Search Results - "MIYAMOTO, Yohei"

Update on the pharmacokinetics and redox properties of protein-bound uremic toxins by Watanabe, Hiroshi, Miyamoto, Yohei, Otagiri, Masaki, Maruyama, Toru

“…Protein-bound uremic toxins, such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, p-cresyl sulfate, hippuric acid, and indoleacetic…”
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Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia Treatment by Kadowaki, Daisuke, Sakaguchi, Shoichi, Miyamoto, Yohei, Taguchi, Kazuaki, Muraya, Nanako, Narita, Yuki, Sato, Keizo, Chuang, Victor Tuan Giam, Maruyama, Toru, Otagiri, Masaki, Hirata, Sumio

“…Uric acid exerts an important antioxidant effect against external oxidative stress under physiological conditions. However, uric acid itself can increase…”
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Pharmacological effects of a vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, on cisplatin-induced fibrosis in rats by UCHIDA, Masashi, MIYOSHI, Tomoya, MIYAMOTO, Yohei

“…Cisplatin (CDDP) is a chemotherapeutic agent that is widely used in the treatment of lymphomas and solid malignancies. However, its clinical usage is limited…”
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A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy by Kodama, Azusa, Watanabe, Hiroshi, Tanaka, Ryota, Tanaka, Hisae, Chuang, Victor T G, Miyamoto, Yohei, Wu, Qiong, Endo, Masayuki, Hamasaki, Keisuke, Ishima, Yu, Fukagawa, Masafumi, Otagiri, Masaki, Maruyama, Toru

“…Contrast-induced nephropathy (CIN), caused by a combination of the direct tubular toxicity of contrast media, a reduction in medullary blood flow, and the…”
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Urinary cystatin C as a biomarker for acute kidney injury and its immunohistochemical localization in kidney in the CDDP-treated rats by Togashi, Yuko, Sakaguchi, Yuka, Miyamoto, Mari, Miyamoto, Yohei

“…Cystatin C, a cysteine protease inhibitor, is a novel biomarker of renal damage. In the present study, we examined the urinary and plasma levels of cystatin C…”
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Toxicological effect of emodin in mouse testicular gene expression profile by Oshida, Keiyu, Hirakata, Mikito, Maeda, Akihisa, Miyoshi, Tomoya, Miyamoto, Yohei

“…ABSTRACT Emodin (1,3,8‐trihydroxy‐6‐methyl‐anthraquinone) is a herbal medicine extracted from the rhizomes of Rheum palmatum, and is known as an inhibitor of…”
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Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats by Maruyama, Toru, Otagiri, Masaki, Hirata, Sumio, Chuang, Victor Tuan Giam, Miyamoto, Yohei, Narita, Yuki, Uchimura, Kohei, Kitamura, Kenichiro, Miyamura, Shigeyuki, Kadowaki, Daisuke, Muraya, Nanako, Taguchi, Kazuaki

“…Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular…”
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Nalfurafine hydrochloride, a selective κ opioid receptor agonist, has no reinforcing effect on intravenous self-administration in rhesus monkeys by Nakao, Kaoru, Hirakata, Mikito, Miyamoto, Yohei, Kainoh, Mie, Wakasa, Yoshio, Yanagita, Tomoji

“…Nalfurafine hydrochloride [(E)-N-[17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6β-yl]-3-(furan-3-yl)-N-methylprop-2-enamide monohydrochloride;…”
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A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate by Miyamoto, Yohei, Iwao, Yasunori, Mera, Katsumi, Watanabe, Hiroshi, Kadowaki, Daisuke, Ishima, Yu, Chuang, Victor Tuan Giam, Sato, Keizo, Otagiri, Masaki, Maruyama, Toru

“…A uremic toxin, CMPF induces cell damage through a generation of its radical intermediate in renal proximal tubular cell…”
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Identification of Transporters Involved in Beraprost Sodium Transport In Vitro by Oshida, Keiyu, Shimamura, Masahiro, Seya, Kazuhiro, Ando, Akihiro, Miyamoto, Yohei

“…Background and Objective Beraprost sodium (BPS) is a chemically stable and orally active prostacyclin analog that is used in the treatment of chronic arterial…”
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Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig by Higashi, Eriko, Ando, Akihiro, Iwano, Shunsuke, Murayama, Norie, Yamazaki, Hiroshi, Miyamoto, Yohei

