Search Results - "MISNER, Dinah L"

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer by Sampath, Deepak, Zabka, Tanja S, Misner, Dinah L, O'Brien, Thomas, Dragovich, Peter S

“…NAD is a metabolite that is an important cofactor and second messenger for a number of cellular processes such as genomic stability and metabolism that are…”
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Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development by Crawford, James J, Johnson, Adam R, Misner, Dinah L, Belmont, Lisa D, Castanedo, Georgette, Choy, Regina, Coraggio, Melis, Dong, Liming, Eigenbrot, Charles, Erickson, Rebecca, Ghilardi, Nico, Hau, Jonathan, Katewa, Arna, Kohli, Pawan Bir, Lee, Wendy, Lubach, Joseph W, McKenzie, Brent S, Ortwine, Daniel F, Schutt, Leah, Tay, Suzanne, Wei, BinQing, Reif, Karin, Liu, Lichuan, Wong, Harvey, Young, Wendy B

“…Bruton’s tyrosine kinase (Btk) is a nonreceptor cytoplasmic tyrosine kinase involved in B-cell and myeloid cell activation, downstream of B-cell and Fcγ…”
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Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D−/−) mice by Rutten, Kris, Misner, Dinah L., Works, Melissa, Blokland, Arjan, Novak, Thomas J., Santarelli, Luca, Wallace, Tanya L.

“…Elevation of intracellular cyclic adenosine monophosphate (cAMP) concentrations and subsequent regulation of downstream target gene expression through…”
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Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 Neurons by Misner, Dinah L, Sullivan, Jane M

“…Cannabinoids, the active constituents of marijuana, are known to impair learning and memory. Receptors for cannabinoids are highly expressed in the…”
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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH by Vandyck, Koen, McGowan, David C, Luong, Xuan G, Stevens, Sarah K, Jekle, Andreas, Gupta, Kusum, Misner, Dinah L, Chanda, Sushmita, Serebryany, Vladimir, Welch, Michael, Hu, Haiyang, Lv, Zhidan, Williams, Caroline, Maskos, Klaus, Lammens, Alfred, Stoycheva, Antitsa D, Lin, Tse-I, Blatt, Lawrence M, Beigelman, Leonid N, Symons, Julian A, Raboisson, Pierre, Deval, Jerome

“…Agonists of thyroid hormone receptor β (THR-β) decreased LDL cholesterol (LDL-C) and triglyceride (TG) levels in human clinical trials for patients with…”
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Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase by Zabka, Tanja S, Singh, Jatinder, Dhawan, Preeti, Liederer, Bianca M, Oeh, Jason, Kauss, Mara A, Xiao, Yang, Zak, Mark, Lin, Tori, McCray, Bobbi, La, Nghi, Nguyen, Trung, Beyer, Joseph, Farman, Cynthia, Uppal, Hirdesh, Dragovich, Peter S, O'Brien, Thomas, Sampath, Deepak, Misner, Dinah L

“…Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein with intra- and extra-cellular functions as an enzyme, cytokine, growth factor, and…”
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Assessing hERG Channel Inhibition Using PatchXpress by Ly, Justin Q., BS, Shyy, Gordon, BS, Misner, Dinah L., PhD

“…PatchXpress, an automated 16-channel parallel patch clamp system, was used to determine inhibition of human ether-a-go-go related gene (hERG) potassium…”
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Neuregulin1 (NRG1) Signaling through Fyn Modulates NMDA Receptor Phosphorylation: Differential Synaptic Function in NRG1+/- Knock-Outs Compared with Wild-Type Mice by Bjarnadottir, Maria, Misner, Dinah L, Haverfield-Gross, Sascha, Bruun, Silas, Helgason, Vignir G, Stefansson, Hreinn, Sigmundsson, Arnar, Firth, David R, Nielsen, Berit, Stefansdottir, Ragnheidur, Novak, Thomas J, Stefansson, Kari, Gurney, Mark E, Andresson, Thorkell

“…We previously identified Neuregulin1 (NRG1) as a gene contributing to the risk of developing schizophrenia. Furthermore, we showed that NRG1+/- mutant mice…”
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Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats by Erickson, Rebecca I, Schutt, Leah K, Tarrant, Jacqueline M, McDowell, Michelle, Liu, Lichuan, Johnson, Adam R, Lewin-Koh, Sock-Cheng, Hedehus, Maj, Ross, Jed, Carano, Richard A D, Staflin, Karin, Zhong, Fiona, Crawford, James J, Zhong, Shelly, Reif, Karin, Katewa, Arna, Wong, Harvey, Young, Wendy B, Dambach, Donna M, Misner, Dinah L

“…Bruton's tyrosine kinase (BTK) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling. Small molecule…”
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Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout ( PDE4B −/−) mice by Rutten, Kris, Wallace, Tanya L., Works, Melissa, Prickaerts, Jos, Blokland, Arjan, Novak, Thomas J., Santarelli, Luca, Misner, Dinah L.

