Search Results - "MIRZA, Amer M"

ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation by Muthusamy, Baby Periyanayaki, Budi, Erine H, Katsuno, Yoko, Lee, Matthew K, Smith, Susan M, Mirza, Amer M, Akhurst, Rosemary J, Derynck, Rik

“…Epithelial-mesenchymal transition (EMT) is a normal cell differentiation event during development and contributes pathologically to carcinoma and fibrosis…”
Get full text

Intratumoral delivery of TransCon™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction by Zúñiga, Luis Alejandro, Leßmann, Torben, Uppal, Karan, Bisek, Nicola, Hong, Enping, Rasmussen, Caroline E., Karlsson, Jens-Jakob, Zettler, Joachim, Holten-Andersen, Lars, Bang, Kathy, Thakar, Dhruv, Lee, Yu-Chi, Martinez, Salomon, Sabharwal, Simran Singh, Stark, Sebastian, Faltinger, Frank, Kracker, Oliver, Weisbrod, Samuel, Müller, Robin, Voigt, Tobias, Bigott, Kornelia, Tabrizifard, Mohammad, Breinholt, Vibeke Miller, Mirza, Amer M., Rosen, David B., Sprogøe, Kennett, Punnonen, Juha

“…Abstract Background Intratumoral (IT) delivery of toll-like receptor (TLR) agonists has shown encouraging anti-tumor benefit in preclinical and early clinical…”
Get full text

Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT by Mirza, Amer M., Gysin, Stephan, Malek, Nisar, Nakayama, Kei-ichi, Roberts, James M., McMahon, Martin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice by Bhaskar, Vinay, Yin, Johnny, Mirza, Amer M, Phan, Dan, Vanegas, Sandra, Issafras, Hassan, Michelson, Kristen, Hunter, John J, Kantak, Seema S

“…Abstract Objective Atherosclerosis is a condition that is increasingly contributing to worldwide mortality through complications such as stroke and myocardial…”
Get full text

Effects of the RAF MEK ERK and PI3K AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells by SHELTON, John G, STEELMAN, Linda S, MCCUBREY, James A, LEE, John T, KNAPP, Steven L, BLALOCK, William L, MOYE, Phillip W, FRANKLIN, Richard A, POHNERT, Steven C, MIRZA, Amer M, MCMAHON, Martin

“…The Raf/MEK/ERK kinase cascade is pivotal in transmitting signals from membrane receptors to transcription factors that control gene expression culminating in…”
Get full text

Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms by Bedinger, Daniel, Lao, Llewelyn, Khan, Shireen, Lee, Steve, Takeuchi, Toshihiko, Mirza, Amer M

“…Transforming growth factor (TGF)β levels are elevated in, and drive the progression of, numerous disease states such as advanced metastatic cancer and systemic…”
Get full text

XOMA 052, an anti‐IL‐1β monoclonal antibody, prevents IL‐1β‐mediated insulin resistance in 3T3‐L1 adipocytes by Handa, Masahisa, Vanegas, Sandra, Maddux, Betty A., Mendoza, Nerissa, Zhu, Shirley, Goldfine, Ira D., Mirza, Amer M.

“…Objective: Interleukin‐1β (IL‐1β) has recently been implicated as a major cytokine that is involved in the pancreatic islet inflammation of type 2 diabetes…”
Get full text

Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium by Flanders, Kathleen C, Yang, Yu-An, Herrmann, Michelle, Chen, JinQiu, Mendoza, Nerissa, Mirza, Amer M, Wakefield, Lalage M

“…Transforming growth factor-βs (TGF-βs) regulate tissue homeostasis, and their expression is perturbed in many diseases. The three isoforms (TGF-β1, -β2, and…”
Get full text

Kinetic Approach to Pathway Attenuation Using XOMA 052, a Regulatory Therapeutic Antibody That Modulates Interleukin-1β Activity by Roell, Marina K., Issafras, Hassan, Bauer, Robert J., Michelson, Kristen S., Mendoza, Nerissa, Vanegas, Sandra I., Gross, Lisa M., Larsen, Paul D., Bedinger, Daniel H., Bohmann, David J., Nonet, Genevieve H., Liu, Naichi, Lee, Steve R., Handa, Masahisa, Kantak, Seema S., Horwitz, Arnold H., Hunter, John J., Owyang, Alexander M., Mirza, Amer M., Corbin, John A., White, Mark L.

“…Many therapeutic antibodies act as antagonists to competitively block cellular signaling pathways. We describe here an approach for the therapeutic use of…”
Get full text

P215 Filgotinib, a janus kinase 1 selective inhibitor, modulates disease-associated cytokines in patients with active RA by Taylor, Peter C, Elboudwarej, Emon, Li, Wanying, Hawtin, Rachael E, Liu, Jinfeng, Mirza, Amer M

“…Abstract Background Filgotinib (FIL), an oral JAK1-selective inhibitor, was safe and effective in FINCH2, a randomised, double-blind, placebo (PBO)-controlled,…”
Get full text

6821 Characterization Of A Novel Oral Small Molecule PTH1R Agonist: Proof Of Concept For An Alternative To Injectable Peptide-Based Therapy For Hypoparathyroidism by Zhang, Jun, Gomez, Ivan, He, Chen, Wang, Jialu, Du, Xiaohui, Nguyen, Kenny, Alvarez, Kiana, Mirza, Amer M

