Search Results - "MITCHELL, Daniel A"

Dendritic Cell Lectin-Targeting Sentinel-like Unimolecular Glycoconjugates To Release an Anti-HIV Drug by Zhang, Qiang, Su, Lu, Collins, Jennifer, Chen, Guosong, Wallis, Russell, Mitchell, Daniel A, Haddleton, David M, Becer, C. Remzi

“…A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and…”
Get full text

Tinker, tailor, soldier, cell: the role of C-type lectins in the defense and promotion of disease by Arnold, James N, Mitchell, Daniel A

“…C-type lectins (CTLs) represent a large family of soluble and membrane-bound proteins which bind calcium dependently via carbohydrate recognition domains…”
Get full text

Dissecting the Molecular Mechanism of IVIg Therapy: The Interaction between Serum IgG and DC-SIGN is Independent of Antibody Glycoform or Fc Domain by Yu, Xiaojie, Vasiljevic, Snezana, Mitchell, Daniel A., Crispin, Max, Scanlan, Christopher N.

“…Intravenous immunoglobulin (IVIg) therapy is used to treat a wide range of autoimmune conditions and consists of pooled immunoglobulin G (IgG) from healthy…”
Get full text

Structure of the C1r–C1s interaction of the C1 complex of complement activation by Almitairi, Jamal O. M., Girija, Umakhanth Venkatraman, Furze, Christopher M., Simpson-Gray, Xanthe, Badakshi, Farah, Marshall, Jamie E., Schwaeble, Wilhelm J., Mitchell, Daniel A., Moody, Peter C. E., Wallis, Russell

“…The multiprotein complex C1 initiates the classical pathway of complement activation on binding to antibody–antigen complexes, pathogen surfaces, apoptotic…”
Get full text

Site-Directed Conjugation of “Clicked” Glycopolymers To Form Glycoprotein Mimics:  Binding to Mammalian Lectin and Induction of Immunological Function by Geng, Jin, Mantovani, Giuseppe, Tao, Lei, Nicolas, Julien, Chen, Gaojian, Wallis, Russell, Mitchell, Daniel A, Johnson, Benjamin R. G, Evans, Stephen D, Haddleton, David M

“…Synthesis of well-defined neoglycopolymer−protein biohybrid materials and a preliminary study focused on their ability of binding mammalian lectins and…”
Get full text

Specific and Differential Binding of N‑Acetylgalactosamine Glycopolymers to the Human Macrophage Galactose Lectin and Asialoglycoprotein Receptor by Tanaka, Joji, Gleinich, Anne S, Zhang, Qiang, Whitfield, Richard, Kempe, Kristian, Haddleton, David M, Davis, Thomas P, Perrier, Sébastien, Mitchell, Daniel A, Wilson, Paul

“…A range of glycopolymers composed of N-acetylgalactosamine were prepared via sequential Cu­(I)-mediated polymerization and alkyne–azide click (CuAAC). The…”
Get full text

A Chemical Genomics Approach to Drug Reprofiling in Oncology: Antipsychotic Drug Risperidone as a Potential Adenocarcinoma Treatment by Dilly, Suzanne J, Clark, Andrew J, Marsh, Andrew, Mitchell, Daniel A, Cain, Ricky, Fishwick, Colin W.G, Taylor, Paul C

“…Abstract Drug reprofiling is emerging as an effective paradigm for discovery of cancer treatments. Herein, an antipsychotic drug is immobilised using the Magic…”
Get full text

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation by Girija, Umakhanth Venkatraman, Gingras, Alexandre R., Marshall, Jamie E., Panchal, Roshni, Sheikh, Md. Arif, Gál, Péter, Schwaeble, Wilhelm J., Mitchell, Daniel A., Moody, Peter C. E., Wallis, Russell

“…Complement component C1, the complex that initiates the classical pathway of complement activation, is a 790-kDa assembly formed from the target-recognition…”
Get full text

Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function by Singh, Sonali, Almuhanna, Yasir, Alshahrani, Mohammad Y., Lowman, Douglas W., Rice, Peter J., Gell, Chris, Ma, Zuchao, Graves, Bridget, Jackson, Darryl, Lee, Kelly, Juarez, Rucha, Koranteng, Janice, Muntaka, Sirina, Daniel A. Mitchell, da Silva, Ana C., Hussain, Farah, Yilmaz, Gokhan, Mastrotto, Francesca, Irie, Yasuhiko, Williams, Paul, Williams, David L., Cámara, Miguel, Martinez-Pomares, Luisa

