Search Results - "MISSINEO, Antonino"

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening by Turcano, Lorenzo, Torrente, Esther, Missineo, Antonino, Andreini, Matteo, Gramiccia, Marina, Di Muccio, Trentina, Genovese, Ilaria, Fiorillo, Annarita, Harper, Steven, Bresciani, Alberto, Colotti, Gianni, Ilari, Andrea

“…Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite…”
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Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme by Turcano, Lorenzo, Battista, Theo, De Haro, Esther Torrente, Missineo, Antonino, Alli, Cristina, Paonessa, Gicomo, Colotti, Gianni, Harper, Steven, Fiorillo, Annarita, Ilari, Andrea, Bresciani, Alberto

“…Trypanothione reductase (TR) is a key enzyme that catalyzes the reduction of trypanothione, an antioxidant dithiol that protects Trypanosomatid parasites from…”
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High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting by Ullman, Christopher, Mathonet, Pascale, Oleksy, Arkadiusz, Diamandakis, Agata, Tomei, Licia, Demartis, Anna, Nardi, Chiara, Sambucini, Sonia, Missineo, Antonino, Alt, Karen, Hagemeyer, Christoph E, Harris, Matt, Hedt, Amos, Weis, Roland, Gehlsen, Kurt R

“…Abdurins are a novel antibody-like scaffold derived from the engineering of a single isolated CH2 domain of human IgG. Previous studies established the…”
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Molecular Characterization of the Multiple Interactions of SpsD, a Surface Protein from Staphylococcus pseudintermedius, with Host Extracellular Matrix Proteins by Pietrocola, Giampiero, Geoghegan, Joan A, Rindi, Simonetta, Di Poto, Antonella, Missineo, Antonino, Consalvi, Valerio, Foster, Timothy J, Speziale, Pietro

“…Staphylococcus pseudintermedius, a commensal and pathogen of dogs and occasionally of humans, expresses surface proteins potentially involved in host…”
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NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model by Moretti, Daniele, Tambone, Sara, Cerretani, Mauro, Fezzardi, Paola, Missineo, Antonino, Sherman, Leticia-Toledo, Munoz-Sajuan, Ignacio, Harper, Steven, Dominquez, Celia, Pacifici, Robert, Tomei, Licia, Park, Larry, Bresciani, Alberto

“…Oxidative stress has been associated with pathogenesis in several diseases including Huntington's disease (HD), a neurodegenerative disorder caused by a…”
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Oligomerization, albumin binding and catabolism of therapeutic peptides in the subcutaneous compartment: An investigation on lipidated GLP-1 analogs by Gallo, Mariana, Vanni, Domitilla, Esposito, Simone, Alaimo, Nadine, Orvieto, Federica, Rulli, Federica, Missineo, Antonino, Caretti, Fulvia, Bonelli, Fabio, Veneziano, Maria, Orsatti, Laura, Monteagudo, Edith

“…•Aggregation, albumin binding and catabolism play a key role in peptides SC absorption.•GLP-1 analogs were used as tool peptides to study the interplay between…”
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Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1) by Bresciani, Alberto, Missineo, Antonino, Gallo, Mariana, Cerretani, Mauro, Fezzardi, Paola, Tomei, Licia, Cicero, Daniel Oscar, Altamura, Sergio, Santoprete, Alessia, Ingenito, Raffaele, Bianchi, Elisabetta, Pacifici, Robert, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Harper, Steven, Toledo-Sherman, Leticia, Park, Larry C.

“…Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress at the site of action, hold much therapeutic potential in…”
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Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction by Colarusso, Stefania, De Simone, Daniele, Frattarelli, Tommaso, Andreini, Matteo, Cerretani, Mauro, Missineo, Antonino, Moretti, Daniele, Tambone, Sara, Kempf, Georg, Augustin, Martin, Steinbacher, Stefan, Munoz-Sanjuan, Ignacio, Park, Larry, Summa, Vincenzo, Tomei, Licia, Bresciani, Alberto, Dominguez, Celia, Toledo-Sherman, Leticia, Bianchi, Elisabetta

“…[Display omitted] Inhibition of KEAP1-NRF2 protein-protein interaction is considered a promising strategy to selectively and effectively activate NRF2, a…”
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SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease by Colarusso, Stefania, Ferrigno, Federica, Ponzi, Simona, Pavone, Francesca, Conte, Immacolata, Abate, Luigi, Beghetto, Elisa, Missineo, Antonino, Amaudrut, Jerome, Bresciani, Alberto, Paonessa, Giacomo, Tomei, Licia, Montalbetti, Christian, Bianchi, Elisabetta, Toniatti, Carlo, Ontoria, Jesus M.

