Search Results - "MITCHESON, J. S"

Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits by Cockerill, S. L., Tobin, A. B., Torrecilla, I., Willars, G. B., Standen, N. B., Mitcheson, J. S.

“…The human ether-a-go-go related gene (hERG) potassium channel is expressed in a variety of tissues including the heart, neurons and some cancer cells. hERG…”
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A Structural Basis for Drug-Induced Long QT Syndrome by Mitcheson, John S., Chen, Jun, Lin, Monica, Culberson, Chris, Sanguinetti, Michael C.

“…Mutations in the HERG K+channel gene cause inherited long QT syndrome (LQT), a disorder of cardiac repolarization that predisposes affected individuals to…”
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Direct block of human ether-a-go-go-related gene potassium channels by caffeine by Cockerill, S L, Mitcheson, J S

“…The human ether-a-go-go-related gene (hERG) potassium channel is expressed in a variety of cell types, including neurons, tumor cells, and cardiac myocytes. In…”
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The S4-S5 Linker Couples Voltage Sensing and Activation of Pacemaker Channels by Chen, Jun, Mitcheson, John S., Tristani-Firouzi, Martin, Lin, Monica, Sanguinetti, Michael C.

“…Voltage-gated channels are normally opened by depolarization and closed by repolarization of the membrane. Despite sharing significant sequence homology with…”
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Cultured adult cardiac myocytes : Future applications, culture methods, morphological and electrophysiological properties by MITCHESON, J. S, HANCOX, J. C, LEVI, A. J

“…Isolated adult cardiac myocytes maintained in primary culture have been used as a model of the adult myocardium for 20 years. With the recent advances and…”
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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate by Mitcheson, J S, Chen, J, Sanguinetti, M C

“…Deactivation of voltage-gated potassium (K(+)) channels can slow or prevent the recovery from block by charged organic compounds, a phenomenon attributed to…”
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Functional Roles of Charged Residues in the Putative Voltage Sensor of the HCN2 Pacemaker Channel by Chen, Jun, Mitcheson, John S., Lin, Monica, Sanguinetti, Michael C.

“…Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to pacemaking activity in specialized neurons and cardiac myocytes. HCN channels…”
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An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes by Mitcheson, J S, Hancox, J C

“…The aim of this study was to measure and compare the profile of rapid delayed rectifier potassium current (IKr) elicited by action potential (AP) waveforms…”
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Combined hERG channel inhibition and disruption of trafficking in drug‐induced long QT syndrome by fluoxetine: a case‐study in cardiac safety pharmacology by Hancox, J C, Mitcheson, J S

“…Drug‐induced prolongation of the rate‐corrected QT interval (QTCI) on the electrocardiogram occurs as an unwanted effect of diverse clinical and…”
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Biophysical properties and molecular basis of cardiac rapid and slow delayed rectifier potassium channels by Mitcheson, J S, Sanguinetti, M C

“…Normal cardiac action potential repolarization is dependent on activation of several K(+) currents, including I(Kr) and I(Ks). I(Kr) activates rapidly at…”
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Predicting drug–hERG channel interactions that cause acquired long QT syndrome by Sanguinetti, Michael C., Mitcheson, John S.

“…Avoiding drug-induced cardiac arrhythmia is recognized as a major hurdle in the successful development of new drugs. The most common problem is acquired long…”
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An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes by Mitcheson, J. S., Hancox, J. C.

“…The aim of this study was to measure and compare the profile of rapid delayed rectifier potassium current (I ^sub Kr^) elicited by action potential (AP)…”
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The effect of internal sodium and caesium on phasic contraction of patch-clamped rabbit ventricular myocytes by Levi, A J, Mitcheson, J S, Hancox, J C

“…1. The voltage dependence of phasic contraction was assessed in rabbit ventricular myocytes. Phasic contraction at all potentials was abolished by exposure to…”
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Modulation by mexiletine of action potentials, L-type Ca current and delayed rectifier K current recorded from isolated rabbit atrioventricular nodal myocytes by Mitcheson, J S, Hancox, J C

“…Using whole-cell patch clamp recordings at 37 degrees C, we have examined the effects of externally applied mexiletine (a class 1b antiarrhythmic agent) on…”
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Inhibition of L‐type calcium current by propafenone in single myocytes isolated from the rabbit atrioventricular node by Hancox, Jules C, Mitcheson, John S

“…The atrioventricular node (AVN) is an important part of the conduction system in the heart and is a significant site of antiarrhythmic drug action. The class 1…”
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Open channel block of HERG K(+) channels by vesnarinone by Kamiya, K, Mitcheson, J S, Yasui, K, Kodama, I, Sanguinetti, M C

“…Vesnarinone, a cardiotonic agent, blocks I(Kr) and, unlike other I(Kr) blockers, produces a frequency-dependent prolongation of action potential duration…”
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Molecular biology of K(+) channels and their role in cardiac arrhythmias by Tristani-Firouzi, M, Chen, J, Mitcheson, J S, Sanguinetti, M C

“…The configuration of cardiac action potentials varies considerably from one region of the heart to another. These differences are caused by differential…”
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Comparison of Na(+)/Ca(2+) exchanger current and of its response to isoproterenol between acutely isolated and short-term cultured adult ventricular myocytes by Pabbathi, V K, Zhang, Y H, Mitcheson, J S, Hinde, A K, Perchenet, L, Arberry, L A, Levi, A J, Hancox, J C

“…The Na(+)/Ca(2+) exchanger protein is present in the cell membrane of many tissue types and plays key roles in Ca(2+) homeostasis, excitation-contraction…”
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Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture by Mitcheson, J S, Hancox, J C, Levi, A J

“…Adult rabbit ventricular myocytes were cultured in a basic medium (Medium 199) for up to 6 days to assess preservation of morphology and ion channel currents…”
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Characteristics of a transient outward current (sensitive to 4-aminopyridine) in Ca2+-tolerant myocytes isolated from the rabbit atrioventricular node by Mitcheson, J S, Hancox, J C

“…A transient outward current (Ito) has been observed in the atrioventricular node (AVN), but its characteristics in Ca-tolerant AVN myocytes have not been…”
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