Search Results - "MITCH, W. E"

Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues by Dong, J, Dong, Y, Dong, Y, Chen, F, Mitch, W E, Zhang, L

“…Background/Objective: In mice, a high-fat diet (HFD) induces obesity, insulin resistance and myostatin production. We tested whether inhibition of myostatin in…”
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Regulation of epithelial sodium channels by the ubiquitin-proteasome proteolytic pathway by Malik, B, Price, S R, Mitch, W E, Yue, Q, Eaton, D C

“…Amiloride-sensitive epithelial Na+ channels (ENaC) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. The magnitude of…”
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Role of Nedd4-2 and polyubiquitination in epithelial sodium channel degradation in untransfected renal A6 cells expressing endogenous ENaC subunits by Malik, B, Yue, Q, Yue, G, Chen, X J, Price, S R, Mitch, W E, Eaton, D C

“…Amiloride-sensitive epithelial sodium channels (ENaC) are responsible for transepithelial Na(+) transport in the kidney, lung, and colon. The channel consists…”
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Effects of high doses of glucocorticoids on free amino acids, ribosomes and protein turnover in human muscle by Löfberg, E., Gutierrez, A., Wernerman, J., Anderstam, B., Mitch, W. E., Price, S. R., Bergström, J., Alvestrand, A.

“…Background  Treatment with glucocorticosteroids causes a negative nitrogen balance, but the kinetic mechanisms responsible for this catabolic effect are…”
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Molecular mechanisms activating muscle protein degradation in chronic kidney disease and other catabolic conditions by Du, J., Hu, Z., Mitch, W. E.

“…Muscle atrophy is a prominent feature of chronic kidney disease (CKD) and is frequent in other catabolic conditions. Results from animal models of these…”
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Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states by Lecker, S H, Solomon, V, Mitch, W E, Goldberg, A L

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Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes by MITCH, W. E, MEDINA, R, GRIEBER, S, MAY, R. C, ENGLAND, B. K, PRICE, S. R, BAILEY, J. L, GOLDBERG, A. L

“…Metabolic acidosis often leads to loss of body protein due mainly to accelerated protein breakdown in muscle. To identify which proteolytic pathway is…”
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The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway by Bailey, J L, Wang, X, England, B K, Price, S R, Ding, X, Mitch, W E

“…Chronic renal failure (CRF) is associated with negative nitrogen balance and loss of lean body mass. To identify specific proteolytic pathways activated by…”
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AHA dietary guidelines : Revision 2000 : A statement for healthcare professionals from the Nutrition Committee of the American Heart Association by KRAUSS, Ronald M, ECKEL, Robert H, LICHTENSTEIN, Alice H, MITCH, William E, MULLIS, Rebecca, ROBINSON, Killian, WYLIE-ROSETT, Judith, ST. JEOR, Sachiko, SUTTIE, John, TRIBBLE, Diane L, BAZZARRE, Terry L, HOWARD, Barbara, APPEL, Lawrence J, DANIELS, Stephen R, DECKELBAUM, Richard J, ERDMAN, John W, KRIS-ETHERTON, Penny, GOLDBERG, Ira J, KOTCHEN, Theodore A

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Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats by Lecker, S. H., Solomon, V., Price, S. R., Kwon, Y. T., Mitch, W. E., Goldberg, A. L.

“…Insulin deficiency (e.g., in acute diabetes or fasting) is associated with enhanced protein breakdown in skeletal muscle leading to muscle wasting. Because…”
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Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle by Price, S R, England, B K, Bailey, J L, Van Vreede, K, Mitch, W E

“…In rat muscle metabolic acidosis increases ATP-dependent protein degradation and levels of mRNAs for ubiquitin (Ub) and proteasome subunits. Because…”
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Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription by Price, S R, Bailey, J L, Wang, X, Jurkovitz, C, England, B K, Ding, X, Phillips, L S, Mitch, W E

“…In normal subjects and diabetic patients, insulin suppresses whole body proteolysis suggesting that the loss of lean body mass and muscle wasting in…”
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Catabolism in uremia : The impact of metabolic acidosis by FRANCH, H. A, MITCH, W. E

“…Chronic metabolic acidosis stimulates the catabolism of bone and muscle in experimental animals and humans. The toxicity caused by acidosis involves changes in…”
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Factors causing malnutrition in patients with chronic uremia by Mitch, William E., Maroni, Bradley J.

“…There is abundant evidence that patients with chronic renal failure (CRF), including those treated by hemodialysis or peritoneal dialysis, have evidence of…”
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Should protein intake be restricted in predialysis patients? by Walser, Mackenzie, Mitch, William E., Maroni, Bradley J., Kopple, Joel D.

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Mechanisms of defects in muscle protein metabolism in rats with chronic uremia: influence of metabolic acidosis by MAY, R. C, KELLY, R. A, MITCH, W. E, KARAPANOS, G

“…Chronic renal failure (CRF) is associated with metabolic acidosis and abnormal muscle protein metabolism. As we have shown that acidosis by itself stimulates…”
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Early detection and the course of glomerular injury in patients with sickle cell anemia by Guasch, Antonio, Cua, Millicent, Mitch, William E.

“…Early detection and the course of glomerular injury in patients with sickle cell anemia. We performed a cross sectional analysis of glomerular function in 34…”
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A method for estimating nitrogen intake of patients with chronic renal failure by Maroni, Bradley J., Steinman, Theodore I., Mitch, William E.

“…A method for estimating nitrogen intake of patients with chronic renal failure. A method for monitoring dietary compliance would be useful in treating patients…”
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Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy by Brenner, Barry M, Cooper, Mark E, de Zeeuw, Dick, Keane, William F, Mitch, William E, Parving, Hans-Henrik, Remuzzi, Giuseppe, Snapinn, Steven M, Zhang, Zhonxin, Shahinfar, Shahnaz

“…Angiotensin-receptor blockade may delay the onset of end-stage renal disease and ameliorate heart failure in patients with type 2 diabetes. Interruption of the…”
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Glucocorticoids and acidosis stimulate protein and amino acid catabolism in vivo by May, Robert C., Bailey, James L., Mitch, William E., Masud, Tahsin, England, Brian K.

“…Glucocorticoids and acidosis stimulate protein and amino acid catabolism in vivo. We have shown that chronic metabolic acidosis in awake rats accelerates whole…”
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