“…Bacterial biofilms represent a challenge to the healthcare system because of their resilience against antimicrobials and immune attack. Biofilms consist of…”
Get full text

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR by Drickamer, Kurt, Guo, Yuan, Feinberg, Hadar, Conroy, Edward, Mitchell, Daniel A, Alvarez, Richard, Blixt, Ola, Taylor, Maureen E, Weis, William I

“…Both the dendritic cell receptor DC-SIGN and the closely related endothelial cell receptor DC-SIGNR bind human immunodeficiency virus and enhance infection…”
Get full text

Glycerol-Free Cryopreservation of Red Blood Cells Enabled by Ice-Recrystallization-Inhibiting Polymers by Deller, Robert C, Vatish, Manu, Mitchell, Daniel A, Gibson, Matthew I

“…Cryopreservation is fundamental in prolonging the viabilities of cells and tissues of clinical and biotechnological relevance ex vivo. Furthermore, there is an…”
Get full text

Paths reunited: Initiation of the classical and lectin pathways of complement activation by Wallis, Russell, Mitchell, Daniel A, Schmid, Ralf, Schwaeble, Wilhelm J, Keeble, Anthony H

“…Abstract Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been…”
Get full text

Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR by Feinberg, Hadar, Mitchell, Daniel A., Drickamer, Kurt, Weis, William I.

“…Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells,…”
Get full text

Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors by Jiang, Yan, Kelly, Richard, Peters, Amy, Fulka, Helena, Dickinson, Adam, Mitchell, Daniel A, St John, Justin C

“…Interspecies somatic cell nuclear transfer (iSCNT) involves the transfer of a nucleus or cell from one species into the cytoplasm of an enucleated oocyte from…”
Get full text

Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome by Venkatraman Girija, Umakhanth, Furze, Christopher M, Gingras, Alexandre R, Yoshizaki, Takayuki, Ohtani, Katsuki, Marshall, Jamie E, Wallis, A Katrine, Schwaeble, Wilhelm J, El-Mezgueldi, Mohammed, Mitchell, Daniel A, Moody, Peter C E, Wakamiya, Nobutaka, Wallis, Russell

“…Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to…”
Get full text

Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation by Gingras, Alexandre R., Girija, Umakhanth Venkatraman, Keeble, Anthony H., Panchal, Roshni, Mitchell, Daniel A., Moody, Peter C.E., Wallis, Russell

“…Complement activation contributes directly to health and disease. It neutralizes pathogens and stimulates immune processes. Defects lead to immunodeficiency…”
Get full text

Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications by Czajkowsky, Daniel M., Andersen, Jan Terje, Fuchs, Anja, Wilson, Timothy J., Mekhaiel, David, Colonna, Marco, He, Jianfeng, Shao, Zhifeng, Mitchell, Daniel A., Wu, Gang, Dell, Anne, Haslam, Stuart, Lloyd, Katy A., Moore, Shona C., Sandlie, Inger, Blundell, Patricia A., Pleass, Richard J.

“…The remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD)…”
Get full text

Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells by Madsen, Jens, Gaiha, Gaurav D, Palaniyar, Nades, Dong, Tao, Mitchell, Daniel A, Clark, Howard W

“…Surfactant Protein D (SP-D) is an oligomerized C-type lectin molecule with immunomodulatory properties and involvement in lung surfactant homeostasis in the…”
Get full text

Extended Neck Regions Stabilize Tetramers of the Receptors DC-SIGN and DC-SIGNR by Feinberg, Hadar, Guo, Yuan, Mitchell, Daniel A., Drickamer, Kurt, Weis, William I.

“…The human cell surface receptors DC-SIGN (dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin) and DC-SIGNR (DC-SIGN-related) bind to…”
Get full text

Protein-Protein Interaction between Surfactant Protein D and DC-SIGN via C-Type Lectin Domain Can Suppress HIV-1 Transfer by Dodagatta-Marri, Eswari, Mitchell, Daniel A, Pandit, Hrishikesh, Sonawani, Archana, Murugaiah, Valarmathy, Idicula-Thomas, Susan, Nal, Béatrice, Al-Mozaini, Maha M, Kaur, Anuvinder, Madan, Taruna, Kishore, Uday

“…Surfactant protein D (SP-D) is a soluble C-type lectin, belonging to the collectin (collagen-containing calcium-dependent lectin) family, which acts as an…”
Get full text