Search Results - "MIYAGAWA, Kiyoshi"

Targeting DNA damage response in cancer therapy by Hosoya, Noriko, Miyagawa, Kiyoshi

“…Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing DNA damage. DNA damage is normally recognized and repaired by the…”
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Synaptonemal complex proteins modulate the level of genome integrity in cancers by Hosoya, Noriko, Miyagawa, Kiyoshi

“…The synaptonemal complex (SC) is a proteinaceous structure that is transiently formed during meiosis to promote homologous recombination between maternal and…”
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Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair by Yasuhara, Takaaki, Kato, Reona, Hagiwara, Yoshihiko, Shiotani, Bunsyo, Yamauchi, Motohiro, Nakada, Shinichiro, Shibata, Atsushi, Miyagawa, Kiyoshi

“…Given that genomic DNA exerts its function by being transcribed, it is critical for the maintenance of homeostasis that DNA damage, such as double-strand…”
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Practical Education Program in Precision Cancer Medicine by Miyagawa, Kiyoshi

“…To train medical staffs capable of practicing precision cancer medicine, The University of Tokyo and 5 universities in the Kanto area planned the education…”
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DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells by Sato, Hiro, Niimi, Atsuko, Yasuhara, Takaaki, Permata, Tiara Bunga Mayang, Hagiwara, Yoshihiko, Isono, Mayu, Nuryadi, Endang, Sekine, Ryota, Oike, Takahiro, Kakoti, Sangeeta, Yoshimoto, Yuya, Held, Kathryn D., Suzuki, Yoshiyuki, Kono, Koji, Miyagawa, Kiyoshi, Nakano, Takashi, Shibata, Atsushi

“…Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation in cancer. A DNA double-strand break (DSB) is the most critical type…”
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Implications of the germline variants of DNA damage response genes detected by cancer precision medicine for radiological risk communication and cancer therapy decisions by Hosoya, Noriko, Miyagawa, Kiyoshi

“…Large-scale cancer-associated gene testing is now being rapidly incorporated into clinical settings, and is leading to incidental identification of the…”
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Clinical relevance of the homologous recombination machinery in cancer therapy by Miyagawa, Kiyoshi

“…Cancer chemotherapy and radiotherapy kill cancer cells by inducing DNA damage, unless the lesions are repaired by intrinsic repair pathways. DNA double‐strand…”
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Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model by Fukasawa, Takemichi, Yoshizaki, Ayumi, Ebata, Satoshi, Yoshizaki-Ogawa, Asako, Asano, Yoshihide, Enomoto, Atsushi, Miyagawa, Kiyoshi, Kazoe, Yutaka, Mawatari, Kazuma, Kitamori, Takehiko, Sato, Shinichi

“…Despite antigen affinity of B cells varying from cell to cell, functional analyses of antigen-reactive B cells on individual B cells are missing due to…”
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Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein by Hashimoto, Takuma, Horikawa, Daiki D., Saito, Yuki, Kuwahara, Hirokazu, Kozuka-Hata, Hiroko, Shin-I, Tadasu, Minakuchi, Yohei, Ohishi, Kazuko, Motoyama, Ayuko, Aizu, Tomoyuki, Enomoto, Atsushi, Kondo, Koyuki, Tanaka, Sae, Hara, Yuichiro, Koshikawa, Shigeyuki, Sagara, Hiroshi, Miura, Toru, Yokobori, Shin-ichi, Miyagawa, Kiyoshi, Suzuki, Yutaka, Kubo, Takeo, Oyama, Masaaki, Kohara, Yuji, Fujiyama, Asao, Arakawa, Kazuharu, Katayama, Toshiaki, Toyoda, Atsushi, Kunieda, Takekazu

“…Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade species tolerate almost complete dehydration and exhibit extraordinary…”
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Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens by Kohsaka, Shinji, Tatsuno, Kenji, Ueno, Toshihide, Nagano, Masaaki, Shinozaki‐Ushiku, Aya, Ushiku, Tetsuo, Takai, Daiya, Ikegami, Masachika, Kobayashi, Hiroshi, Kage, Hidenori, Ando, Mizuo, Hata, Keisuke, Ueda, Hiroki, Yamamoto, Shogo, Kojima, Shinya, Oseto, Kumiko, Akaike, Keisuke, Suehara, Yoshiyuki, Hayashi, Takuo, Saito, Tsuyoshi, Takahashi, Fumiyuki, Takahashi, Kazuhisa, Takamochi, Kazuya, Suzuki, Kenji, Nagayama, Satoshi, Oda, Yoshinao, Mimori, Koshi, Ishihara, Soichiro, Yatomi, Yutaka, Nagase, Takahide, Nakajima, Jun, Tanaka, Sakae, Fukayama, Masashi, Oda, Katsutoshi, Nangaku, Masaomi, Miyazono, Kohei, Miyagawa, Kiyoshi, Aburatani, Hiroyuki, Mano, Hiroyuki

