis through magnetic resonance imaging by Suzuki, Agena, Hayashi, Akinori, Oda, Satoshi, Fujishima, Rei, Shimizu, Naoya, Matoba, Kenta, Taguchi, Tomomi, Toki, Takuya, Miyatsuka, Takeshi

“…The beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in people with type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic…”
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Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice by Fukaishi, Takahiro, Nakagawa, Yuko, Fukunaka, Ayako, Sato, Takashi, Hara, Akemi, Nakao, Keiko, Saito, Michiko, Kohno, Kenji, Miyatsuka, Takeshi, Tamaki, Motoyuki, Matsuhisa, Munehide, Matsuoka, Taka-aki, Yamada, Tetsuya, Watada, Hirotaka, Fujitani, Yoshio

“…Aims/hypothesis Pancreatic polypeptide (PP) cells, which secrete PP (encoded by the Ppy gene), are a minor population of pancreatic endocrine cells. Although…”
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Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a by Miyatsuka, Takeshi, Kosaka, Yasuhiro, Kim, Hail, German, Michael S

“…During organogenesis, the final size of mature cell populations depends on their rates of differentiation and expansion. Because transient expression of…”
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Rubicon in pancreatic beta cells plays a limited role in maintaining glucose homeostasis following increased insulin resistance by Aoyama, Shuhei, Nishida, Yuya, Fujitani, Yoshio, Fukunaka, Ayako, Miyatsuka, Takeshi, Suzuki, Luka, Himuro, Miwa, Yoshimori, Tamotsu, Watada, Hirotaka

“…Autophagy has been reported to play a crucial role in the maintenance of intracellular homeostasis, including in pancreatic beta cells. Rubicon, which…”
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Effects of luseogliflozin on the secretion of islet hormones and incretins in patients with type 2 diabetes by Bando, Satoru, Ichikawa, Raishi, Taguchi, Tomomi, Fujimoto, Kazumi, Motomiya, Tetsuya, Taguchi, Madoka, Takano, Koji, Shichiri, Masayoshi, Miyatsuka, Takeshi

“…The insufficient activity of insulin and the hyperactivity of glucagon are responsible for glucose intolerance in patients with type 2 diabetes. Whereas…”
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Uncovering the mechanisms of beta-cell neogenesis and maturation toward development of a regenerative therapy for diabetes by Miyatsuka, Takeshi

“…Knowledge of the pathways involved in islet cell differentiation has been exploited to develop new methods for generating beta cells from non-beta cells, such…”
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Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression by Fukunaka, Ayako, Fukada, Toshiyuki, Bhin, Jinhyuk, Suzuki, Luka, Tsuzuki, Takamasa, Takamine, Yuri, Bin, Bum-Ho, Yoshihara, Toshinori, Ichinoseki-Sekine, Noriko, Naito, Hisashi, Miyatsuka, Takeshi, Takamiya, Shinzaburo, Sasaki, Tsutomu, Inagaki, Takeshi, Kitamura, Tadahiro, Kajimura, Shingo, Watada, Hirotaka, Fujitani, Yoshio

“…Given the relevance of beige adipocytes in adult humans, a better understanding of the molecular circuits involved in beige adipocyte biogenesis has provided…”
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Robust increase in glucagon secretion after oral protein intake, but not after glucose or lipid intake in Japanese people without diabetes by Ichikawa, Raishi, Takano, Koji, Fujimoto, Kazumi, Kobayashi, Masaki, Kitamura, Tadahiro, Shichiri, Masayoshi, Miyatsuka, Takeshi

“…Few studies in Asian populations have analyzed how glucagon secretion is affected by ingested glucose, proteins or lipids, individually. To investigate the…”
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ATP6AP2 is robustly expressed in pancreatic β cells and neuroendocrine tumors, and plays a role in maintaining cellular viability by Taguchi, Tomomi, Kimura, Kaori, Suzuki, Agena, Fujishima, Rei, Shimizu, Naoya, Hoshiyama, Ayako, Masaki, Tsuguto, Inoue, Mitsuko, Kato, Yukiko, Satomi, Takebe, Takano, Koji, Imada, Tasuku, Sasaki, Shugo, Miyatsuka, Takeshi

“…ATP6AP2, also known as (pro)renin receptor, has been shown to be expressed in several tissues including pancreatic β cells. Whereas ATP6AP2 plays an important…”
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STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1 by Wakabayashi, Yuka, Miyatsuka, Takeshi, Miura, Masaki, Himuro, Miwa, Taguchi, Tomomi, Iida, Hitoshi, Nishida, Yuya, Fujitani, Yoshio, Watada, Hirotaka

“…As diabetes results from the absolute or relative deficiency of insulin secretion from pancreatic β cells, possible methods to efficiently generate surrogate β…”
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Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model by Fukunaka, Ayako, Shimura, Mari, Ichinose, Takayuki, Pereye, Ofejiro B., Nakagawa, Yuko, Tamura, Yasuko, Mizutani, Wakana, Inoue, Ryota, Inoue, Takato, Tanaka, Yuto, Sato, Takashi, Saitoh, Tatsuya, Fukada, Toshiyuki, Nishida, Yuya, Miyatsuka, Takeshi, Shirakawa, Jun, Watada, Hirotaka, Matsuyama, Satoshi, Fujitani, Yoshio

“…Metal homeostasis is tightly regulated in cells and organisms, and its disturbance is frequently observed in some diseases such as neurodegenerative diseases…”
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Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production by Takahashi, Masaya, Miyatsuka, Takeshi, Suzuki, Luka, Osonoi, Sho, Himuro, Miwa, Miura, Masaki, Katahira, Takehiro, Wakabayashi, Yuka, Fukunaka, Ayako, Nishida, Yuya, Fujitani, Yoshio, Takeda, Satoru, Mizukami, Hiroki, Itakura, Atsuo, Watada, Hirotaka

“…Pancreatic β-cell mass is known to be considerably altered during pregnancy and after parturition in rodents and humans. While β-cell mass increases during…”
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Defective autophagy in vascular smooth muscle cells enhances atherosclerotic plaque instability by Masuyama, Atsushi, Mita, Tomoya, Azuma, Kosuke, Osonoi, Yusuke, Nakajima, Kenichi, Goto, Hiromasa, Nishida, Yuya, Miyatsuka, Takeshi, Mitsumata, Masako, Watada, Hirotaka

“…Autophagy is considered as an evolutionarily conserved cellular catabolic process. Defective autophagy has been implicated in various human diseases, including…”
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Gαᵢ/ₒ-coupled receptor signaling restricts pancreatic β-cell expansion by Berger, Miles, Scheel, David W., Macias, Hector, Miyatsuka, Takeshi, Kim, Hail, Hoang, Phuong, Ku, Greg M., Honig, Gerard, Liou, Angela, Tang, Yunshuo, Regard, Jean B., Sharifnia, Panid, Yu, Lisa, Wang, Juehu, Coughlin, Shaun R., Conklin, Bruce R., Deneris, Evan S., Tecott, Laurence H., German, Michael S.

“…Significance This paper shows that a class of receptors known to modulate insulin release by pancreatic β cells also regulates the proliferation of these cells…”
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Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas9 by Yazawa, Rieko, Nishida, Yuya, Aoyama, Shuhei, Tanida, Isei, Miyatsuka, Takeshi, Suzuki, Luka, Himuro, Miwa, Haruna, Hidenori, Takubo, Noriyuki, Shimizu, Toshiaki, Watada, Hirotaka

“…Autophagy is a mechanism of bulk protein degradation that plays an important role in regulating homeostasis in many organisms. Among several methods for…”
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