“…ABSTRACT The microminipig, a small minipig, was bred as a novel experimental animal for nonclinical pharmacology/toxicology studies by Fuji Micra Inc…”
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Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice by Asaoka, Yoshiji, Togashi, Yuko, Mutsuga, Mayu, Imura, Naoko, Miyoshi, Tomoya, Miyamoto, Yohei

“…Chemical-induced hepatocellular hypertrophy is frequently observed in rodents, and is mostly caused by the induction of phase I and phase II drug metabolic…”
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Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats by Togashi, Yuko, Imura, Naoko, Miyamoto, Yohei

“…The usefulness of urinary cystatin C for the early detection of renal damage in anti-glomerular basement membrane (GBM) glomerulonephritis rats was…”
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The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions by Miyamoto, Yohei, Iwao, Yasunori, Tasaki, Yuka, Sato, Keizo, Ishima, Yu, Watanabe, Hiroshi, Kadowaki, Daisuke, Maruyama, Toru, Otagiri, Masaki

“…The effect of the uremic solute indoxyl sulfate (IS) on scavenging superoxide anion radicals (O2-) generated from both the xanthine/xanthine oxidase (X/XO)…”
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p‐Cresyl sulfate, a uremic toxin, causes vascular endothelial and smooth muscle cell damages by inducing oxidative stress by Watanabe, Hiroshi, Miyamoto, Yohei, Enoki, Yuki, Ishima, Yu, Kadowaki, Daisuke, Kotani, Shunsuke, Nakajima, Makoto, Tanaka, Motoko, Matsushita, Kazutaka, Mori, Yoshitaka, Kakuta, Takatoshi, Fukagawa, Masafumi, Otagiri, Masaki, Maruyama, Toru

“…The major cause of death in patients with chronic kidney disease (CKD) is cardiovascular disease. Here, p‐Cresyl sulfate (PCS), a uremic toxin, is considered…”
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The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats by Shi, Junfeng, Liu, Ning, Xiao, Ying, Takei, Yoshinori, Yasue, Misato, Suzuki, Yamato, Hou, Zengye, Ohno, Hiroaki, Yamada, Masateru, Fuchi, Nobuhiro, Oshida, Keiyu, Miyamoto, Yohei, Tsujimoto, Gozoh, Hirasawa, Akira

“…Protein kinase CK2 (“casein kinase II”) is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle…”
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A Novel Vitamin K1 2,3-Epoxide Reductase (VKOR) Inhibitor, 3-Acetyl-5-Methyltetronic Acid, Reduces Experimental Glomerulonephritis by UCHIDA, Masashi, SAKAGUCHI, Yuka, MIYAMOTO, Yohei

“…Excessive proliferation of mesangial cells is observed in various types of glomerular disease including glomerulonephritis (GN), which is progressive in nature…”
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Immunohistochemistry of LAMP-2 and adipophilin for phospholipidosis in liver and kidney in ketoconazole-treated mice by Asaoka, Yoshiji, Togashi, Yuko, Imura, Naoko, Sai, Takafumi, Miyoshi, Tomoya, Miyamoto, Yohei

“…Drug-induced phospholipidosis is an abnormal accumulation of phospholipids in the lysosomes following repeated administration of cationic amphiphilic drugs…”
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Discrimination of genotoxic and non-genotoxic hepatocarcinogens by statistical analysis based on gene expression profiling in the mouse liver as determined by quantitative real-time PCR by Watanabe, Takashi, Suzuki, Takayoshi, Natsume, Masakatsu, Nakajima, Madoka, Narumi, Kazunori, Hamada, Shuichi, Sakuma, Tomohiro, Koeda, Akiko, Oshida, Keiyu, Miyamoto, Yohei, Maeda, Akihisa, Hirayama, Michiasa, Sanada, Hisakazu, Honda, Hiroshi, Ohyama, Wakako, Okada, Emiko, Fujiishi, Yohei, Sutou, Shizuyo, Tadakuma, Ayami, Ishikawa, Yasuyoshi, Kido, Mahoko, Minamiguchi, Rina, Hanahara, Izumi, Furihata, Chie

“…► We quantified gene expression in mouse liver by quantitative real-time PCR. ► We quantified 35 genes selected from our previous DNA microarray studies. ► We…”
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New Insight Into the Redox Properties of Uremic Solute Indoxyl Sulfate as a Pro- and Anti-Oxidant by Miyamoto, Yohei, Watanabe, Hiroshi, Otagiri, Masaki, Maruyama, Toru

“…Indoxyl sulfate, an extensively investigated uremic toxin, is involved in the progression of chronic kidney disease (CKD). Recent clinical data indicate that…”
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