Search Results - "MITCHELL, R"

Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems by O'Connell, Mitchell R.

“…Prokaryotic adaptive immune systems use Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins for RNA-guided…”
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Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection by East-Seletsky, Alexandra, O’Connell, Mitchell R., Knight, Spencer C., Burstein, David, Cate, Jamie H. D., Tjian, Robert, Doudna, Jennifer A.

“…The CRISPR-associated bacterial enzyme C2c2 is shown to contain two separable, distinct sites for the highly sensitive detection and cleavage of…”
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Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis by McGill, Mitchell R., Jaeschke, Hartmut

“…ABSTRACT Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and…”
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The past and present of serum aminotransferases and the future of liver injury biomarkers by McGill, Mitchell R

“…Laboratory testing is important in the diagnosis and monitoring of liver injury and disease. Current liver tests include plasma markers of injury (e.g…”
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RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes by East-Seletsky, Alexandra, O’Connell, Mitchell R., Burstein, David, Knott, Gavin J., Doudna, Jennifer A.

“…CRISPR adaptive immunity pathways protect prokaryotic cells against foreign nucleic acids using CRISPR RNA (crRNA)-guided nucleases. In type VI-A CRISPR-Cas…”
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Long-read human genome sequencing and its applications by Logsdon, Glennis A., Vollger, Mitchell R., Eichler, Evan E.

“…Over the past decade, long-read, single-molecule DNA sequencing technologies have emerged as powerful players in genomics. With the ability to generate reads…”
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Programmable RNA Tracking in Live Cells with CRISPR/Cas9 by Nelles, David A., Fang, Mark Y., O’Connell, Mitchell R., Xu, Jia L., Markmiller, Sebastian J., Doudna, Jennifer A., Yeo, Gene W.

“…RNA-programmed genome editing using CRISPR/Cas9 from Streptococcus pyogenes has enabled rapid and accessible alteration of specific genomic loci in many…”
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The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans by McGill, Mitchell R

“…Our understanding of the fundamental molecular mechanisms of acetaminophen (APAP) hepatotoxicity began in 1973 to 1974, when investigators at the US National…”
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Filaggrin Loss-of Function Mutations are Associated With Persistence of Egg and Milk Allergy by Lester, Mitchell R.

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Atopic Dermatitis and Risk of Autoimmunity Conditions: Population-based Cohort Study by Lester, Mitchell R.

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Comparative Efficacy of Mepolizumab, Benralizumab, and Dupilumab in Eosinophilic Asthma: A Bayesian Network Meta-analysis by Lester, Mitchell R.

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity by Jaeschke, Hartmut, McGill, Mitchell R., Ramachandran, Anup

“…Hepatotoxicity is a serious problem during drug development and for the use of many established drugs. For example, acetaminophen overdose is currently the…”
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Role of Prefrontal Persistent Activity in Working Memory by Riley, Mitchell R, Constantinidis, Christos

“…The prefrontal cortex is activated during working memory, as evidenced by fMRI results in human studies and neurophysiological recordings in animal models…”
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Programmable RNA recognition and cleavage by CRISPR/Cas9 by O’Connell, Mitchell R., Oakes, Benjamin L., Sternberg, Samuel H., East-Seletsky, Alexandra, Kaplan, Matias, Doudna, Jennifer A.

“…In the presence of a short DNA oligonucleotide containing a protospacer adjacent motif, a guide-RNA-programmed Cas9 is able to specifically bind and/or cleave…”
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Animal models of drug-induced liver injury by McGill, Mitchell R., Jaeschke, Hartmut

“…Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and regulators. It is the most common cause of acute liver failure in…”
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Antibody Responses to the SARS-CoV-2 Vaccine in Individuals With Inborn Errors of Immunity by Lester, Mitchell R.

“…PURPOSE OF THE STUDY: To evaluate the impact of genetic diagnosis and treatment on antibody response to coronavirus disease 2019 (COVID-19) vaccine and related…”
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Efficacy of Medical Treatments for Vernal Keratoconjunctivitis: A Systematic Review and Meta-analysis by Lester, Mitchell R.

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Use of Multiple Epinephrine Doses in Anaphylaxis: A Systematic Review and Meta-analysis by Lester, Mitchell R.

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HiCanu: accurate assembly of segmental duplications, satellites, and allelic variants from high-fidelity long reads by Nurk, Sergey, Walenz, Brian P, Rhie, Arang, Vollger, Mitchell R, Logsdon, Glennis A, Grothe, Robert, Miga, Karen H, Eichler, Evan E, Phillippy, Adam M, Koren, Sergey

“…Complete and accurate genome assemblies form the basis of most downstream genomic analyses and are of critical importance. Recent genome assembly projects have…”
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RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a by Tambe, Akshay, East-Seletsky, Alexandra, Knott, Gavin J., Doudna, Jennifer A., O’Connell, Mitchell R.

“…CRISPR-Cas13a enzymes are RNA-guided, RNA-activated RNases. Their properties have been exploited as powerful tools for RNA detection, RNA imaging, and RNA…”
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