“…Tumor molecular profiling is becoming a standard of care for patients with cancer, but the optimal platform for cancer sequencing remains undetermined. We…”
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Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases by Fukasawa, Takemichi, Yoshizaki-Ogawa, Asako, Enomoto, Atsushi, Miyagawa, Kiyoshi, Sato, Shinichi, Yoshizaki, Ayumi

“…Palmoplantar pustulosis (PPP) is a disease that causes recurrent blisters and aseptic pustules on the palms and soles. It has been suggested that both innate…”
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Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors by Fukasawa, Takemichi, Yoshizaki-Ogawa, Asako, Enomoto, Atsushi, Miyagawa, Kiyoshi, Sato, Shinichi, Yoshizaki, Ayumi

“…Itching can decrease quality of life and exacerbate skin symptoms due to scratching. Itching not only contributes to disease progression but also triggers…”
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Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing by Kage, Hidenori, Kohsaka, Shinji, Shinozaki‐Ushiku, Aya, Hiraishi, Yoshihisa, Sato, Jiro, Nagayama, Kazuhiro, Ushiku, Tetsuo, Takai, Daiya, Nakajima, Jun, Miyagawa, Kiyoshi, Aburatani, Hiroyuki, Mano, Hiroyuki, Nagase, Takahide

“…Next‐generation sequencing (NGS) has been implemented in clinical oncology to analyze multiple genes and to guide therapy. In patients with advanced lung…”
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Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia by Enomoto, Atsushi, Fukasawa, Takemichi, Terunuma, Hiroshi, Nakagawa, Keiichi, Yoshizaki, Ayumi, Sato, Shinichi, Miyagawa, Kiyoshi

“…Hyperthermia is a promising anticancer treatment modality. However, the molecular mechanism underlying the thermal sensitivity of tumor cells is largely…”
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Utility of nailfold capillary assessment for predicting psoriatic arthritis based on a prospective observational cohort study by Fukasawa, Takemichi, Toyama, Satoshi, Enomoto, Atsushi, Yoshizaki-Ogawa, Asako, Norimatsu, Yuta, Tateishi, Shoko, Kanda, Hiroko, Miyagawa, Kiyoshi, Sato, Shinichi, Yoshizaki, Ayumi

“…Abstract Objectives PsA is one of the most serious comorbidities associated with psoriasis. While the early intervention in PsA is demanded, risk factors of…”
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SYCP3 regulates strand invasion activities of RAD51 and DMC1 by Kobayashi, Wataru, Hosoya, Noriko, Machida, Shinichi, Miyagawa, Kiyoshi, Kurumizaka, Hitoshi

“…The synaptonemal complex is a higher‐ordered proteinaceous architecture formed between homologous chromosomes. SYCP3 is a major component of the lateral/axial…”
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RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair by Yasuhara, Takaaki, Kato, Reona, Yamauchi, Motohiro, Uchihara, Yuki, Zou, Lee, Miyagawa, Kiyoshi, Shibata, Atsushi

“…Single-stranded DNA (ssDNA) arising as an intermediate of cellular processes on DNA is a potential vulnerability of the genome unless it is appropriately…”
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Ataxia Telangiectasia Mutated (ATM)-mediated DNA Damage Response in Oxidative Stress-induced Vascular Endothelial Cell Senescence[S] by Zhan, Hong, Suzuki, Toru, Aizawa, Kenichi, Miyagawa, Kiyoshi, Nagai, Ryozo

“…Oxidative stress regulates dysfunction and senescence of vascular endothelial cells. The DNA damage response and its main signaling pathway involving ataxia…”
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Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks by Ozaki, Kie, Kato, Reona, Yasuhara, Takaaki, Uchihara, Yuki, Hirakawa, Miyako, Abe, Yu, Shibata, Hiroki, Kawabata-Iwakawa, Reika, Shakayeva, Aizhan, Kot, Palina, Miyagawa, Kiyoshi, Suzuki, Keiji, Matsuda, Naoki, Shibata, Atsushi, Yamauchi, Motohiro

“…Although previous studies have reported that pre-mRNA splicing factors (SFs) are involved in the repair of DNA double-strand breaks (DSBs) via homologous…”
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Serine–Threonine Kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint by Fukasawa, Takemichi, Enomoto, Atsushi, Miyagawa, Kiyoshi

“…Cells respond to DNA damage by activating protein kinase-mediated signaling pathways that promote cell-cycle arrest, DNA repair, or apoptosis. A key regulator…”
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