“…3′–5′-Cyclic adenosine monophosphate (cAMP) is known to be an important regulator of synaptic plasticity. The effects of cAMP are mediated through downstream…”
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Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid by Tarrant, Jacqueline M., Dhawan, Preeti, Singh, Jatinder, Zabka, Tanja S., Clarke, Emer, DosSantos, Garry, Dragovich, Peter S., Sampath, Deepak, Lin, Tori, McCray, Bobbi, La, Nghi, Nguyen, Trung, Kauss, Ariel, Dambach, Donna, Misner, Dinah L., Diaz, Dolores, Uppal, Hirdesh

“…Abstract Nicotinamide adenine dinucleotide (NAD) is an essential co-factor in glycolysis and is a key molecule involved in maintaining cellular energy…”
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3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists by ZHAO, Shu-Hai, BERGER, Jacob, CLARK, Robin D, SETHOFER, Steven G, KRAUSS, Nancy E, BROTHERS, Julie M, MARTIN, Renee S, MISNER, Dinah L, SCHWAB, Dietmar, ALEXANDROVA, Ludmila

“…A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT(6) receptor antagonists. Many of the compounds…”
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The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075 by Vendeville, Sandrine, Amblard, Franck, Bassit, Leda, Beigelman, Leonid N, Blatt, Lawrence M, Chen, Xiaoyuan, Chou, Lang, Kum, Dieudonné Buh, Chanda, Sushmita, Deval, Jerome, Geng, Xiu, Gupta, Kusum, Jekle, Andreas, Hu, Haiyang, Hu, Xiaojuan, Kang, Hyunsoon, Liu, Cheng, Liu, Jyanwei, McGowan, David C, Misner, Dinah L, Raboisson, Pierre, Sanchez, Abel Acosta, Serebryany, Vladimir, Stoycheva, Antitsa D, Symons, Julian A, Tan, Hua, Vanrusselt, Hannah, Williams, Caroline, Welch, Michael, Zhang, Liangliang, Zhang, Qingling, Zhang, Yafeng, Schinazi, Raymond F, Smith, David B, Debing, Yannick

“…Chronic hepatitis B (CHB) represents a significant unmet medical need with few options beyond lifelong treatment with nucleoside analogues, which rarely leads…”
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Interactions at the human ether a go‐go (hERG) potassium channel investigated through multiple radioligands by Au, Eugene, Vu, Amanda, Ly, Justin Q, Misner, Dinah L, Kondru, Rama K, Martin, Renee S

“…OBJECTIVE AND METHODS The objective of this study was to explore potentially different modes of binding to the hERG channel through competition binding with…”
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3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT sub(6) receptor antagonists by Zhao, Shu-Hai, Berger, Jacob, Clark, Robin D, Sethofer, Steven G, Krauss, Nancy E, Brothers, Julie M, Martin, Renee S, Misner, Dinah L, Schwab, Dietmar, Alexandrova, Ludmila

“…A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT sub(6) receptor antagonists. Many of the compounds…”
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Neuregulin1 (NRG1) Signaling through Fyn Modulates NMDA Receptor Phosphorylation: Differential Synaptic Function in NRG1 super(+/-) Knock-Outs Compared with Wild-Type Mice by Bjarnadottir, Maria, Misner, Dinah L, Haverfield-Gross, Sascha, Bruun, Silas, Helgason, Vignir G, Stefansson, Hreinn, Sigmundsson, Arnar, Firth, David R, Nielsen, Berit, Stefansdottir, Ragnheidur, Novak, Thomas J, Stefansson, Kari, Gurney, Mark E, Andresson, Thorkell

“…We previously identified Neuregulin1 (NRG1) as a gene contributing to the risk of developing schizophrenia. Furthermore, we showed that NRG1 super(+/-) mutant…”
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3,4-Dihydro-2 H-benzo[1,4]oxazine derivatives as 5-HT 6 receptor antagonists by Zhao, Shu-Hai, Berger, Jacob, Clark, Robin D., Sethofer, Steven G., Krauss, Nancy E., Brothers, Julie M., Martin, Renee S., Misner, Dinah L., Schwab, Dietmar, Alexandrova, Ludmila

“…The synthesis and structure–activity relationships of a series of 3,4-dihydro-2 H-benzo[1,4]oxazine based 5-HT 6 antagonists are described. A series of novel…”
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A cardiovascular safety assessment paradigm for the early identification of proarrhythmic and torsadagenic compounds by Misner, Dinah L., Frantz, C., Meierhenry, E., Fielden, M., Guo, L., Ly, J., Uppal, H., Rotstein, D., Gralinski, M., Senese, P., Albassam, M., Chanda, Sushmita, Platz, Stefan, Kolaja, K.

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Assessing hERG Channel Inhibition Using PatchXpress by Ly, Justin Q., Shyy, Gordon, Misner, Dinah L.

“…PatchXpress, an automated 16-channel parallel patch clamp system, was used to determine inhibition of human ether-a-go-go related gene (hERG) potassium…”
Get full text