Search Results - "MITCHELL, THOMAS"

State-Level Data on Suicide Mortality During COVID-19 Quarantine: Early Evidence of a Disproportionate Impact on Racial Minorities by Mitchell, Thomas O., Li, Luming

“…•The age-adjusted rate of completed suicides decreased 13% in Connecticut during the period of strict stay-at-home COVID-19 quarantine.•The proportion of…”
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Revisiting the 1959 Hebgen Lake Earthquake Using Optical Image Correlation; New Constraints on Near‐Field 3D Ground Displacement by Andreuttiova, Lucia, Hollingsworth, James, Vermeesch, Pieter, Mitchell, Thomas M., Bergman, Eric

“…Near‐field surface displacement measurements allow us to quantify the on‐ and off‐fault proportion of earthquake‐related deformation. The Hebgen Lake…”
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Mechanisms generating cancer genome complexity from a single cell division error by Umbreit, Neil T, Zhang, Cheng-Zhong, Lynch, Luke D, Blaine, Logan J, Cheng, Anna M, Tourdot, Richard, Sun, Lili, Almubarak, Hannah F, Judge, Kim, Mitchell, Thomas J, Spektor, Alexander, Pellman, David

“…The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. Signatures of BFB cycles can…”
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The Challenging but Essential Pursuit of Suicide Prevention: Reflections From a Trainee by Mitchell, Thomas O

“…Perhaps the central question Mitchell has been wrestling with is whether most people who commit suicide actually seek help and disclose their suicidal…”
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Timing the initiation of multiple myeloma by Rustad, Even H., Yellapantula, Venkata, Leongamornlert, Daniel, Bolli, Niccolò, Ledergor, Guy, Nadeu, Ferran, Angelopoulos, Nicos, Dawson, Kevin J., Mitchell, Thomas J., Osborne, Robert J., Ziccheddu, Bachisio, Carniti, Cristiana, Montefusco, Vittorio, Corradini, Paolo, Anderson, Kenneth C., Moreau, Philippe, Papaemmanuil, Elli, Alexandrov, Ludmil B., Puente, Xose S., Campo, Elias, Siebert, Reiner, Avet-Loiseau, Herve, Landgren, Ola, Munshi, Nikhil, Campbell, Peter J., Maura, Francesco

“…The evolution and progression of multiple myeloma and its precursors over time is poorly understood. Here, we investigate the landscape and timing of…”
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Microstructural Controls on Thermal Crack Damage and the Presence of a Temperature‐Memory Effect During Cyclic Thermal Stressing of Rocks by Daoud, Ali, Browning, John, Meredith, Philip G., Mitchell, Thomas M.

“…We present results from a series of thermal stressing experiments that used three igneous rocks of different composition, grain size, and origin and…”
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The mutational landscape of normal human endometrial epithelium by Moore, Luiza, Leongamornlert, Daniel, Coorens, Tim H. H., Sanders, Mathijs A., Ellis, Peter, Dentro, Stefan C., Dawson, Kevin J., Butler, Tim, Rahbari, Raheleh, Mitchell, Thomas J., Maura, Francesco, Nangalia, Jyoti, Tarpey, Patrick S., Brunner, Simon F., Lee-Six, Henry, Hooks, Yvette, Moody, Sarah, Mahbubani, Krishnaa T., Jimenez-Linan, Mercedes, Brosens, Jan J., Iacobuzio-Donahue, Christine A., Martincorena, Inigo, Saeb-Parsy, Kourosh, Campbell, Peter J., Stratton, Michael R.

“…All normal somatic cells are thought to acquire mutations, but understanding of the rates, patterns, causes and consequences of somatic mutations in normal…”
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Assessing the Efficiency of Thermal Pressurization Using Natural Pseudotachylyte‐Bearing Rocks by Brantut, Nicolas, Mitchell, Thomas M.

“…The efficiency of thermal pressurization as a dynamic weakening mechanism relies on the thermal and hydraulic properties of the rocks forming the fault core…”
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Genetic architecture and adaptation of flowering time among environments by Yan, Wenjie, Wang, Baosheng, Chan, Emily, Mitchell‐Olds, Thomas

“…Summary The genetic basis of flowering time changes across environments, and pleiotropy may limit adaptive evolution of populations in response to local…”
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Mesoscopic Damage and Fracturing of Heterogeneous Brittle Rocks Based on Three-dimensional Polycrystalline Discrete Element Method by Xu, Tao, Fu, Teng-Fei, Heap, Michael J., Meredith, Philip G., Mitchell, Thomas M., Baud, Patrick

“…Rock heterogeneities often control microcracking on the grain scale and therefore the mechanical behavior of the rock on the macroscale. We therefore studied…”
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A GRIM fate for human neutrophils in airway disease by Mitchell, Thomas C.