“…Abstract Disclosure: J. Zhang: None. I. Gomez: None. C. He: None. J. Wang: None. X. Du: None. K. Nguyen: None. K. Alvarez: None. A.M. Mirza: None…”
Get full text

9263 Characterization Of A Novel Oral Small Molecule PTH1R Agonist: Proof Of Concept For An Alternative To Injectable Peptide-Based Therapy For Hypoparathyroidism by Zhang, Jun, Gomez, Ivan, He, Chen, Wang, Jialu, Du, Xiaohui, Nguyen, Kenny, Alvarez, Kiana, Mirza, Amer M

“…Abstract Disclosure: J. Zhang: Employee; Self; Septerna Inc.. I. Gomez: None. C. He: Employee; Self; Septerna Inc. J. Wang: Employee; Self; Septerna Inc. X…”
Get full text

O02 The JAK1-selective inhibitor filgotinib reverses the disease-associated transcriptional profile in the blood of patients with active rheumatoid arthritis by Taylor, Peter, Downie, Bryan, Zhuo, Luting, Gindin, Yevgeniy, Tarrant, Jacqueline, Galien, René, Liu, Jinfeng, Mirza, Amer M

Get full text

Abstract 1768: An anti-TGF-β1/2 antibody that spares TGF-β3 retains full anti-tumor efficacy and generates an improved metabolic profile by Yang, Yu-an, Vasu, Srividya, Yang, Howard, Lee, Maxwell P., Rane, Sushil, Mirza, Amer M., Wakefield, Lalage M.

“…Abstract TGF-β family members are overexpressed in many advanced cancers and correlate with metastasis and poor prognosis. Based on encouraging preclinical…”
Get full text

Abstract LB-306: Impacting Humoral Hypercalcemia of Malignancy (HHM) and associated PTH1R-mediated morbidities: Characterization of an anti-PTH1R antagonist monoclonal antibody to reverse hypercalcemia by Mirza, Amer M., Choppin, Agnes, Bedinger, Daniel, Hunt, Rachel, Cotter, Robyn, Pongo, Elizabeth, Ahluwalia, Kiran, Tran, Catarina, Lao, Llewelyn, Lind, Kristin, Wijesuriya, Sujeewa, Webster, Lynn, Zhang, Fangjiu, Johnson, Kirk, Takeuchi, Toshihiko, Levy, Raphael

“…Abstract Humoral Hypercalcemia of Malignancy (HHM) occurs in 20-30 percent of advanced cancers, both solid tumors and hematologic malignancies, and is the most…”
Get full text

ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-[Beta]-Induced Smad Activation: e1002325 by Muthusamy, Baby Periyanayaki, Budi, Erine H, Katsuno, Yoko, Lee, Matthew K, Smith, Susan M, Mirza, Amer M, Akhurst, Rosemary J, Derynck, Rik

“…Epithelial-mesenchymal transition (EMT) is a normal cell differentiation event during development and contributes pathologically to carcinoma and fibrosis…”
Get full text

XOMA 052, an Anti-IL-1[Beta] Monoclonal Antibody, Prevents IL-1[Beta]-Mediated Insulin Resistance in 3T3-L1 Adipocytes by Handa, Masahisa, Vanegas, Sandra, Maddux, Betty A, Mendoza, Nerissa, Zhu, Shirley, Goldfine, Ira D, Mirza, Amer M

“…Interleukin-1β (IL-1β) has recently been implicated as a major cytokine that is involved in the pancreatic islet inflammation of type 2 diabetes mellitus. This…”
Get full text

HCD122, an Antagonist Human Anti-CD40 Monoclonal Antibody, Inhibits Tumor Growth in Xenograft Models of Human Diffuse Large B-Cell Lymphoma, a Subset of Non-Hodgkins Lymphoma by Hsu, Ssucheng J., Esposito, Lin A., Aukerman, Sharon L., Kantak, Seema, Mirza, Amer M.

“…CD40, a member of the tumor necrosis factor receptor family, is expressed in all human B-cell malignancies and engagement by the CD40 ligand (CD40L) is…”
Get full text

Kinetic Approach to Pathway Attenuation Using XOMA 052, a Regulatory Therapeutic Antibody That Modulates Interleukin-1b Activity by Roell, Marina K, Issafras, Hassan, Bauer, Robert J, Michelson, Kristen S, Mendoza, Nerissa, Vanegas, Sandra I, Gross, Lisa M, Larsen, Paul D, Bedinger, Daniel H, Bohmann, David J, Nonet, Genevieve H, Liu, Naichi, Lee, Steve R, Handa, Masahisa, Kantak, Seema S, Horwitz, Arnold H, Hunter, John J, Owyang, Alexander M, Mirza, Amer M, Corbin, John A, White, Mark L

“…Many therapeutic antibodies act as antagonists to competitively block cellular signaling pathways. We describe here an approach for the therapeutic use of…”
Get full text

Surgical fixation of extra-articular distal humerus fractures with a posterolateral plate through a triceps-reflecting technique by Scolaro, John A., MD, Voleti, Pramod, MD, Makani, Amun, MD, Namdari, Surena, MD, Mirza, Amer, MD, Mehta, Samir, MD

“…Background Surgical management of extra-articular distal humerus fractures results in predictable fracture alignment. Open reduction and internal fixation also…”
Get full text