Hypertriglyceridemia is an Independent Risk Factor for Development of Impaired Fasting Glucose and Diabetes Mellitus: a 9-year Longitudinal Study in Japanese

Hypertriglyceridemia is an Independent Risk Factor for Development of Impaired Fasting Glucose and Diabetes Mellitus: a 9-year Longitudinal Study in Japanese

Objective Hypertriglyceridemia is often associated with impaired fasting glucose (IFG) and diabetes mellitus. But the contribution of hypertriglyceridemia to the development of IFG and diabetes mellitus remains unclear. We evaluated whether or not hypertriglyceridemia is a risk factor for the develo...

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Bibliographic Details
Published in:Internal Medicine Vol. 41; no. 7; pp. 516 - 521
Main Authors: KAMETANI, Tomio, KOSHIDA, Hideo, NAGAOKA, Tadasu, MIYAKOSHI, Hisatugu
Format: Journal Article
Language:English
Published: Tokyo The Japanese Society of Internal Medicine 2002
Japanese Society of Internal Medicine
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Blood Glucose - metabolism
Diabetes Complications
Diabetes Mellitus - epidemiology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glucose - metabolism
Humans
hypertension
Hypertension - complications
Hypertension - epidemiology
Hypertriglyceridemia - complications
Hypertriglyceridemia - epidemiology
Incidence
Japan
Longitudinal Studies
Male
Medical sciences
Middle Aged
Obesity
Proportional Hazards Models
Prospective Studies
Risk Factors
Japan
Endocrinopathy
Human
Hypertension
Obesity
Diabetes mellitus
Nutrition disorder
Cardiovascular disease
Metabolic diseases
Lipids
Hyperlipoproteinemia
Enzymopathy
Epidemiology
Japanese
Hyperglycemia
Follow up study
Hypertriglyceridemia
Risk factor
Dyslipemia
Fast
Nutritional status
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Summary:Objective Hypertriglyceridemia is often associated with impaired fasting glucose (IFG) and diabetes mellitus. But the contribution of hypertriglyceridemia to the development of IFG and diabetes mellitus remains unclear. We evaluated whether or not hypertriglyceridemia is a risk factor for the development of IFG and diabetes mellitus. Methods From 1990 through 1999, 7, 222 Japanese with normoglycemia at baseline were followed. Fasting plasma glucose levels were measured. IFG and diabetes mellitus were defined by ADA criteria. Result The multivariate-adjusted relative risks for the development of IFG were 1.38 for hypertriglyceridemia (p=0.001), 1.30 for obesity (p=0.003), 1.29 for hypertension (p=0.007), 1.26 for family history of diabetes (p=0.027), and 1.02 for age (p=0.035). The multivariate-adjusted relative risks for the development of diabetes mellitus were 1.003 for triglyceride level (p=0.013), 1.30 for level of body mass index (p=0.003), and 2.38 for family history of diabetes (p=0.001). Conclusion Hypertriglyceridemia is an independent risk factor for the development of IFG and diabetes mellitus in Japanese patients. (Internal Medicine 41: 516-521, 2002)
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.41.516