“…A neutrophil culture method recapitulates their phenotypic plasticity and may accelerate development of drugs that target pathological subsets in airway…”
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Rupture Energetics in Crustal Rock From Laboratory‐Scale Seismic Tomography by Aben, Franciscus M., Brantut, Nicolas, Mitchell, Thomas M., David, Emmanuel C.

“…The energy released during earthquake rupture is partly radiated as seismic waves and mostly dissipated by frictional heating on the fault interface and by…”
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Mesoscopic time-dependent behavior of rocks based on three-dimensional discrete element grain-based model by Fu, Teng-Fei, Xu, Tao, Heap, Michael J., Meredith, Philip G., Mitchell, Thomas M.

“…A three-dimensional discrete element grain-based stress corrosion model incorporating the theories of subcritical crack growth and chemical reaction rate was…”
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Fault Reactivation by Fluid Injection: Controls From Stress State and Injection Rate by Passelègue, François. X., Brantut, Nicolas, Mitchell, Thomas M.

“…We studied the influence of stress state and fluid injection rate on the reactivation of faults. We conducted experiments on a saw cut Westerly granite sample…”
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Plasticity of plant defense and its evolutionary implications in wild populations of Boechera stricta by Wagner, Maggie R., Mitchell-Olds, Thomas

“…Phenotypic plasticity is thought to impact evolutionary trajectories by shifting trait values in a direction that is either favored by natural selection…”
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Genomic landscape and chronological reconstruction of driver events in multiple myeloma by Maura, Francesco, Bolli, Niccoló, Angelopoulos, Nicos, Dawson, Kevin J., Leongamornlert, Daniel, Martincorena, Inigo, Mitchell, Thomas J., Fullam, Anthony, Gonzalez, Santiago, Szalat, Raphael, Abascal, Federico, Rodriguez-Martin, Bernardo, Samur, Mehmet Kemal, Glodzik, Dominik, Roncador, Marco, Fulciniti, Mariateresa, Tai, Yu Tzu, Minvielle, Stephane, Magrangeas, Florence, Moreau, Philippe, Corradini, Paolo, Anderson, Kenneth C., Tubio, Jose M. C., Wedge, David C., Gerstung, Moritz, Avet-Loiseau, Hervé, Munshi, Nikhil, Campbell, Peter J.

“…The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver…”
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Intra-tumour diversification in colorectal cancer at the single-cell level by Roerink, Sophie F., Sasaki, Nobuo, Lee-Six, Henry, Young, Matthew D., Alexandrov, Ludmil B., Behjati, Sam, Mitchell, Thomas J., Grossmann, Sebastian, Lightfoot, Howard, Egan, David A., Pronk, Apollo, Smakman, Niels, van Gorp, Joost, Anderson, Elizabeth, Gamble, Stephen J., Alder, Chris, van de Wetering, Marc, Campbell, Peter J., Stratton, Michael R., Clevers, Hans

“…Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences…”
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No pain no gain? Adjuvant effects of alum and monophosphoryl lipid A in pertussis and HPV vaccines by Mitchell, Thomas C, Casella, Carolyn R

“…•Vaccine reactogenicity can be misperceived as a greater risk than infectious disease.•Public acceptance of side effects is reduced when infectious risks are…”
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Clonal dynamics of haematopoiesis across the human lifespan by Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas, Dawson, Kevin J., Mende, Nicole, Calderbank, Emily F., Jung, Hyunchul, Mitchell, Thomas, Coorens, Tim H. H., Spencer, David H., Machado, Heather, Lee-Six, Henry, Davies, Megan, Hayler, Daniel, Fabre, Margarete A., Mahbubani, Krishnaa, Abascal, Federico, Cagan, Alex, Vassiliou, George S., Baxter, Joanna, Martincorena, Inigo, Stratton, Michael R., Kent, David G., Chatterjee, Krishna, Parsy, Kourosh Saeb, Green, Anthony R., Nangalia, Jyoti, Laurenti, Elisa, Campbell, Peter J.

“…Age-related change in human haematopoiesis causes reduced regenerative capacity 1 , cytopenias 2 , immune dysfunction 3 and increased risk of blood cancer 4 –…”
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Antagonistic selection and pleiotropy constrain the evolution of plant chemical defenses by Keith, Rose A., Mitchell-Olds, Thomas

“…When pleiotropy is present, genetic correlations may constrain the evolution of ecologically important traits. We used a quantitative genetics approach to…”
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