“…[Display omitted] Zika virus (ZIKV) is a member of the Flaviviridae family that can cause neurological disorders and congenital malformations. The NS2B-NS3…”
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Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors by Torrente, Esther, Fodale, Valentina, Ciammaichella, Alina, Ferrigno, Federica, Ontoria, Jesus M., Ponzi, Simona, Rossetti, Ilaria, Sferrazza, Alessio, Amaudrut, Jérôme, Missineo, Antonino, Esposito, Simone, Palombo, Simone, Nibbio, Martina, Cerretani, Mauro, Bisbocci, Monica, Cellucci, Antonella, di Marco, Annalise, Alli, Cristina, Pucci, Vincenzo, Toniatti, Carlo, Petrocchi, Alessia

“…Protein tyrosine phosphatase SHP2 is an oncogenic protein that can regulate different cytokine receptor and receptor tyrosine kinase signaling pathways. We…”
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IsdC from Staphylococcus lugdunensis induces biofilm formation under low-iron growth conditions by Missineo, Antonino, Di Poto, Antonella, Geoghegan, Joan A, Rindi, Simonetta, Heilbronner, Simon, Gianotti, Valentina, Arciola, Carla Renata, Foster, Timothy J, Speziale, Pietro, Pietrocola, Giampiero

“…Staphylococcus lugdunensis is a coagulase-negative staphylococcus that is a commensal of humans and an opportunistic pathogen. It can cause a spectrum of…”
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Abstract 2610: Discovery of AM E3: A novel α-TLSPR monoclonal antibody for the ADC treatment of CRLF2-rearranged Ph-like B-ALL by Dall'Armi, Claudia, Biasio, Valentina Di, Paolini, Chantal, Natale, Daniela, Scalabrì, Francesco, Missineo, Antonino, Alaimo, Nadine, Nuzzo, Maurizio, Demartis, Anna, Pasquale, Pamela Di, Benoni, Roberto, Caretti, Fulvia, Beghetto, Elisa, Colaceci, Fabrizio, Sasso, Romina, Pucci, Vincenzo, Carugo, Alessandro, Tomei, Licia, Toniatti, Carlo

“…Background: Patients affected by Ph-like B-cell acute lymphoblastic leukemia (B-ALL) have a high mortality rate and elevated levels of disease relapse upon…”
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Abstract 1975: Discovery of I-1000233, a potent, selective and brain permeable SHP2 allosteric inhibitor by Puca, Francesca, Fabbrini, Danilo, Ciammaichella, Alina, Missineo, Antonino, Bisbocci, Monica, Nibbio, Martina, Marco, Annalise Di, Apicella, Claudia, Colaceci, Fabrizio, Sasso, Romina, Natale, Daniela, Scalabrì, Francesco, Alli, Cristina, Pucci, Vincenzo, Montalbetti, Christian, Petrocchi, Alessia, Carugo, Alessandro, Toniatti, Carlo

“…Background: SHP2 (Src homology region 2-containing protein tyrosine phosphatase 2) is a target of interest for cancer therapy due to its key role in the…”
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Toll-like receptors (TLRs) in innate immune defense against Staphylococcus aureus by PIETROCOLA, Giampiero, ARCIOLA, Carla Renata, RINDI, Simonetta, POTO, Antonella Di, MISSINEO, Antonino, MONTANARO, Lucio, SPEZIALE, Pietro

“…Toll-like receptors (TLRs) are the most important class of innate pattern recognition receptors (PRRs) by which host immune and non-immune cells are able to…”
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A21 Development of an Nrf2-KEAP1 protein-protein disruptor for proof of concept by Bresciani, Alberto, Cerretani, Mauro, D’Amico, Melania, Fezzardi, Paola, Gallo, Mariana, Missineo, Antonino, Moretti, Daniele, Santoprete, Alessia, Tambone, Sara, Tomei, Licia, Dominguez, Celia, Sanjuan, Ignacio Munoz, Sherman, Leticia Toledo, Park, Larry

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Identification by High-Throughput Screening of Pseudomonas Acyl-Coenzyme A Synthetase Inhibitors by Turcano, Lorenzo, Visaggio, Daniela, Frangipani, Emanuela, Missineo, Antonino, Andreini, Matteo, Altamura, Sergio, Visca, Paolo, Bresciani, Alberto

“…Pseudomonas infections are common among hospitalized, immunocompromised, and chronic lung disease patients. These infections are recalcitrant to common…”
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Molecular Characterization of the Multiple Interactions of SpsD, a Surface Protein from Staphylococcus pseudintermedius, with Host Extracellular Matrix Proteins. e66901 by Pietrocola, Giampiero, Geoghegan, Joan A, Rindi, Simonetta, Poto, Antonella Di, Missineo, Antonino, Consalvi, Valerio, Foster, Timothy J, Speziale, Pietro

“…Staphylococcus pseudintermedius, a commensal and pathogen of dogs and occasionally of humans, expresses surface proteins potentially involved in host…”
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